| Identification |
|---|
| HMDB Protein ID
| CDBP04568 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cell division protein kinase 20 |
| Description
| Not Available |
| Synonyms
|
- CAK-kinase p42
- CDK-activating kinase p42
- Cell cycle-related kinase
- Cyclin-dependent protein kinase H
- Cyclin-kinase-activating kinase p42
|
| Gene Name
| CDK20 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein kinase activity |
| Specific Function
| Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' |
| GO Classification
|
| Function |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cell projection
- cilium
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q22.1 |
| SNPs
| CDK20 |
| Gene Sequence
|
>1041 bp
ATGGACCAGTACTGCATCCTGGGCCGCATCGGGGAGGGCGCCCACGGCATCGTCTTCAAG
GCCAAGCACGTGGAGACTGGCGAGATAGTTGCCCTCAAGAAGGTGGCCCTAAGGCGGTTG
GAAGACGGCTTCCCTAACCAGGCCCTGCGGGAGATTAAGGCTCTGCAGGAGATGGAGGAC
AATCAGTATGTGGTACAACTGAAGGCTGTGTTCCCACACGGTGGAGGCTTTGTGCTGGCC
TTTGAGTTCATGCTGTCGGATCTGGCCGAGGTGGTGCGCCATGCCCAGAGGCCACTAGCC
CAGGCACAGGTCAAGAGCTACCTGCAGATGCTGCTCAAGGGTGTCGCCTTCTGCCATGCC
AACAACATTGTACATCGGGACCTGAAACCTGCCAACCTGCTCATCAGCGCCTCAGGCCAG
CTCAAGATAGCGGACTTTGGCCTGGCTCGAGTCTTTTCCCCAGACGGCAGCCGCCTCTAC
ACACACCAGGTGGCCACCAGGTGGTACCGAGCCCCCGAGCTCCTGTATGGTGCCCGCCAG
TATGACCAGGGCGTCGATCTGTGGTCTGTGGGCTGCATCATGGGGGAGCTGTTGAATGGG
TCCCCCCTTTTCCCGGGCAAGAACGATATTGAACAGCTTTGCTATGTGCTTCGCATCTTG
GGCACCCCAAACCCTCAAGTCTGGCCGGAGCTCACTGAGCTGCCGGACTACAACAAGATC
TCCTTTAAGGAGCAGGTGCCCATGCCCCTGGAGGAGGTGCTGCCTGACGTCTCTCCCCAG
GCATTGGATCTGCTGGGTCAATTCCTTCTCTACCCTCCTCACCAGCGCATCGCAGCTTCC
AAGGCTCTCCTCCATCAGTACTTCTTCACAGCTCCCCTGCCTGCCCATCCATCTGAGCTG
CCGATTCCTCAGCGTCTAGGGGGACCTGCCCCCAAGGCCCATCCAGGGCCCCCCCACATC
CATGACTTCCACGTGGACCGGCCTCTTGAGGAGTCGCTGTTGAACCCAGAGCTGATTCGG
CCCTTCATCCTGGAGGGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 346 |
| Molecular Weight
| 38694.5 |
| Theoretical pI
| 6.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cell division protein kinase 20
MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED
NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA
NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ
YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI
SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSEL
PIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG
|
| External Links |
|---|
| GenBank ID Protein
| 23344742 |
| UniProtKB/Swiss-Prot ID
| Q8IZL9 |
| UniProtKB/Swiss-Prot Entry Name
| CDK20_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF547664 |
| GeneCard ID
| CDK20 |
| GenAtlas ID
| CDK20 |
| HGNC ID
| HGNC:21420 |
| References |
|---|
| General References
| Not Available |