Identification |
HMDB Protein ID
| CDBP04530 |
Secondary Accession Numbers
| Not Available |
Name
| Dual serine/threonine and tyrosine protein kinase |
Description
| Not Available |
Synonyms
|
- Dusty PK
- Dusty protein kinase
- RIP-homologous kinase
- Receptor-interacting serine/threonine-protein kinase 5
- SgK496
- Sugen kinase 496
|
Gene Name
| DSTYK |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase activity |
Specific Function
| May induce both caspase-dependent apoptosis and caspase- independent cell death |
GO Classification
|
Function |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
protein kinase activity |
protein serine/threonine kinase activity |
binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
Process |
phosphorus metabolic process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 1q32.1 |
SNPs
| DSTYK |
Gene Sequence
|
>2790 bp
ATGGAGGGCGACGGGGTGCCATGGGGCAGCGAGCCCGTCTCGGGTCCCGGCCCCGGCGGC
GGCGGAATGATCCGCGAGCTGTGCCGGGGCTTCGGCCGCTACCGCCGCTACCTGGGACGG
CTGCGACAGAACCTGCGCGAGACCCAGAAGTTCTTCCGCGACATCAAGTGCTCCCACAAC
CACACTTGTCTCTCCTCCCTCACGGGCGGCGGCGGGGCCGAGCGCGGCCCTGCAGGCGAT
GTCGCCGAAACCGGGCTGCAGGCGGGCCAACTGAGCTGCATTTCCTTCCCACCTAAGGAA
GAGAAGTACCTCCAGCAGATTGTGGACTGCCTCCCTTGCATACTGATCCTCGGCCAGGAT
TGTAACGTCAAGTGCCAGCTGTTGAATCTGCTGTTGGGGGTGCAGGTGCTTCCCACCACC
AAGCTGGGCAGTGAGGAGAGCTGTAAGCTTCGGCGCCTCCGCTTCACCTATGGGACTCAG
ACTCGGGTCAGCCTGGCGCTCCCTGGACAGTATGAACTAGTGCACACGCTGGTTGCTCAT
CAGGGCAACTGGGAGACCATCCCTGAGGAGGATCTGGAGGTCCAAGAGAACAATGAGGAT
GCTGCTCATGTTTTAGCGGAACTGGAGGTAACGATGCACCATGCTCTCTTACAGGAAGTG
GACGTTGTGGTAGCACCATGCCAAGGCCTCCGGCCCACAGTGGATGTTCTGGGTGACTTG
GTGAATGATTTCTTGCCTGTGATAACCTATGCACTCCACAAAGATGAACTCTCTGAGAGG
GATGAGCAAGAGCTTCAGGAAATCCGAAAGTATTTCTCCTTTCCTGTATTCTTTTTCAAA
GTGCCGAAACTGGGCTCGGAGATAATAGACTCCTCAACCAGGAGAATGGAGAGCGAAAGA
TCACCGCTTTATCGCCAGCTAATTGACCTGGGCTATCTGAGCAGCAGTCACTGGAACTGT
GGGGCTCCTGGCCAGGATACTAAAGCTCAGAGCATGTTGGTGGAACAGAGTGAAAAGCTG
AGACACTTGAGCACATTTTCTCACCAGGTGTTACAGACTCGCCTGGTGGATGCAGCCAAG
GCCCTGAACCTGGTGCACTGCCACTGCCTTGACATCTTTATTAACCAGGCATTTGACATG
CAGCGGGACCTGCAGATCACTCCCAAACGTCTGGAATATACTCGAAAAAAGGAGAATGAG
TTGTATGAATCATTGATGAATATTGCCAACCGAAAGCAGGAGGAAATGAAGGATATGATT
GTTGAGACACTTAATACCATGAAGGAGGAACTTCTGGATGATGCTACTAACATGGAGTTT
AAAGACGTCATTGTCCCTGAGAATGGAGAACCAGTAGGCACCAGAGAGATCAAATGCTGC
ATCCGACAGATCCAGGAACTCATCATCTCCCGACTTAATCAGGCAGTGGCTAATAAGCTG
ATCAGCTCAGTGGATTACCTGAGGGAAAGCTTCGTCGGAACCCTGGAACGATGTCTGCAG
AGCCTGGAGAAGTCTCAGGATGTCTCAGTTCACATCACCAGTAATTATCTCAAACAGATC
TTAAATGCTGCCTATCATGTTGAAGTCACGTTTCACTCAGGGTCGTCAGTTACAAGGATG
CTATGGGAGCAAATCAAACAGATCATCCAGCGCATCACATGGGTGAGCCCACCTGCCATC
