Cannabis Compound Database: Showing Protein Aminopeptidase O (CDBP04375)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04375

Secondary Accession Numbers

Not Available

Name

Aminopeptidase O

Description

Not Available

Synonyms

AP-O

Gene Name

AOPEP

Protein Type

Enzyme

Biological Properties

General Function

Involved in binding

Specific Function

Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart

GO Classification

Function
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
peptidase activity
Process
metabolic process
macromolecule metabolic process
cellular metabolic process
organic acid metabolic process
oxoacid metabolic process
carboxylic acid metabolic process
monocarboxylic acid metabolic process
fatty acid metabolic process
leukotriene biosynthetic process
protein metabolic process
proteolysis
unsaturated fatty acid metabolic process
icosanoid metabolic process
leukotriene metabolic process

Cellular Location

Cytoplasm (Potential)

Pathways

Not Available

Gene Properties

Chromosome Location

Not Available

Locus

Not Available

SNPs

AOPEP

Gene Sequence

>2460 bp
ATGGACATACAGCTGGACCCTGCCAGAGATGACCTGCCTCTCATGGCCAACACCAGCCAC
ATACTTGTGAAGCACTATGTACTGGATTTGGATGTGGATTTTGAAAGTCAAGTCATTGAG
GGGACCATAGTGCTTTTCCTCGAGGATGGAAACAGATTCAAGAAACAGAATAGCTCTATT
GAGGAAGCCTGCCAATCAGAATCAAACAAAGCCTGCAAATTTGGGATGCCTGAACCCTGC
CATATTCCCGTGACAAATGCAAGGACCTTCTCATCTGAAATGGAATATAATGATTTTGCA
ATCTGTAGTAAAGGTGAAAAAGATACTTCTGATAAAGATGGTAACCATGACAACCAGGAA
CATGCTTCTGGGATTTCTAGCTCAAAGTACTGCTGTGACACAGGGAATCATGGGAGTGAG
GATTTTTTGCTAGTGTTGGACTGCTGTGATTTATCTGTGTTAAAAGTCGAGGAGGTGGAT
GTTGCTGCTGTGCCAGGTCTGGAAAAATTTACAAGGTCTCCTGAGCTCACGGTTGTTTCT
GAGGAGTTCAGGAATCAGATTGTACGTGAACTTGTGACTTTGCCTGCAAATCGTTGGAGG
GAGCAGTTAGACTATTACGCTCGCTGCAGCCAGGCTCCTGGCTGTGGGGAACTCCTCTTT
GACACTGACACTTGGAGCTTGCAGATAAGGAAGACAGGGGCTCAGACAGCTACTGACTTT
CCTCATGCTATCAGGATATGGTACAAAACTAAACCTGAAGGGCGATCGGTTACATGGACC
TCAGACCAGAGTGGCAGGCCATGTGTTTATACTGTGGGATCTCCCATAAACAACAGGGCC
CTTTTTCCATGCCAGGAGCCACCCGTTGCCATGTCAACATGGCAGGCTACAGTTCGAGCA
GCTGCATCTTTTGTTGTTTTAATGAGTGGGGAAAATTCTGCCAAACCAACGCAGCTTTGG
GAAGAGTGCTCAAGCTGGTATTACTATGTAACTATGCCAATGCCAGCCTCCACCTTCACA
ATTGCAGTGGGATGCTGGACAGAAATGAAGATGGAGACATGGTCATCAAATGATTTGGCA
ACAGAGAGACCCTTCTCACCTTCTGAGGCCAACTTCAGGCATGTTGGTGTTTGCAGTCAC
ATGGAATACCCCTGCCGCTTCCAGAATGCTTCTGCCACCACCCAGGAGATCATTCCTCAT
CGGGTCTTTGCCCCTGTGTGCCTCACGGGTGCCTGCCAAGAGACCCTTCTGCGGCTGATC
CCTCCTTGCCTCTCAGCAGCACATTCTGTTCTGGGAGCACACCCGTTCTCTCGGCTGGAT
GTTCTCATCGTCCCTGCCAACTTTCCAAGTCTGGGGATGGCCAGCCCACACATCATGTTC
CTCTCTCAGAGCATCTTGACAGGAGGGAACCATCTCTGTGGGACCCGCCTCTGCCATGAA
ATTGCCCATGCCTGGTTTGGCCTAGCCATCGGGGCCCGAGACTGGACGGAGGAGTGGCTG
AGTGAAGGCTTCGCCACTCACTTGGAGGATGTGTTTTGGGCCACAGCACAGCAGCTGGCC
CCCTATGAGGCCCGGGAGCAGCAGGAGCTGAGGGCTTGTCTGCGCTGGCGTCGCCTCCAG
GACGAGATGCAATGCTCCCCCGAGGAGATGCAGGTGTTAAGACCCAGTAAAGACAAAACT
GGCCACACAAGTGACTCGGGAGCATCTGTTATCAAGCATGGACTTAATCCGGAGAAGATC
TTCATGCAGGTGCATTATTTAAAGGGCTACTTCCTTCTTCGGTTTCTTGCCAAAAGACTT
GGAGATGAAACCTATTTTTCATTTTTAAGAAAATTTGTGCACACATTTCATGGACAGCTG
ATTCTTTCCCAGGATTTCCTTCAAATGCTACTGGAGAACATTCCAGAAGAAAAAAGGCTT
GAGCTGTCTGTTGAAAACATCTACCAAGACTGGCTTGAGAGTTCCGGAATACCAAAGCCG
CTGCAGAGGGAGCGTCGCGCCGGGGCGGAGTGCGGGCTTGCGCGGCAAGTGCGCGCCGAG
GTCACGAAATGGATTGGAGTGAACCGGAGACCCCGAAAACGGAAGCGCAGGGAGAAGGAA
GAGGTGTTTGAAAAGCTTCTTCCAGACCAGCTGGTCTTGCTTCTGGAGCATCTCTTGGAG
CAGAAGACTCTGAGCCCCCGAACTCTGCAAAGCCTCCAGAGGACATACCACCTCCAGGAT
CAGGATGCAGAGGTTCGCCATCGGTGGTGTGAACTCATTGTTAAGCACAAGTTCACGAAA
GCCTACAAAAGTGTGGAGAGGTTCCTTCAGGAGGATCAGGCCATGGGTGTGTACCTCTAC
GGGGAGCTGATGGTGAGTGAGGACGCCAGACAGCAGCAGCTCGCCCGTAGGTGCTTCGAG
CGGACCAAGGAGCAGATGGATAGGTCCTCAGCCCAGGTGGTGGCCGAAATGTTATTTTAA

