Identification |
HMDB Protein ID
| CDBP04516 |
Secondary Accession Numbers
| Not Available |
Name
| AXL receptor tyrosine kinase |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| AXL |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate |
GO Classification
|
Function |
adenyl nucleotide binding |
atp binding |
protein-tyrosine kinase activity |
protein kinase activity |
purine nucleotide binding |
binding |
nucleotide binding |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
kinase activity |
Process |
biopolymer metabolism |
biopolymer modification |
protein modification |
physiological process |
metabolism |
macromolecule metabolism |
protein amino acid phosphorylation |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:19 |
Locus
| 19q13.1 |
SNPs
| Q8N5L2 |
Gene Sequence
|
>2685 bp
ATGGCGTGGCGGTGCCCCAGGATGGGCAGGGTCCCGCTGGCCTGGTGCTTGGCGCTGTGC
GGCTGGGCGTGCATGGCCCCCAGGGGCACGCAGGCTGAAGAAAGTCCCTTCGTGGGCAAC
CCAGGGAATATCACAGGTGCCCGGGGACTCACGGGCACCCTTCGGTGTCAGCTCCAGGTT
CAGGGAGAGCCCCCCGAGGTACATTGGCTTCGGGATGGACAGATCCTGGAGCTCGCGGAC
AGCACCCAGACCCAGGTGCCCCTGGGTGAGGATGAACAGGATGACTGGATAGTGGTCAGC
CAGCTCAGAATCACCTCCCTGCAGCTTTCCGACACGGGACAGTACCAGTGTTTGGTGTTT
CTGGGACATCAGACCTTCGTGTCCCAGCCTGGCTATGTTGGGCTGGAGGGCTTGCCTTAC
TTCCTGGAGGAGCCCGAAGACAGGACTGTGGCCGCCAACACCCCCTTCAACCTGAGCTGC
CAAGCTCAGGGACCCCCAGAGCCCGTGGACCTACTCTGGCTCCAGGATGCTGTCCCCCTG
GCCACGGCTCCAGGTCACGGCCCCCAGCGCAGCCTGCATGTTCCAGGGCTGAACAAGACA
TCCTCTTTCTCCTGCGAAGCCCATAACGCCAAGGGGGTCACCACATCCCGCACAGCCACC
ATCACAGTGCTCCCCCAGCAGCCCCGTAACCTCCACCTGGTCTCCCGCCAACCCACGGAG
CTGGAGGTGGCTTGGACTCCAGGCCTGAGCGGCATCTACCCCCTGACCCACTGCACCCTG
CAGGCTGTGCTGTCAGACGATGGGATGGGCATCCAGGCGGGAGAACCAGACCCCCCAGAG
GAGCCCCTCACCTCGCAAGCATCCGTGCCCCCCCATCAGCTTCGGCTAGGCAGCCTCCAT
CCTCACACCCCTTATCACATCCGCGTGGCATGCACCAGCAGCCAGGGCCCCTCATCCTGG
ACCCACTGGCTTCCTGTGGAGACGCCGGAGGGAGTGCCCCTGGGCCCCCCTGAGAACATT
AGTGCTACGCGGAATGGGAGCCAGGCCTTCGTGCATTGGCAAGAGCCCCGGGCGCCCCTG
CAGGGTACCCTGTTAGGGTACCGGCTGGCGTATCAAGGCCAGGACACCCCAGAGGTGCTA
ATGGACATAGGGCTAAGGCAAGAGGTGACCCTGGAGCTGCAGGGGGACGGGTCTGTGTCC
AATCTGACAGTGTGTGTGGCAGCCTACACTGCTGCTGGGGATGGACCCTGGAGCCTCCCA
GTACCCCTGGAGGCCTGGCGCCCAGGGCAAGCACAGCCAGTCCACCAGCTGGTGAAGGAA
CCTTCAACTCCTGCCTTCTCGTGGCCCTGGTGGTATGTACTGCTAGGAGCAGTCGTGGCC
GCTGCCTGTGTCCTCATCTTGGCTCTCTTCCTTGTCCACCGGCGAAAGAAGGAGACCCGT
TATGGAGAAGTGTTTGAACCAACAGTGGAAAGAGGTGAACTGGTAGTCAGGTACCGCGTG
CGCAAGTCCTACAGTCGTCGGACCACTGAAGCTACCTTGAACAGCTTGGGCATCAGTGAA
GAGCTGAAGGAGAAGCTGCGGGATGTGATGGTGGACCGGCACAAGGTGGCCCTGGGGAAG
