Cannabis Compound Database: Showing Protein Ubiquitin carboxyl-terminal hydrolase 16 (CDBP04613)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04613

Secondary Accession Numbers

Not Available

Name

Ubiquitin carboxyl-terminal hydrolase 16

Description

Not Available

Synonyms

Deubiquitinating enzyme 16
Ubiquitin thiolesterase 16
Ubiquitin-processing protease UBP-M
Ubiquitin-specific-processing protease 16

Gene Name

USP16

Protein Type

Enzyme

Biological Properties

General Function

Involved in ubiquitin thiolesterase activity

Specific Function

Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B

GO Classification

Function
metal ion binding
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
ubiquitin thiolesterase activity
thiolester hydrolase activity
ion binding
cation binding
Process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
ubiquitin-dependent protein catabolic process

Cellular Location

Nucleus (Probable)

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

21q22.11

SNPs

USP16

Gene Sequence

>2472 bp
ATGGGAAAGAAACGGACAAAGGGAAAAACTGTTCCAATCGATGATTCCTCTGAAACTTTA
GAACCTGTGTGCAGACACATTAGAAAAGGATTGGAACAAGGTAATTTGAAAAAGGCTTTA
GTGAATGTGGAATGGAATATCTGCCAAGACTGTAAGACTGACAATAAAGTGAAAGATAAA
GCTGAAGAAGAAACAGAAGAAAAGCCTTCAGTTTGGCTGTGTCTTAAATGTGGCCATCAG
GGCTGTGGCAGAAATTCTCAGGAGCAGCATGCCTTGAAGCACTATCTGACGCCAAGATCT
GAACCTCACTGTCTGGTTCTTAGTTTGGACAACTGGAGTGTATGGTGTTACGTATGTGAT
AATGAGGTCCAGTATTGTAGTTCAAACCAGTTGGGTCAAGTGGTTGATTATGTCAGAAAA
CAAGCCAGCATTACAACTCCAAAGCCAGCAGAGAAAGATAATGGAAATATTGAACTTGAA
AATAAAAAATTAGAAAAAGAGAGTAAGAATGAACAAGAGAGAGAAAAGAAGGAAAACATG
GCTAAAGAGAATCCTCCCATGAATTCTCCTTGCCAAATAACCGTGAAAGGACTCAGTAAT
TTGGGAAACACATGTTTCTTCAATGCAGTTATGCAGAACTTGTCACAAACACCAGTGCTT
AGAGAACTACTAAAAGAAGTGAAAATGTCTGGAACAATTGTAAAAATTGAACCACCTGAT
TTGGCATTAACAGAACCATTAGAAATAAACCTTGAGCCTCCAGGCCCTCTTACTTTAGCC
ATGAGCCAGTTTCTTAATGAGATGCAAGAGACCAAAAAGGGGGTTGTGACACCGAAAGAA
CTCTTTTCTCAGGTCTGTAAAAAAGCAGTGCGGTTTAAAGGCTATCAGCAGCAAGACAGC
CAGGAGCTGCTTCGCTACTTATTGGATGGGATGAGAGCAGAAGAACACCAAAGAGTGAGT
AAAGGAATACTTAAAGCATTTGGTAATTCTACTGAAAAGTTGGATGAAGAACTAAAAAAT
AAAGTTAAAGATTATGAGAAGAAAAAATCAATGCCAAGTTTTGTTGACCGCATCTTTGGT
GGTGAACTAACTAGTATGATCATGTGTGATCAATGCAGAACTGTCTCCTTGGTTCATGAA
TCTTTCCTTGATTTGTCCCTCCCAGTTTTAGATGATCAGAGTGGTAAGAAAAGTGTAAAT
GATAAAAATCTGAAAAAGACAGTGGAGGATGAAGATCAAGATAGTGAGGAAGAAAAAGAT
AACGACAGTTACATAAAAGAGAGAAGTGATATTCCTTCTGGAACAAGTAAGCACTTACAG
AAAAAAGCAAAGAAACAAGCCAAAAAGCAAGCCAAGAACCAACGAAGACAACAAAAAATT
CAAGGAAAAGTTCTTCATTTAAATGATATTTGTACTATTGACCATCCTGAAGACAGTGAA
TATGAAGCTGAAATGTCACTTCAAGGAGAAGTAAATATTAAATCCAACCATATTTCACAA
GAGGGTGTTATGCATAAAGAATATTGTGTCAACCAGAAAGATTTGAATGGCCAAGCAAAA
ATGATCGAAAGTGTAACTGACAATCAAAAATCCACAGAGGAAGTAGATATGAAAAATATC
AACATGGATAATGATCTGGAGGTTTTAACATCTTCTCCCACTAGGAATTTAAATGGTGCC
TACCTAACGGAAGGGAGCAATGGAGAAGTGGACATTTCCAATGGTTTCAAAAACCTAAAT
TTGAATGCTGCTCTTCATCCTGATGAAATAAATATAGAGATTCTGAATGATAGTCATACT
CCTGGAACAAAGGTGTATGAGGTTGTAAATGAAGATCCAGAAACTGCTTTCTGTACTCTT
GCAAACAGGGAAGTTTTCAATACTGATGAGTGTTCAATCCAACATTGTTTATATCAGTTC
ACCCGTAATGAGAAACTTCGAGATGCGAATAAACTGCTTTGTGAAGTATGCACACGGAGA
CAGTGTAATGGACCAAAGGCAAATATAAAAGGTGAAAGGAAGCATGTTTACACCAATGCC
AAAAAGCAGATGCTAATTTCTCTTGCTCCTCCTGTTCTTACTCTTCATTTAAAGAGATTT
CAGCAGGCTGGTTTTAACCTACGCAAAGTTAACAAACACATAAAGTTTCCGGAAATCTTA
GATTTGGCTCCTTTTTGCACCCTTAAATGTAAGAATGTTGCAGAAGAAAATACAAGGGTA
CTCTATTCCTTATATGGAGTTGTTGAACACAGTGGTACTATGAGGTCGGGGCATTACACT
GCCTATGCCAAGGCAAGAACCGCAAATAGTCATCTCTCTAATCTTGTTCTTCACGGTGAT
ATTCCACAAGATTTTGAAATGGAATCAAAAGGGCAGTGGTTTCACATCAGCGACACACAT
GTGCAAGCTGTGCCTACAACTAAAGTACTAAACTCACAAGCGTACCTCCTATTTTATGAG
AGAATACTGTAA

