Identification
HMDB Protein ID CDBP04607
Secondary Accession Numbers Not Available
Name Receptor-type tyrosine-protein phosphatase-like N
Description Not Available
Synonyms
  1. ICA 512
  2. Islet cell antigen 512
  3. Islet cell autoantigen 3
  4. PTP IA-2
  5. R-PTP-N
Gene Name PTPRN
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Membrane
  2. Single-pass type I membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q35-q36.1
SNPs PTPRN
Gene Sequence
>2940 bp
ATGCGGCGCCCGCGGCGGCCTGGGGGTCTCGGGGGATCCGGGGGTCTCCGGCTGCTCCTC
TGCCTCCTGCTGCTGAGCAGCCGCCCGGGGGGCTGCAGCGCCGTTAGTGCCCACGGCTGT
CTATTTGACCGCAGGCTCTGCTCTCACCTGGAAGTCTGTATTCAGGATGGCTTGTTTGGG
CAGTGCCAGGTGGGAGTGGGGCAGGCCCGGCCCCTTTTGCAAGTCACCTCCCCAGTTCTC
CAACGCTTACAAGGTGTGCTCCGACAACTCATGTCCCAAGGATTGTCCTGGCACGATGAC
CTCACCCAGTATGTGATCTCTCAGGAGATGGAGCGCATCCCCAGGCTTCGCCCCCCAGAG
CCCCGTCCAAGGGACAGGTCTGGCTTGGCACCCAAGAGACCTGGTCCTGCTGGAGAGCTG
CTTTTACAGGACATCCCCACTGGCTCCGCCCCTGCTGCCCAGCATCGGCTTCCACAACCA
CCAGTGGGCAAAGGTGGAGCTGGGGCCAGCTCCTCTCTGTCCCCTCTGCAGGCTGAGCTG
CTCCCGCCTCTCTTGGAGCACCTGCTGCTGCCCCCACAGCCTCCCCACCCTTCACTGAGT
TACGAACCTGCCTTGCTGCAGCCCTACCTGTTCCACCAGTTTGGCTCCCGTGATGGCTCC
AGGGTCTCAGAGGGCTCCCCAGGGATGGTCAGTGTCGGCCCCCTGCCCAAGGCTGAAGCC
CCTGCCCTCTTCAGCAGAACTGCCTCCAAGGGCATATTTGGGGACCACCCTGGCCACTCC
TACGGGGACCTTCCAGGGCCTTCACCTGCCCAGCTTTTTCAAGACTCTGGGCTGCTCTAT
CTGGCCCAGGAGTTGCCAGCACCCAGCAGGGCCAGGGTGCCAAGGCTGCCAGAGCAAGGG
AGCAGCAGCCGGGCAGAGGACTCCCCAGAGGGCTATGAGAAGGAAGGACTAGGGGATCGT
GGAGAGAAGCCTGCTTCCCCAGCTGTGCAGCCAGATGCGGCTCTGCAGAGGCTGGCCGCT
GTGCTGGCGGGCTATGGGGTAGAGCTGCGTCAGCTGACCCCTGAGCAGCTCTCCACACTC
CTGACCCTGCTGCAGCTACTGCCCAAGGGTGCAGGAAGAAATCCGGGAGGGGTTGTAAAT
GTTGGAGCTGATATCAAGAAAACAATGGAGGGGCCGGTGGAGGGCAGAGACACAGCAGAG
CTTCCAGCCCGCACATCCCCCATGCCTGGACACCCCACTGCCAGCCCTACCTCCAGTGAA
GTCCAGCAGGTGCCAAGCCCTGTCTCCTCTGAGCCTCCCAAAGCTGCCAGACCCCCTGTG
ACACCTGTCCTGCTAGAGAAGAAAAGCCCACTGGGCCAGAGCCAGCCCACGGTGGCAGGA
CAGCCCTCAGCCCGCCCAGCAGCAGAGGAATATGGCTACATCGTCACTGATCAGAAGCCC
CTGAGCCTGGCTGCAGGAGTGAAGCTGCTGGAGATCCTGGCTGAGCATGTGCACATGTCC
TCAGGCAGCTTCATCAACATCAGTGTGGTGGGACCAGCCCTCACCTTCCGCATCCGGCAC
AATGAGCAGAACCTGTCTTTGGCTGATGTGACCCAACAAGCAGGGCTGGTGAAGTCTGAA
CTGGAAGCACAGACAGGGCTCCAAATCTTGCAGACAGGAGTGGGACAGAGGGAGGAGGCA
GCTGCAGTCCTTCCCCAAACTGCGCACAGCACCTCACCCATGCGCTCAGTGCTGCTCACT
CTGGTGGCCCTGGCAGGTGTGGCTGGGCTGCTGGTGGCTCTGGCTGTGGCTCTGTGTGTG
CGGCAGCATGCGCGGCAGCAAGACAAGGAGCGCCTGGCAGCCCTGGGGCCTGAGGGGGCC
CATGGTGACACTACCTTTGAGTACCAGGACCTGTGCCGCCAGCACATGGCCACGAAGTCC
TTGTTCAACCGGGCAGAGGGTCCACCGGAGCCTTCACGGGTGAGCAGTGTGTCCTCCCAG