ACTCTGGGAGAGGGAGAGTTTGGAGCTGTGATGGAAGGCCAGCTCAACCAGGACGACTCC
ATCCTCAAGGTGGCTGTGAAGACGATGAAGATTGCCATCTGCACGAGGTCAGAGCTGGAG
GATTTCCTGAGTGAAGCGGTCTGCATGAAGGAATTTGACCATCCCAACGTCATGAGGCTC
ATCGGTGTCTGTTTCCAGGGTTCTGAACGAGAGAGCTTCCCAGCACCTGTGGTCATCTTA
CCTTTCATGAAACATGGAGACCTACACAGCTTCCTCCTCTATTCCCGGCTCGGGGACCAG
CCAGTGTACCTGCCCACTCAGATGCTAGTGAAGTTCATGGCAGACATCGCCAGTGGCATG
GAGTATCTGAGTACCAAGAGATTCATACACCGGGACCTGGCGGCCAGGAACTGCATGCTG
AATGAGAACATGTCCGTGTGTGTGGCGGACTTCGGGCTCTCCAAGAAGATCTACAATGGG
GACTACTACCGCCAGGGACGTATCGCCAAGATGCCAGTCAAGTGGATTGCCATTGAGAGT
CTAGCTGACCGTGTCTACACCAGCAAGAGCGATGTGTGGTCCTTCGGGGTGACAATGTGG
GAGATTGCCACAAGAGGCCAAACCCCATATCCGGGCGTGGAGAACAGCGAGATTTATGAC
TATCTGCGCCGGGGAAATCGCCTGAAGCAGCCTGCGGACTGTCTGGATGGACTGTATGCC
TTGATGTCGCGGTGCTGGGAGCTAAATCCCCAGGACCGGCCAAGTTTTACAGAGCTGCGG
GAAGATTTGGAGAACACACTGAAGGCCTTGCCTCCTGCCCAGGAGCCTGACGAAATCCTC
TATGTCAACATGGATGAGGGTGGAGGTTATCCTGAACCCCCTGGAGCTGCAGGAGGAGCT
GACCCCCCAACCCAGCCAGACCCTAAGGATTCCTGTAGCTGCCTCACTGCGGCTGAGGTC
CATCCTGCTGGACGCTATGTCCTCTGCCCTTCCACAACCCCTAGCCCCGCTCAGCCTGCT
GATAGGGGCTCCCCAGCAGCCCCAGGGCAGGAGGATGGTGCCTGA
|
Protein Properties |
Number of Residues
| 894 |
Molecular Weight
| 98366.0 |
Theoretical pI
| 5.11 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>AXL receptor tyrosine kinase
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQV
QGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVF
LGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPL
ATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTE
LEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLH
PHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPL
QGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLP
VPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETR
YGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGK
TLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRL
IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM
EYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIES
LADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRRGNRLKQPADCLDGLYA
LMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGA
DPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
|
External Links |
GenBank ID Protein
| 21619004 |
UniProtKB/Swiss-Prot ID
| P30530 |
UniProtKB/Swiss-Prot Entry Name
| Q8N5L2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| BC032229 |
GeneCard ID
| Q8N5L2 |
GenAtlas ID
| AXL |
HGNC ID
| HGNC:905 |
References |
General References
| Not Available |