Protein Properties

Number of Residues

823

Molecular Weight

93569.6

Theoretical pI

6.93

Pfam Domain Function

UCH (PF00443 )
zf-UBP (PF02148 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin carboxyl-terminal hydrolase 16
MGKKRTKGKTVPIDDSSETLEPVCRHIRKGLEQGNLKKALVNVEWNICQDCKTDNKVKDK
AEEETEEKPSVWLCLKCGHQGCGRNSQEQHALKHYLTPRSEPHCLVLSLDNWSVWCYVCD
NEVQYCSSNQLGQVVDYVRKQASITTPKPAEKDNGNIELENKKLEKESKNEQEREKKENM
AKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPD
LALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDS
QELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFG
GELTSMIMCDQCRTVSLVHESFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKD
NDSYIKERSDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSE
YEAEMSLQGEVNIKSNHISQEGVMHKEYCVNQKDLNGQAKMIESVTDNQKSTEEVDMKNI
NMDNDLEVLTSSPTRNLNGAYLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHT
PGTKVYEVVNEDPETAFCTLANREVFNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRR
QCNGPKANIKGERKHVYTNAKKQMLISLAPPVLTLHLKRFQQAGFNLRKVNKHIKFPEIL
DLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTMRSGHYTAYAKARTANSHLSNLVLHGD
IPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFYERIL

External Links

GenBank ID Protein

75992941

UniProtKB/Swiss-Prot ID

Q9Y5T5

UniProtKB/Swiss-Prot Entry Name

UBP16_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001032410.1

GeneCard ID