| Identification |
|---|
| HMDB Protein ID
| CDBP04479 |
| Secondary Accession Numbers
| Not Available |
| Name
| Hyaluronidase-1 |
| Description
| Not Available |
| Synonyms
|
- Hyal-1
- Hyaluronoglucosaminidase-1
- LuCa-1
- Lung carcinoma protein 1
|
| Gene Name
| HYAL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
|
| GO Classification
|
| Biological Process |
| positive regulation of epithelial cell proliferation |
| positive regulation of epithelial cell migration |
| inflammatory response |
| negative regulation of cell proliferation |
| response to reactive oxygen species |
| carbohydrate metabolic process |
| cellular response to tumor necrosis factor |
| cell death |
| hyaluronan catabolic process |
| chondroitin sulfate catabolic process |
| positive regulation of S phase of mitotic cell cycle |
| response to virus |
| cellular response to interleukin-1 |
| positive regulation of angiogenesis |
| cellular response to platelet-derived growth factor stimulus |
| hyaluronan biosynthetic process |
| positive regulation of hyaluranon cable assembly |
| positive regulation of cell growth |
| cellular response to pH |
| negative regulation of cell growth |
| cellular response to UV-B |
| cartilage development |
| positive regulation of cell adhesion |
| response to antibiotic |
| cellular response to fibroblast growth factor stimulus |
| Cellular Component |
| lysosomal lumen |
| hyaluranon cable |
| extracellular space |
| cytoplasmic vesicle |
| Function |
| hyalurononglucosaminidase activity |
| hexosaminidase activity |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| Molecular Function |
| transcription factor binding |
| hyaluronan synthase activity |
| hyalurononglucosaminidase activity |
| Process |
| metabolic process |
| primary metabolic process |
| carbohydrate metabolic process |
|
| Cellular Location
|
- Lysosome
- Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycosaminoglycan degradation | Not Available |  | | Lysosome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| HYAL1 |
| Gene Sequence
|
>1308 bp
ATGGCAGCCCACCTGCTTCCCATCTGCGCCCTCTTCCTGACCTTACTCGATATGGCCCAA
GGCTTTAGGGGCCCCTTGCTACCCAACCGGCCCTTCACCACCGTCTGGAATGCAAACACC
CAGTGGTGCCTGGAGAGGCACGGTGTGGACGTGGATGTCAGTGTCTTCGATGTGGTAGCC
AACCCAGGGCAGACCTTCCGCGGCCCTGACATGACAATTTTCTATAGCTCCCAGCTGGGC
ACCTACCCCTACTACACGCCCACTGGGGAGCCTGTGTTTGGTGGTCTGCCCCAGAATGCC
AGCCTGATTGCCCACCTGGCCCGCACATTCCAGGACATCCTGGCTGCCATACCTGCTCCT
GACTTCTCAGGGCTGGCAGTCATCGACTGGGAGGCATGGCGCCCACGCTGGGCCTTCAAC
TGGGACACCAAGGACATTTACCGGCAGCGCTCACGGGCACTGGTACAGGCACAGCACCCT
GATTGGCCAGCTCCTCAGGTGGAGGCAGTAGCCCAGGACCAGTTCCAGGGAGCTGCACGG
GCCTGGATGGCAGGCACCCTCCAGCTGGGGCGGGCACTGCGTCCTCGCGGCCTCTGGGGC
TTCTATGGCTTCCCTGACTGCTACAACTATGACTTTCTAAGCCCCAACTACACCGGCCAG
TGCCCATCAGGCATCCGTGCCCAAAATGACCAGCTAGGGTGGCTGTGGGGCCAGAGCCGT
GCCCTCTATCCCAGCATCTACATGCCCGCAGTGCTGGAGGGCACAGGGAAGTCACAGATG
TATGTGCAACACCGTGTGGCCGAGGCATTCCGTGTGGCTGTGGCTGCTGGTGACCCCAAT
CTGCCGGTGCTGCCCTATGTCCAGATCTTCTATGACACGACAAACCACTTTCTGCCCCTG
GATGAGCTGGAGCACAGCCTGGGGGAGAGTGCGGCCCAGGGGGCAGCTGGAGTGGTGCTC
TGGGTGAGCTGGGAAAATACAAGAACCAAGGAATCATGTCAGGCCATCAAGGAGTATATG
GACACTACACTGGGGCCCTTCATCCTGAACGTGACCAGTGGGGCCCTTCTCTGCAGTCAA
GCCCTGTGCTCCGGCCATGGCCGCTGTGTCCGCCGCACCAGCCACCCCAAAGCCCTCCTC
CTCCTTAACCCTGCCAGTTTCTCCATCCAGCTCACGCCTGGTGGTGGGCCCCTGAGCCTG
CGGGGTGCCCTCTCACTTGAAGATCAGGCACAGATGGCTGTGGAGTTCAAATGTCGATGC
TACCCTGGCTGGCAGGCACCGTGGTGTGAGCGGAAGAGCATGTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 435 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hyaluronidase-1
MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
YPGWQAPWCERKSMW
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q12794 |
| UniProtKB/Swiss-Prot Entry Name
| HYAL1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| U03056 |
| GeneCard ID
| HYAL1 |
| GenAtlas ID
| HYAL1 |
| HGNC ID
| HGNC:5320 |
| References |
|---|
| General References
| Not Available |