4340 CDBP04339 Polyprenol reductase Q9H8P0 PORED_HUMAN true false Enzyme Homo_sapiens SRD5A3 318 36521.005 9.391 Involved in oxidoreductase activity, acting on the CH-CH group of donors Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). NM_024592.3 13375785 SRD5A3 4 4q12 SRD5A3 HGNC:25812 true hsa:79644 HS13249-MONOMER NP_078868.1:NM_024592.4 Overexpressed in hormone-refractory prostate cancers (HRPC). Almost no or little expression in normal adult organs. 2020-06-12T23:07:24Z 2020-06-12T23:07:24Z 0 0 0