TTCAGCGACGCAGCCCAGGCCAGCCCCAGCTCCCACAGCAGCACCCCGTCCTGGTGCGAG
GAGCCGGCCCAAGCCAACATGGACATCTCCACGGGACACATGATTCTGGCATACATGGAG
GATCACCTGCGGAACCGGGACCGCCTTGCCAAGGAGTGGCAGGCCCTCTGTGCCTACCAA
GCAGAGCCAAACACCTGTGCCACCGCGCAGGGGGAGGGCAACATCAAAAAGAACCGGCAT
CCTGACTTCCTGCCCTATGACCATGCCCGCATAAAACTGAAGGTGGAGAGCAGCCCTTCT
CGGAGCGATTACATCAACGCCAGCCCCATTATTGAGCATGACCCTCGGATGCCAGCCTAC
ATAGCCACGCAGGGCCCGCTGTCCCATACCATCGCAGACTTCTGGCAGATGGTGTGGGAG
AGCGGCTGCACCGTCATCGTCATGCTGACCCCGCTGGTGGAGGATGGTGTCAAGCAGTGT
GACCGCTACTGGCCAGATGAGGGTGCCTCCCTCTACCACGTATATGAGGTGAACCTGGTG
TCGGAGCACATCTGGTGCGAGGACTTTCTGGTGCGGAGCTTCTACCTGAAGAACGTGCAG
ACCCAGGAGACGCGCACGCTCACGCAGTTCCACTTCCTCAGCTGGCCGGCAGAGGGCACA
CCGGCCTCCACGCGGCCCCTGCTGGACTTCCGCAGGAAGGTGAACAAGTGCTACCGGGGC
CGCTCCTGCCCCATCATCGTGCACTGCAGTGATGGTGCGGGGAGGACCGGCACCTACATC
CTCATCGACATGGTCCTGAACCGCATGGCAAAAGGAGTGAAGGAGATTGACATCGCTGCC
ACCCTGGAGCATGTCCGTGACCAGCGGCCTGGCCTTGTCCGCTCTAAGGACCAGTTTGAA
TTTGCCCTGACAGCCGTGGCGGAGGAAGTGAATGCCATCCTCAAGGCCCTGCCCCAGTGA
Protein Properties
Number of Residues 979
Molecular Weight 105846.5
Theoretical pI 7.12
Pfam Domain Function
Signals
  • ["1-34"]
Transmembrane Regions
  • ["576-600"]
Protein Sequence
>Receptor-type tyrosine-protein phosphatase-like N
MRRPRRPGGLGGSGGLRLLLCLLLLSSRPGGCSAVSAHGCLFDRRLCSHLEVCIQDGLFG
QCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPE
PRPRDRSGLAPKRPGPAGELLLQDIPTGSAPAAQHRLPQPPVGKGGAGASSSLSPLQAEL
LPPLLEHLLLPPQPPHPSLSYEPALLQPYLFHQFGSRDGSRVSEGSPGMVSVGPLPKAEA
PALFSRTASKGIFGDHPGHSYGDLPGPSPAQLFQDSGLLYLAQELPAPSRARVPRLPEQG
SSSRAEDSPEGYEKEGLGDRGEKPASPAVQPDAALQRLAAVLAGYGVELRQLTPEQLSTL
LTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEGRDTAELPARTSPMPGHPTASPTSSE
VQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAAEEYGYIVTDQKP
LSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSE
LEAQTGLQILQTGVGQREEAAAVLPQTAHSTSPMRSVLLTLVALAGVAGLLVALAVALCV
RQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLFNRAEGPPEPSRVSSVSSQ
FSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQ
AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAY
IATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLV
SEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG
RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFE
FALTAVAEEVNAILKALPQ
GenBank ID Protein 62988650
UniProtKB/Swiss-Prot ID Q16849
UniProtKB/Swiss-Prot Entry Name PTPRN_HUMAN
PDB IDs Not Available
GenBank Gene ID AC114803
GeneCard ID PTPRN
GenAtlas ID PTPRN
HGNC ID HGNC:9676
References
General References Not Available