| Identification |
|---|
| HMDB Protein ID
| CDBP04611 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peroxiredoxin-4 |
| Description
| Not Available |
| Synonyms
|
- AOE37-2
- Antioxidant enzyme AOE372
- Peroxiredoxin IV
- Prx-IV
- Thioredoxin peroxidase AO372
- Thioredoxin-dependent peroxide reductase A0372
|
| Gene Name
| PRDX4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in antioxidant activity |
| Specific Function
| Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation.
|
| GO Classification
|
| Biological Process |
| I-kappaB phosphorylation |
| Cellular Component |
| extracellular space |
| mitochondrion |
| Function |
| peroxiredoxin activity |
| catalytic activity |
| antioxidant activity |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| oxidoreductase activity |
| Molecular Function |
| thioredoxin peroxidase activity |
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xp22.11 |
| SNPs
| PRDX4 |
| Gene Sequence
|
>816 bp
ATGGAGGCGCTGCCGCTGCTAGCCGCGACAACTCCGGACCACGGCCGCCACCGAAGGCTG
CTTCTGCTGCCGCTACTGCTGTTCCTGCTGCCGGCTGGAGCTGTGCAGGGCTGGGAGACA
GAGGAGAGGCCCCGGACTCGCGAAGAGGAGTGCCACTTCTACGCGGGTGGACAAGTGTAC
CCGGGAGAGGCATCCCGGGTATCGGTCGCCGACCACTCCCTGCACCTAAGCAAAGCGAAG
ATTTCCAAGCCAGCGCCCTACTGGGAAGGAACAGCTGTGATCGATGGAGAATTTAAGGAG
CTGAAGTTAACTGATTATCGTGGGAAATACTTGGTTTTCTTCTTCTACCCACTTGATTTC
ACATTTGTGTGTCCAACTGAAATTATCGCTTTTGGCGACAGACTTGAAGAATTCAGATCT
ATAAATACTGAAGTGGTAGCATGCTCTGTTGATTCACAGTTTACCCATTTGGCCTGGATT
AATACCCCTCGAAGACAAGGAGGACTTGGGCCAATAAGGATTCCACTTCTTTCAGATTTG
ACCCATCAGATCTCAAAGGACTATGGTGTATACCTAGAGGACTCAGGCCACACTCTTAGA
GGTCTCTTCATTATTGATGACAAAGGAATCCTAAGACAAATTACTCTGAATGATCTTCCT
GTGGGTAGATCAGTGGATGAGACACTACGTTTGGTTCAAGCATTCCAGTACACTGACAAA
CACGGAGAAGTCTGCCCTGCTGGCTGGAAACCTGGTAGTGAAACAATAATCCCAGATCCA
GCTGGAAAGCTGAAGTATTTCGATAAACTGAATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 271 |
| Molecular Weight
| 30539.6 |
| Theoretical pI
| 6.286 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxiredoxin-4
MEALPLLAATTPDHGRHRRLLLLPLLLFLLPAGAVQGWETEERPRTREEECHFYAGGQVY
PGEASRVSVADHSLHLSKAKISKPAPYWEGTAVIDGEFKELKLTDYRGKYLVFFFYPLDF
TFVCPTEIIAFGDRLEEFRSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDL
THQISKDYGVYLEDSGHTLRGLFIIDDKGILRQITLNDLPVGRSVDETLRLVQAFQYTDK
HGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
|
| External Links |
|---|
| GenBank ID Protein
| 13177646 |
| UniProtKB/Swiss-Prot ID
| Q13162 |
| UniProtKB/Swiss-Prot Entry Name
| PRDX4_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC003609 |
| GeneCard ID
| PRDX4 |
| GenAtlas ID
| PRDX4 |
| HGNC ID
| HGNC:17169 |
| References |
|---|
| General References
| Not Available |