ACTCTGGAATGGAAGAGGAAGGTGGCCCAGGAAGCCATTGAGAGCCTCAGCGCCTCCAAA
TTGGCTAAGAGCATTTGCAGCCAATTCCGGACTCGGCTCAATAGTTCCCACGAGGCTTTT
GCAGCCTCCTTGCGGCAGCTGGAAGCTGGCCACTCAGGCCGGTTAGAGAAAACGGAAGAT
CTATGGCTGAGGGTTCGGAAAGATCATGCTCCCCGCCTGGCCCGCCTTTCTCTGGAAAGC
TGTTCTTTACAGGATGTCTTGCTTCATCGTAAACCTAAACTGGGACAGGAACTGGGCCGG
GGCCAGTATGGTGTGGTATACCTGTGTGACAACTGGGGAGGACACTTCCCTTGTGCCCTC
AAATCAGTTGTCCCTCCAGATGAGAAGCACTGGAATGATCTGGCTTTGGAATTTCACTAT
ATGAGGTCTCTGCCGAAGCATGAGCGATTGGTGGATCTCCATGGTTCAGTCATTGACTAC
AACTATGGTGGTGGCTCCAGCATTGCTGTGCTCCTCATTATGGAGCGGCTACACCGGGAT
CTCTACACAGGGCTGAAGGCTGGGCTGACCCTGGAGACACGTTTGCAGATAGCACTAGAT
GTGGTGGAGGGAATCCGCTTCCTGCACAGCCAGGGACTTGTCCATCGTGATATCAAACTG
AAAAATGTGCTGCTGGATAAGCAGAACCGTGCCAAGATCACTGACTTAGGATTCTGCAAG
CCAGAGGCCATGATGTCAGGCAGCATTGTGGGGACACCAATCCATATGGCCCCTGAACTT
TTCACAGGGAAGTACGATAATTCCGTGGATGTCTACGCTTTTGGAATTCTTTTCTGGTAT
ATCTGCTCAGGCTCTGTCAAGCTCCCTGAGGCATTTGAGAGGTGTGCTAGCAAAGACCAT
CTCTGGAACAATGTGCGGAGGGGGGCTCGCCCAGAACGTCTTCCTGTGTTTGATGAGGAG
TGCTGGCAGTTGATGGAAGCCTGTTGGGATGGCGACCCCTTGAAGAGGCCTCTCTTGGGC
ATTGTCCAGCCCATGCTCCAGGGCATCATGAATCGGCTCTGCAAGTCCAATTCTGAGCAG
CCAAACAGAGGACTAGATGATTCTACTTGA
|
Protein Properties |
Number of Residues
| 929 |
Molecular Weight
| 105204.7 |
Theoretical pI
| 6.72 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Dual serine/threonine and tyrosine protein kinase
MEGDGVPWGSEPVSGPGPGGGGMIRELCRGFGRYRRYLGRLRQNLRETQKFFRDIKCSHN
HTCLSSLTGGGGAERGPAGDVAETGLQAGQLSCISFPPKEEKYLQQIVDCLPCILILGQD
CNVKCQLLNLLLGVQVLPTTKLGSEESCKLRRLRFTYGTQTRVSLALPGQYELVHTLVAH
QGNWETIPEEDLEVQENNEDAAHVLAELEVTMHHALLQEVDVVVAPCQGLRPTVDVLGDL
VNDFLPVITYALHKDELSERDEQELQEIRKYFSFPVFFFKVPKLGSEIIDSSTRRMESER
SPLYRQLIDLGYLSSSHWNCGAPGQDTKAQSMLVEQSEKLRHLSTFSHQVLQTRLVDAAK
ALNLVHCHCLDIFINQAFDMQRDLQITPKRLEYTRKKENELYESLMNIANRKQEEMKDMI
VETLNTMKEELLDDATNMEFKDVIVPENGEPVGTREIKCCIRQIQELIISRLNQAVANKL
ISSVDYLRESFVGTLERCLQSLEKSQDVSVHITSNYLKQILNAAYHVEVTFHSGSSVTRM
LWEQIKQIIQRITWVSPPAITLEWKRKVAQEAIESLSASKLAKSICSQFRTRLNSSHEAF
AASLRQLEAGHSGRLEKTEDLWLRVRKDHAPRLARLSLESCSLQDVLLHRKPKLGQELGR
GQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDY
NYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQGLVHRDIKL
KNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWY
ICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPVFDEECWQLMEACWDGDPLKRPLLG
IVQPMLQGIMNRLCKSNSEQPNRGLDDST
|
External Links |
GenBank ID Protein
| 40806179 |
UniProtKB/Swiss-Prot ID
| Q6XUX3 |
UniProtKB/Swiss-Prot Entry Name
| DUSTY_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_015375.2 |
GeneCard ID
| DSTYK |
GenAtlas ID
| DSTYK |
HGNC ID
| HGNC:29043 |
References |
General References
| Not Available |