Identification
HMDB Protein ID CDBP04526
Secondary Accession Numbers Not Available
Name AP2-associated protein kinase 1
Description Not Available
Synonyms
  1. Adaptor-associated kinase 1
Gene Name AAK1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function Phosphorylates the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2). May play a role in regulating aspects of clathrin-mediated endocytosis
GO Classification
Function
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
protein kinase activity
protein serine/threonine kinase activity
binding
catalytic activity
Process
phosphorus metabolic process
phosphate metabolic process
metabolic process
cellular metabolic process
protein amino acid phosphorylation
phosphorylation
Cellular Location
  1. Cell membrane
  2. Peripheral membrane protein
  3. Peripheral membrane protein
  4. Membrane
  5. Membrane
  6. clathrin-coated pit
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2p14
SNPs AAK1
Gene Sequence
>2886 bp
ATGAAGAAGTTTTTCGACTCCCGGCGAGAGCAGGGCGGCTCTGGCCTGGGCTCCGGCTCC
AGCGGAGGAGGGGGCAGCACCTCGGGCCTGGGCAGTGGCTACATCGGAAGAGTCTTCGGC
ATCGGGCGACAGCAGGTCACAGTGGACGAGGTGTTGGCGGAAGGTGGATTTGCTATTGTA
TTTCTGGTGAGGACAAGCAATGGGATGAAATGTGCCTTGAAACGCATGTTTGTCAACAAT
GAGCATGATCTCCAGGTGTGCAAGAGAGAAATCCAGATAATGAGGGATCTTTCAGGGCAC
AAGAATATTGTGGGTTACATTGATTCTAGTATCAACAACGTGAGTAGCGGTGATGTATGG
GAAGTGCTCATTCTGATGGACTTTTGTAGAGGTGGCCAGGTGGTAAACCTGATGAACCAG
CGCCTGCAAACAGGCTTTACAGAGAATGAAGTGCTCCAGATATTTTGTGATACCTGTGAA
GCTGTTGCCCGCCTGCATCAGTGCAAAACTCCTATTATCCACCGGGACCTGAAGGTTGAA
AACATCCTCTTGCATGACCGAGGCCACTATGTCCTGTGTGACTTTGGAAGCGCCACCAAC
AAATTCCAGAATCCACAAACTGAGGGAGTCAATGCAGTAGAAGATGAGATTAAGAAATAC
ACAACGCTGTCCTATCGAGCACCAGAAATGGTCAACCTGTACAGTGGCAAAATCATCACT
ACGAAGGCAGACATTTGGGCTCTTGGATGTTTGTTGTATAAATTATGCTACTTCACTTTG
CCATTTGGGGAAAGTCAGGTGGCAATTTGTGATGGAAACTTCACAATTCCTGATAATTCT
CGATATTCTCAAGACATGCACTGCCTAATTAGGTATATGTTGGAACCAGACCCTGACAAA
AGGCCGGATATTTACCAGGTGTCCTACTTCTCATTTAAGCTACTCAAGAAAGAGTGCCCA
ATTCCAAATGTACAGAACTCTCCCATTCCTGCAAAGCTTCCTGAACCAGTGAAAGCCAGT
GAGGCAGCTGCAAAAAAGACCCAGCCAAAGGCCAGACTGACAGATCCCATTCCCACCACA
GAGACTTCAATTGCACCCCGCCAGAGGCCTAAAGCTGGGCAGACTCAGCCGAACCCAGGA
ATCCTTCCCATCCAGCCAGCGCTGACACCCCGGAAGAGGGCCACTGTTCAGCCCCCACCT
CAGGCTGCAGGATCCAGCAATCAGCCTGGCCTTTTAGCCAGTGTTCCCCAACCAAAACCC
CAAGCCCCACCCAGCCAGCCTCTGCCGCAAACTCAGGCCAAGCAGCCACAGGCTCCTCCC
ACTCCACAGCAGACGCCTTCTACTCAGGCCCAGGGTCTGCCCGCTCAGGCCCAGGCCACA
CCCCAGCACCAGCAGCAACTCTTCCTCAAGCAGCAACAGCAGCAGCAACAGCCACCGCCA
GCACAGCAGCAGCCGGCAGGCACGTTTTACCAGCAGCAGCAGGCCCAGACTCAGCAGTTT
CAGGCAGTACATCCAGCAACCCAGCAACCAGCAATTGCTCAGTTCCCTGTGGTGTCCCAA
GGAGGCTCTCAACAGCAGCTAATGCAGAATTTCTACCAGCAGCAGCAGCAGCAGCAACAA
