Cannabis Compound Database: Showing Protein Beta-1,4 N-acetylgalactosaminyltransferase 2 (CDBP04365)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04365

Secondary Accession Numbers

Not Available

Name

Beta-1,4 N-acetylgalactosaminyltransferase 2

Description

Not Available

Synonyms

Sd(a) beta-1,4-GalNAc transferase
UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase

Gene Name

B4GALNT2

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring hexosyl groups

Specific Function

Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocytes, the colonic mucosa and other tissues. Transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain

GO Classification

Component
cell part
membrane part
intrinsic to membrane
intrinsic to organelle membrane
intrinsic to golgi membrane
integral to golgi membrane
Function
transferase activity, transferring glycosyl groups
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
Process
lipid modification
lipid glycosylation
metabolic process
primary metabolic process
lipid metabolic process
cellular lipid metabolic process

Cellular Location

Golgi apparatus membrane
Single-pass type II membrane protein (Potential)

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

17q21.32

SNPs

B4GALNT2

Gene Sequence

>1701 bp
ATGGGGAGCGCTGGCTTTTCCGTGGGAAAATTCCACGTGGAAGTGGCCTCTCGCGGCCGG
GAATGTGTCTCGGGGACGCCCGAGTGTGGGAATCGGCTCGGGAGTGCGGGCTTCGGGGCT
CTCTGCTTGGAACTCAGAGGCGCTGACCCAGCCTGGGGCCCGTTTGCTGCCCACGGGAGG
AGCCGCCGTCAGGGCTCGAGATTTCTGTGGCTCCTCAAGATATTGGTCATAATCCTGGTA
CTTGGCATTGTTGGATTTATGTTCGGAAGCATGTTCCTTCAAGCAGTGTTCAGCAGCCCC
AAGCCAGAACTCCCAAGTCCTGCCCCGGGTGTCCAGAAGCTGAAGCTTCTGCCTGAGGAA
CGTCTCAGGAACCTCTTTTCCTACGATGGAATCTGGCTGTTCCCGAAAAATCAGTGCAAA
TGTGAAGCCAACAAAGAGCAGGGAGGTTACAACTTTCAGGATGCCTATGGCCAGAGCGAC
CTCCCAGCGGTGAAAGCGAGGAGACAGGCTGAATTTGAACACTTTCAGAGGAGAGAAGGG
CTGCCCCGCCCACTGCCCCTGCTGGTCCAGCCCAACCTCCCCTTTGGGTACCCAGTCCAC
GGAGTGGAGGTGATGCCCCTGCACACGGTTCCCATCCCAGGCCTCCAGTTTGAAGGACCC
GATGCCCCCGTCTATGAGGTCACCCTGACAGCTTCTCTGGGGACACTGAACACCCTTGCT
GATGTCCCAGACAGTGTGGTGCAGGGCAGAGGCCAGAAGCAGCTGATCATTTCTACCAGT
GACCGGAAGCTGTTGAAGTTCATTCTTCAGCACGTGACATACACCAGCACGGGGTACCAG
CACCAGAAGGTAGACATAGTGAGTCTGGAGTCCAGGTCCTCAGTGGCCAAGTTTCCAGTG
ACCATCCGCCATCCTGTCATACCCAAGCTATACGACCCTGGACCAGAGAGGAAGCTCAGA
AACCTGGTTACCATTGCTACCAAGACTTTCCTCCGCCCCCACAAGCTCATGATCATGCTC
CGGAGTATTCGAGAGTATTACCCAGACTTGACCGTAATAGTGGCTGATGACAGCCAGAAG
CCCCTGGAAATTAAAGACAATCACGTGGAGTATTACACTATGCCCTTTGGGAAGGGTTGG
TTTGCTGGTAGGAACCTGGCCATATCTCAGGTCACCACCAAATACGTTCTCTGGGTGGAC
GATGATTTTCTCTTCAACGAGGAGACCAAGATTGAGGTGCTGGTGGATGTCCTGGAGAAA
ACAGAACTGGACGTGGTAGGCGGCAGTGTGCTGGGAAATGTGTTCCAGTTTAAGTTGTTG
CTGGAACAGAGTGAGAATGGGGCCTGCCTTCACAAGAGGATGGGATTTTTCCAACCCCTG
GATGGCTTCCCCAGCTGCGTGGTGACCAGTGGCGTGGTCAACTTCTTCCTGGCCCACACG
GAGCGACTCCAAAGAGTTGGCTTTGATCCCCGCCTGCAACGAGTGGCTCACTCAGAATTC
TTCATTGATGGGCTAGGGACCCTACTCGTGGGGTCATGCCCAGAAGTGATTATAGGTCAC
CAGTCTCGGTCTCCAGTGGTGGACTCAGAACTGGCTGCCCTAGAGAAGACCTACAATACA
TACCGGTCCAACACCCTCACCCGGGTCCAGTTCAAGCTGGCCCTCCACTACTTCAAGAAC
CATCTCCAATGTGCCGCATAA

Protein Properties

Number of Residues

566

Molecular Weight

63257.6

Theoretical pI

8.72

Pfam Domain Function

Glycos_transf_2 (PF00535 )

Signals

["None"]

Transmembrane Regions

["68-88"]

Protein Sequence

>Beta-1,4 N-acetylgalactosaminyltransferase 2
MGSAGFSVGKFHVEVASRGRECVSGTPECGNRLGSAGFGALCLELRGADPAWGPFAAHGR
SRRQGSRFLWLLKILVIILVLGIVGFMFGSMFLQAVFSSPKPELPSPAPGVQKLKLLPEE
RLRNLFSYDGIWLFPKNQCKCEANKEQGGYNFQDAYGQSDLPAVKARRQAEFEHFQRREG
LPRPLPLLVQPNLPFGYPVHGVEVMPLHTVPIPGLQFEGPDAPVYEVTLTASLGTLNTLA
DVPDSVVQGRGQKQLIISTSDRKLLKFILQHVTYTSTGYQHQKVDIVSLESRSSVAKFPV
TIRHPVIPKLYDPGPERKLRNLVTIATKTFLRPHKLMIMLRSIREYYPDLTVIVADDSQK
PLEIKDNHVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFNEETKIEVLVDVLEK
TELDVVGGSVLGNVFQFKLLLEQSENGACLHKRMGFFQPLDGFPSCVVTSGVVNFFLAHT
ERLQRVGFDPRLQRVAHSEFFIDGLGTLLVGSCPEVIIGHQSRSPVVDSELAALEKTYNT
YRSNTLTRVQFKLALHYFKNHLQCAA

External Links

GenBank ID Protein

227497754

UniProtKB/Swiss-Prot ID

Q8NHY0

UniProtKB/Swiss-Prot Entry Name

B4GN2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_153446.2

GeneCard ID