Protein Properties

Number of Residues

819

Molecular Weight

93571.6

Theoretical pI

6.13

Pfam Domain Function

Peptidase_M1 (PF01433 )
Leuk-A4-hydro_C (PF09127 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Aminopeptidase O
MDIQLDPARDDLPLMANTSHILVKHYVLDLDVDFESQVIEGTIVLFLEDGNRFKKQNSSI
EEACQSESNKACKFGMPEPCHIPVTNARTFSSEMEYNDFAICSKGEKDTSDKDGNHDNQE
HASGISSSKYCCDTGNHGSEDFLLVLDCCDLSVLKVEEVDVAAVPGLEKFTRSPELTVVS
EEFRNQIVRELVTLPANRWREQLDYYARCSQAPGCGELLFDTDTWSLQIRKTGAQTATDF
PHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATVRA
AASFVVLMSGENSAKPTQLWEECSSWYYYVTMPMPASTFTIAVGCWTEMKMETWSSNDLA
TERPFSPSEANFRHVGVCSHMEYPCRFQNASATTQEIIPHRVFAPVCLTGACQETLLRLI
PPCLSAAHSVLGAHPFSRLDVLIVPANFPSLGMASPHIMFLSQSILTGGNHLCGTRLCHE
IAHAWFGLAIGARDWTEEWLSEGFATHLEDVFWATAQQLAPYEAREQQELRACLRWRRLQ
DEMQCSPEEMQVLRPSKDKTGHTSDSGASVIKHGLNPEKIFMQVHYLKGYFLLRFLAKRL
GDETYFSFLRKFVHTFHGQLILSQDFLQMLLENIPEEKRLELSVENIYQDWLESSGIPKP
LQRERRAGAECGLARQVRAEVTKWIGVNRRPRKRKRREKEEVFEKLLPDQLVLLLEHLLE
QKTLSPRTLQSLQRTYHLQDQDAEVRHRWCELIVKHKFTKAYKSVERFLQEDQAMGVYLY
GELMVSEDARQQQLARRCFERTKEQMDRSSAQVVAEMLF

External Links

GenBank ID Protein

58737696

UniProtKB/Swiss-Prot ID

Q8N6M6

UniProtKB/Swiss-Prot Entry Name

AMPO_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AJ560639

GeneCard ID