Cannabis Compound Database: Showing Protein Aminopeptidase B (CDBP04592)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04592

Secondary Accession Numbers

Not Available

Name

Aminopeptidase B

Description

Not Available

Synonyms

AP-B
Arginine aminopeptidase
Arginyl aminopeptidase

Gene Name

RNPEP

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(- 1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4)

GO Classification

Component
extracellular region part
extracellular space
Function
hydrolase activity
transition metal ion binding
zinc ion binding
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
exopeptidase activity
aminopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
Process
proteolysis
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process
metabolic process
macromolecule metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
leukotriene biosynthetic process
protein metabolic process

Cellular Location

Secreted

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q32

SNPs

RNPEP

Gene Sequence

>1953 bp
ATGGCGAGCGGCGAGCATTCCCCCGGCAGCGGCGCGGCCCGGCGGCCGCTGCACTCCGCG
CAGGCTGTGGACGTGGCCTCGGCCTCCAACTTCCGGGCCTTTGAGCTGCTGCACTTGCAC
CTGGACCTGCGGGCTGAGTTCGGGCCTCCAGGGCCCGGCGCAGGGAGCCGGGGGCTGAGC
GGCACCGCGGTCCTGGACCTGCGCTGCCTGGAGCCCGAGGGCGCCGCCGAGCTGCGGCTG
GACTCGCACCCGTGCCTGGAGGTGACGGCGGCGGCGCTGCGGCGGGAGCGGCCCGGCTCG
GAGGAGCCGCCTGCGGAGCCCGTGAGCTTCTACACGCAGCCCTTCTCGCACTATGGCCAG
GCCCTGTGCGTGTCCTTCCCGCAGCCCTGCCGCGCCGCCGAGCGCCTCCAGGTGCTGCTC
ACCTACCGCGTCGGGGAGGGACCCGGGGTTTGCTGGTTGGCTCCCGAGCAGACAGCAGGA
AAGAAGAAGCCCTTCGTGTACACCCAGGGCCAGGCTGTCCTAAACCGGGCCTTCTTCCCT
TGCTTCGACACGCCTGCTGTTAAATACAAGTATTCAGCTCTTATTGAGGTCCCAGATGGC
TTCACAGCTGTGATGAGTGCTAGCACCTGGGAGAAGAGAGGTCCAAATAAGTTCTTCTTC
CAGATGTGTCAGCCCATCCCCTCCTATCTGATAGCTTTGGCCATCGGAGATCTGGTTTCG
GCTGAAGTTGGACCCAGGAGCCGGGTGTGGGCTGAGCCCTGCCTGATTGATGCTGCCAAG
GAGGAGTACAACGGGGTGATAGAAGAATTTTTGGCAACAGGAGAGAAGCTTTTTGGACCT
TATGTTTGGGGAAGGTATGACTTGCTCTTCATGCCACCGTCCTTTCCATTTGGAGGAATG
GAGAACCCTTGTCTGACCTTTGTCACCCCCTGCCTGCTAGCTGGGGACCGCTCCTTGGCA
GATGTCATCATCCATGAGATCTCCCACAGTTGGTTTGGGAACCTGGTCACCAACGCCAAC
TGGGGTGAATTCTGGCTCAATGAAGGTTTCACCATGTACGCCCAGAGGAGGATCTCCACC
ATCCTCTTTGGCGCTGCGTACACCTGCTTGGAGGCTGCAACGGGGCGGGCTCTGCTGCGT
CAGCACATGGACATCACTGGAGAGGAAAACCCACTCAACAAGCTCCGCGTGAAGATTGAA
CCAGGCGTTGACCCGGACGACACCTATAATGAGACCCCCTACGAGAAAGGTTTCTGCTTT
GTCTCATACCTGGCCCACTTGGTGGGTGATCAGGATCAGTTTGACAGTTTTCTCAAGGCC
TATGTGCATGAATTCAAATTCCGAAGCATCTTAGCCGATGACTTTCTGGACTTCTACTTG
GAATATTTCCCTGAGCTTAAGAAAAAGAGAGTGGATATCATTCCAGGTTTTGAGTTTGAT
CGATGGCTGAATACCCCCGGCTGGCCCCCGTACCTCCCTGATCTCTCCCCTGGGGACTCA
CTCATGAAGCCTGCTGAAGAGCTAGCCCAACTGTGGGCAGCCGAGGAGCTGGACATGAAG
GCCATTGAAGCCGTGGCCATCTCTCCCTGGAAGACCTACCAGCTGGTCTACTTCCTGGAT
AAGATCCTCCAGAAATCCCCTCTCCCTCCTGGGAATGTGAAAAAACTTGGAGACACATAC
CCAAGTATCTCAAATGCCCGGAATGCAGAGCTCCGGCTGCGATGGGGCCAAATCGTCCTT
AAGAACGACCACCAGGAAGATTTCTGGAAAGTGAAGGAGTTCCTGCATAACCAGGGGAAG
CAGAAGTATACACTTCCGCTGTACCACGCAATGATGGGTGGCAGTGAGGTGGCCCAGACC
CTCGCCAAGGAGACTTTTGCATCCACCGCCTCCCAGCTCCACAGCAATGTTGTCAACTAT
GTCCAGCAGATCGTGGCACCCAAGGGCAGTTAG

Protein Properties

Number of Residues

650

Molecular Weight

72595.1

Theoretical pI

5.52

Pfam Domain Function

Peptidase_M1 (PF01433 )
Leuk-A4-hydro_C (PF09127 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Aminopeptidase B
MASGEHSPGSGAARRPLHSAQAVDVASASNFRAFELLHLHLDLRAEFGPPGPGAGSRGLS
GTAVLDLRCLEPEGAAELRLDSHPCLEVTAAALRRERPGSEEPPAEPVSFYTQPFSHYGQ
ALCVSFPQPCRAAERLQVLLTYRVGEGPGVCWLAPEQTAGKKKPFVYTQGQAVLNRAFFP
CFDTPAVKYKYSALIEVPDGFTAVMSASTWEKRGPNKFFFQMCQPIPSYLIALAIGDLVS
AEVGPRSRVWAEPCLIDAAKEEYNGVIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGM
ENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQRRIST
ILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCF
VSYLAHLVGDQDQFDSFLKAYVHEFKFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFD
RWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQLVYFLD
KILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGK
QKYTLPLYHAMMGGSEVAQTLAKETFASTASQLHSNVVNYVQQIVAPKGS

External Links

GenBank ID Protein

40316915

UniProtKB/Swiss-Prot ID

Q9H4A4

UniProtKB/Swiss-Prot Entry Name

AMPB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_020216.3

GeneCard ID