Identification |
HMDB Protein ID
| CDBP04526 |
Secondary Accession Numbers
| Not Available |
Name
| AP2-associated protein kinase 1 |
Description
| Not Available |
Synonyms
|
- Adaptor-associated kinase 1
|
Gene Name
| AAK1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein kinase activity |
Specific Function
| Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis |
GO Classification
|
Function |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
protein kinase activity |
protein serine/threonine kinase activity |
binding |
catalytic activity |
Process |
phosphorus metabolic process |
phosphate metabolic process |
metabolic process |
cellular metabolic process |
protein amino acid phosphorylation |
phosphorylation |
|
Cellular Location
|
- Cell membrane
- Peripheral membrane protein
- Peripheral membrane protein
- Membrane
- Membrane
- clathrin-coated pit
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 2p14 |
SNPs
| AAK1 |
Gene Sequence
|
>2886 bp
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCC
AGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGC
ATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAAT
GAGCATGATCTCCAGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCAC
AAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGAGTAGCGGTGATGTATGG
GAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAG
CGCCTGCAAACAGGCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAA
GCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACCGGGACCTGAAGGTTGAA
AACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAAC
AAATTCCAGAATCCACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATAC
ACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACAGTGGCAAAATCATCACT
ACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTG
CCATTTGGGGAAAGTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCT
CGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGGAACCAGACCCTGACAAA
AGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCA
ATTCCAAATGTACAGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGT
GAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAGATCCCATTCCCACCACA
GAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGA
ATCCTTCCCATCCAGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCT
CAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTGTTCCCCAACCAAAACCC
CAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCC
ACTCCACAGCAGACGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACA
CCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGCAGCAACAGCCACCGCCA
GCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTT
CAGGCAGTACATCCAGCAACCCAGCAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAA
GGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGCAGCAGCAGCAGCAACAA
CAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAG
GCTGCCTTGCAGCAAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCT
GCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAGCCCCAGTAAGACAACAG
CCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACT
CCACCCTCATCCCCCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACC
CACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGCTGCTCCAGGCAGCTGCA
GCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGG
ACCTCTCAACAAAACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGAC
GATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGGACTTTGCCAAGCTTGGG
GAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAA
TCAACCCAAGGTGATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGCTGAAAAAAGG
AAGGGTGGGCAGACTGTGGACTCTGGCCTCCCGCTTCTAAGCGTGTCTGATCCTTTCATT
CCTCTTCAAGTACCTGATGCACCAGAAAAACTAATTGAGGGACTCAAATCTCCTGACACT
TCTCTTCTGCTCCCTGACCTCTTGCCTATGACAGATCCTTTTGGTAGCACTTCTGATGCT
GTAATTGAAAAAGCTGATGTTGCTGTTGAGAGTCTCATACCAGGACTGGAGCCCCCAGTT
CCCCAGCGCCTCCCATCTCAGACGGAATCTGTGACCTCGAATCGCACAGATTCTCTCACC
GGGGAAGATTCCCTGCTTGATTGCTCTCTGCTCTCTAACCCTACTACTGACCTTCTGGAA
GAGTTTGCCCCCACAGCAATCTCTGCTCCAGTCCATAAAGCTGCAGAAGATAGTAATCTC
ATCTCAGGTTTTGATGTCCCTGAGGGCTCGGACAAGGTGGCTGAAGATGAGTTTGACCCT
ATTCCTGTATTGATAACCAAAAACCCACAAGGTGGGCACTCTAGAAACAGCAGTGGGAGC
TCTGAGTCCAGTCTTCCCAACCTAGCCAGGTCTTTACTGCTGGTGGATCAGCTCATAGAC
CTGTAG
|
Protein Properties |
Number of Residues
| 961 |
Molecular Weight
| 103884.3 |
Theoretical pI
| 6.57 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>AP2-associated protein kinase 1
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
|
External Links |
GenBank ID Protein
| 148277037 |
UniProtKB/Swiss-Prot ID
| Q2M2I8 |
UniProtKB/Swiss-Prot Entry Name
| AAK1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_014911.3 |
GeneCard ID
| AAK1 |
GenAtlas ID
| AAK1 |
HGNC ID
| HGNC:19679 |
References |
General References
| Not Available |