Identification
HMDB Protein ID CDBP04530
Secondary Accession Numbers Not Available
Name Dual serine/threonine and tyrosine protein kinase
Description Not Available
Synonyms
  1. Dusty PK
  2. Dusty protein kinase
  3. RIP-homologous kinase
  4. Receptor-interacting serine/threonine-protein kinase 5
  5. SgK496
  6. Sugen kinase 496
Gene Name DSTYK
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May induce both caspase-dependent apoptosis and caspase- independent cell death
GO Classification
Function
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.1
SNPs DSTYK
Gene Sequence
>2790 bp
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGC
GGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGG
CTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGAT
GTCGCCGAAACCGGGCTGCAGGCGGGCCAACTGAGCTGCATTTCCTTCCCACCTAAGGAA
GAGAAGTACCTCCAGCAGATTGTGGACTGCCTCCCTTGCATACTGATCCTCGGCCAGGAT
TGTAACGTCAAGTGCCAGCTGTTGAATCTGCTGTTGGGGGTGCAGGTGCTTCCCACCACC
AAGCTGGGCAGTGAGGAGAGCTGTAAGCTTCGGCGCCTCCGCTTCACCTATGGGACTCAG
ACTCGGGTCAGCCTGGCGCTCCCTGGACAGTATGAACTAGTGCACACGCTGGTTGCTCAT
CAGGGCAACTGGGAGACCATCCCTGAGGAGGATCTGGAGGTCCAAGAGAACAATGAGGAT
GCTGCTCATGTTTTAGCGGAACTGGAGGTAACGATGCACCATGCTCTCTTACAGGAAGTG
GACGTTGTGGTAGCACCATGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGGGTGACTTG
GTGAATGATTTCTTGCCTGTGATAACCTATGCACTCCACAAAGATGAACTCTCTGAGAGG
GATGAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCTGTATTCTTTTTCAAA
GTGCCGAAACTGGGCTCGGAGATAATAGACTCCTCAACCAGGAGAATGGAGAGCGAAAGA
TCACCGCTTTATCGCCAGCTAATTGACCTGGGCTATCTGAGCAGCAGTCACTGGAACTGT
GGGGCTCCTGGCCAGGATACTAAAGCTCAGAGCATGTTGGTGGAACAGAGTGAAAAGCTG
AGACACTTGAGCACATTTTCTCACCAGGTGTTACAGACTCGCCTGGTGGATGCAGCCAAG
GCCCTGAACCTGGTGCACTGCCACTGCCTTGACATCTTTATTAACCAGGCATTTGACATG
CAGCGGGACCTGCAGATCACTCCCAAACGTCTGGAATATACTCGAAAAAAGGAGAATGAG
TTGTATGAATCATTGATGAATATTGCCAACCGAAAGCAGGAGGAAATGAAGGATATGATT
GTTGAGACACTTAATACCATGAAGGAGGAACTTCTGGATGATGCTACTAACATGGAGTTT
AAAGACGTCATTGTCCCTGAGAATGGAGAACCAGTAGGCACCAGAGAGATCAAATGCTGC
ATCCGACAGATCCAGGAACTCATCATCTCCCGACTTAATCAGGCAGTGGCTAATAAGCTG
ATCAGCTCAGTGGATTACCTGAGGGAAAGCTTCGTCGGAACCCTGGAACGATGTCTGCAG
AGCCTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATC
TTAAATGCTGCCTATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATG
CTATGGGAGCAAATCAAACAGATCATCCAGCGCATCACATGGGTGAGCCCACCTGCCATC
ACTCTGGAATGGAAGAGGAAGGTGGCCCAGGAAGCCATTGAGAGCCTCAGCGCCTCCAAA
TTGGCTAAGAGCATTTGCAGCCAATTCCGGACTCGGCTCAATAGTTCCCACGAGGCTTTT
GCAGCCTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTAGAGAAAACGGAAGAT
CTATGGCTGAGGGTTCGGAAAGATCATGCTCCCCGCCTGGCCCGCCTTTCTCTGGAAAGC
TGTTCTTTACAGGATGTCTTGCTTCATCGTAAACCTAAACTGGGACAGGAACTGGGCCGG
GGCCAGTATGGTGTGGTATACCTGTGTGACAACTGGGGAGGACACTTCCCTTGTGCCCTC
AAATCAGTTGTCCCTCCAGATGAGAAGCACTGGAATGATCTGGCTTTGGAATTTCACTAT
ATGAGGTCTCTGCCGAAGCATGAGCGATTGGTGGATCTCCATGGTTCAGTCATTGACTAC
AACTATGGTGGTGGCTCCAGCATTGCTGTGCTCCTCATTATGGAGCGGCTACACCGGGAT
CTCTACACAGGGCTGAAGGCTGGGCTGACCCTGGAGACACGTTTGCAGATAGCACTAGAT
GTGGTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCATCGTGATATCAAACTG
AAAAATGTGCTGCTGGATAAGCAGAACCGTGCCAAGATCACTGACTTAGGATTCTGCAAG
CCAGAGGCCATGATGTCAGGCAGCATTGTGGGGACACCAATCCATATGGCCCCTGAACTT
TTCACAGGGAAGTACGATAATTCCGTGGATGTCTACGCTTTTGGAATTCTTTTCTGGTAT
ATCTGCTCAGGCTCTGTCAAGCTCCCTGAGGCATTTGAGAGGTGTGCTAGCAAAGACCAT
CTCTGGAACAATGTGCGGAGGGGGGCTCGCCCAGAACGTCTTCCTGTGTTTGATGAGGAG
TGCTGGCAGTTGATGGAAGCCTGTTGGGATGGCGACCCCTTGAAGAGGCCTCTCTTGGGC
ATTGTCCAGCCCATGCTCCAGGGCATCATGAATCGGCTCTGCAAGTCCAATTCTGAGCAG
CCAAACAGAGGACTAGATGATTCTACTTGA
Protein Properties
Number of Residues 929
Molecular Weight 105204.7
Theoretical pI 6.72
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Dual serine/threonine and tyrosine protein kinase
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN
HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD
CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH
QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL
VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER
SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK
ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI
VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL
ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM
LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF
AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR
GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY
NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL
KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY
ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG
IVQPMLQGIMNRLCKSNSEQPNRGLDDST
GenBank ID Protein 40806179
UniProtKB/Swiss-Prot ID Q6XUX3
UniProtKB/Swiss-Prot Entry Name DUSTY_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015375.2
GeneCard ID DSTYK
GenAtlas ID DSTYK
HGNC ID HGNC:29043
References
General References Not Available