CAACAGCAACAGCAACAGCTGGCCACAGCCCTGCATCAACAACAGCTGATGACTCAGCAG
GCTGCCTTGCAGCAAAAGCCCACTATGGCAGCAGGACAGCAGCCCCAGCCACAGCCAGCT
GCAGCCCCACAGCCAGCCCCTGCCCAGGAGCCAGCGATTCAAGCCCCAGTAAGACAACAG
CCAAAGGTTCAGACAACCCCACCTCCTGCCGTCCAGGGGCAGAAAGTTGGATCTCTCACT
CCACCCTCATCCCCCAAAACCCAACGTGCTGGGCACAGGCGTATTCTCAGTGACGTAACC
CACAGTGCAGTCTTTGGGGTCCCTGCCAGCAAATCAACCCAGCTGCTCCAGGCAGCTGCA
GCTGAGGCCAGTCTCAATAAGTCCAAGTCTGCAACCACCACTCCATCAGGCTCTCCTCGG
ACCTCTCAACAAAACGTTTATAATCCTTCAGAAGGGTCTACGTGGAATCCCTTTGATGAC
GATAATTTCTCCAAACTCACAGCTGAAGAACTGCTAAACAAGGACTTTGCCAAGCTTGGG
GAAGGCAAACATCCCGAGAAGCTTGGAGGCTCAGCTGAGAGTTTGATCCCAGGCTTTCAA
TCAACCCAAGGTGATGCTTTTGCTACGACCTCATTTTCTGCTGGAACTGCTGAAAAAAGG
AAGGGTGGGCAGACTGTGGACTCTGGCCTCCCGCTTCTAAGCGTGTCTGATCCTTTCATT
CCTCTTCAAGTACCTGATGCACCAGAAAAACTAATTGAGGGACTCAAATCTCCTGACACT
TCTCTTCTGCTCCCTGACCTCTTGCCTATGACAGATCCTTTTGGTAGCACTTCTGATGCT
GTAATTGAAAAAGCTGATGTTGCTGTTGAGAGTCTCATACCAGGACTGGAGCCCCCAGTT
CCCCAGCGCCTCCCATCTCAGACGGAATCTGTGACCTCGAATCGCACAGATTCTCTCACC
GGGGAAGATTCCCTGCTTGATTGCTCTCTGCTCTCTAACCCTACTACTGACCTTCTGGAA
GAGTTTGCCCCCACAGCAATCTCTGCTCCAGTCCATAAAGCTGCAGAAGATAGTAATCTC
ATCTCAGGTTTTGATGTCCCTGAGGGCTCGGACAAGGTGGCTGAAGATGAGTTTGACCCT
ATTCCTGTATTGATAACCAAAAACCCACAAGGTGGGCACTCTAGAAACAGCAGTGGGAGC
TCTGAGTCCAGTCTTCCCAACCTAGCCAGGTCTTTACTGCTGGTGGATCAGCTCATAGAC
CTGTAG
Protein Properties
Number of Residues 961
Molecular Weight 103884.3
Theoretical pI 6.57
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>AP2-associated protein kinase 1
MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIV
FLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVW
EVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE
NILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIIT
TKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDK
RPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT
ETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKP
QAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPP
AQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQ
QQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQ
PKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAA
AEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLG
EGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFI
PLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPV
PQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNL
ISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLID
L
GenBank ID Protein 148277037
UniProtKB/Swiss-Prot ID Q2M2I8
UniProtKB/Swiss-Prot Entry Name AAK1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_014911.3
GeneCard ID AAK1
GenAtlas ID AAK1
HGNC ID HGNC:19679
References
General References Not Available