Identification
HMDB Protein ID CDBP04481
Secondary Accession Numbers Not Available
Name Hyaluronidase-2
Description Not Available
Synonyms
  1. Hyal-2
  2. Hyaluronoglucosaminidase-2
  3. LuCa-2
  4. Lung carcinoma protein 2
Gene Name HYAL2
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
GO Classification
Biological Process
negative regulation of cell growth
monocyte activation
positive regulation of urine volume
negative regulation of protein kinase B signaling cascade
cartilage development
positive regulation of inflammatory response
response to antibiotic
positive regulation of interleukin-6 secretion
kidney development
positive regulation of interleukin-8 secretion
cellular response to transforming growth factor beta stimulus
positive regulation of protein import into nucleus
carbohydrate metabolic process
transformation of host cell by virus
viral entry into host cell via membrane fusion with the plasma membrane
response to reactive oxygen species
cellular response to tumor necrosis factor
hyaluronan catabolic process
small molecule metabolic process
cellular response to interleukin-1
positive regulation of apoptotic process
negative regulation of fibroblast migration
negative regulation of MAP kinase activity
renal water absorption
cellular response to UV-B
defense response to virus
cellular response to fibroblast growth factor stimulus
positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Golgi membrane
cytosol
membrane raft
endoplasmic reticulum
endocytic vesicle
perinuclear region of cytoplasm
lysosome
microvillus
anchored to external side of plasma membrane
apical plasma membrane
Function
hyalurononglucosaminidase activity
hexosaminidase activity
catalytic activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing o-glycosyl compounds
Molecular Function
viral receptor activity
hyalurononglucosaminidase activity
hyaluronic acid binding
hyaluronoglucuronidase activity
receptor signaling protein tyrosine kinase inhibitor activity
transforming growth factor beta binding
Process
metabolic process
primary metabolic process
carbohydrate metabolic process
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. GPI-anchor
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs HYAL2
Gene Sequence
>1416 bp
ATGCGGGCAGGCCCAGGCCCCACCGTTACATTGGCCCTGGTGCTGGCGGTGGCATGGGCC
ATGGAGCTCAAGCCCACAGCACCACCCATCTTCACTGGCCGGCCCTTTGTGGTAGCGTGG
GACGTGCCCACACAGGACTGTGGCCCACGCCTCAAGGTGCCACTGGACCTGAATGCCTTT
GATGTGCAGGCCTCACCTAATGAGGGTTTTGTGAACCAGAATATTACCATCTTCTACCGC
GACCGTCTAGGCCTGTATCCACGCTTCGATTCTGCCGGAAGGTCTGTGCATGGTGGTGTG
CCACAGAATGTCAGCCTTTGGGCACACCGGAAGATGCTGCAGAAACGTGTGGAGCACTAC
ATTCGGACACAGGAGTCTGCGGGGCTGGCGGTCATCGACTGGGAGGACTGGCGACCTGTG
TGGGTGCGCAACTGGCAGGACAAAGATGTGTATCGCCGGTTATCACGCCAGCTAGTGGCC
AGTCGTCACCCTGACTGGCCTCCAGACCGCATAGTCAAACAGGCACAATATGAGTTTGAG
TTCGCAGCACAGCAGTTCATGCTGGAGACACTGCGTTATGTCAAGGCAGTGCGGCCCCGG
CACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTACAATCATGATTATGTGCAGAACTGG
GAGAGCTACACAGGCCGCTGCCCTGATGTTGAGGTGGCCCGCAATGACCAGCTGGCCTGG
CTGTGGGCTGAGAGCACGGCCCTCTTCCCGTCTGTCTACCTGGACGAGACACTTGCTTCC
GCCCTCCATGGCCGCAACTTTGTGAGCTTCCGTGTTCAGGAGGCCCTTCGTGTGGCTCGC
ACCCACCATGCCAACCATGCACTCCCAGTCTACGTCTTCACACGACCCACCTACAGCCGC
TGCACGGGGCTTAGTGAGATGGACCTCATCTCTACCATTGGCGAGAGTGCGGCCCTGGGC
GCAGCTGGTGTCATCCTCTGGGGTGACGCGGGGTACACCACAAGCACGGAGACCTGCCAG
TACCTCAAAGATTACCTGACACGGCTGCTGGTCCCCTACGTGGTCAATGTGTCCTGGGCC
ACCCAATATTGCAGCCGGGCCCAGTGCCATGGCCATGGCTGTGTGCCCGGCAACCCCAGT
GCCAGTACCTTCCTGCATCTCAGCACCAACAGTTTCCGCCTAGTGCCTGGCCATGCACCT
GGTGAACCCCAGCTGCGACCTGTGGGGGAGCTCAGTTGGGCCGACATTGACCACCTGCAG
ACACACTTCCGCTGCCAGTGCTACTTGGGCTGGAGTGGTGAGCAATGCCAGTGGGACCAT
AGGCAGGCAGCTGGAGGTGCCAACGAGGCCTGGGCTGGGTCCCACCTCACCAGTCTGCTG
GCTCTGGCAGCCCTGGCCTTTACCTGGACCTTGTAG
Protein Properties
Number of Residues 473
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Hyaluronidase-2
MRAGPGPTVTLALVLAVAWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAF
DVQASPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHY
IRTQESAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRIVKQAQYEFE
FAAQQFMLETLRYVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAW
LWAESTALFPSVYLDETLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSR
RLTGLSEMDLISTIGESAALGAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSW
ATQYCSRAQCHGHGRCVRRNPSASTFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADIDH
LQTHFRCQCYLGWSGEQCQWDHRQAAGGASEAWAGSHLTSLLALAALAFTWTL
GenBank ID Protein 4378959
UniProtKB/Swiss-Prot ID Q12891
UniProtKB/Swiss-Prot Entry Name HYAL2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ000099
GeneCard ID HYAL2
GenAtlas ID HYAL2
HGNC ID HGNC:5321
References
General References Not Available