Identification
HMDB Protein ID CDBP04612
Secondary Accession Numbers Not Available
Name Carboxymethylenebutenolidase homolog
Description Not Available
Synonyms Not Available
Gene Name CMBL
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, in liver and intestine. May also activate beta-lactam antibiotics faropenem medoxomil and lenampicillin.
GO Classification
Cellular Component
cytosol
Function
hydrolase activity
catalytic activity
Molecular Function
hydrolase activity
Cellular Location
  1. Cytoplasm
  2. cytosol
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs CMBL
Gene Sequence
>738 bp
ATGGCTAACGAAGCTTATCCTTGTCCGTGTGACATTGGCCACAGACTTGAGTATGGAGGG
CTAGGCCGTGAAGTTCAAGTCGAGCACATCAAGGCTTATGTCACCAAATCCCCCGTTGAT
GCAGGCAAAGCTGTGATTGTCATTCAAGATATATTTGGCTGGCAGTTGCCCAATACCAGA
TATATAGCTGACATGATCTCAGGAAATGGATACACAACCATTGTTCCAGACTTCTTTGTA
GGGCAAGAGCCTTGGGACCCCTCTGGCGACTGGTCTATCTTCCCTGAGTGGCTGAAAACA
AGAAATGCCCAGAAGATCGATAGAGAGATCAGTGCTATCTTGAAGTATCTGAAACAACAG
TGTCATGCCCAGAAAATTGGCATCGTGGGATTCTGCTGGGGTGGAACTGCTGTCCATCAT
TTGATGATGAAATACTCAGAATTCAGGGCAGGGGTGTCCGTCTATGGCATTGTCAAGGAT
TCTGAAGACATTTACAATTTAAAGAACCCCACTTTGTTCATTTTTGCTGAAAATGATGTT
GTGATTCCACTCAAGGACGTATCTTTGCTGACTCAGAAGTTGAAAGAACACTGCAAAGTT
GAATATCAAATTAAAACATTTTCTGGGCAGACTCATGGGTTCGTGCATCGGAAGAGAGAA
GATTGCTCACCTGCAGACAAGCCCTACATTGACGAGGCCAGAAGGAATTTAATTGAGTGG
CTGAACAAGTACATGTAG
Protein Properties
Number of Residues 245
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Carboxymethylenebutenolidase homolog
MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTR
YIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQ
CHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDV
VIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEW
LNKYM
GenBank ID Protein 27526513
UniProtKB/Swiss-Prot ID Q96DG6
UniProtKB/Swiss-Prot Entry Name CMBL_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ278125
GeneCard ID CMBL
GenAtlas ID CMBL
HGNC ID HGNC:25090
References
General References Not Available