Cannabis Compound Database: Showing Protein Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (CDBP04337)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP04337

Secondary Accession Numbers

Not Available

Name

Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Description

Not Available

Synonyms

Alpha-2-glucosyltransferase ALG10-B
Asparagine-linked glycosylation protein 10 homolog B
Potassium channel regulator 1
Alpha-1,2-glucosyltransferase ALG10-A

Gene Name

ALG10B

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring hexosyl groups

Specific Function

Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2.

GO Classification

Biological Process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation via asparagine
Cellular Component
plasma membrane
integral to membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
catalytic activity
transferase activity
transferase activity, transferring hexosyl groups
transferase activity, transferring glycosyl groups
Molecular Function
transferase activity, transferring hexosyl groups

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
N-Glycan biosynthesis	Not Available
Muscle/Heart Contraction		Not Available
Acebutolol Action Pathway		Not Available
Alprenolol Action Pathway		Not Available

Gene Properties

Chromosome Location

Locus

12q12

SNPs

ALG10B

Gene Sequence

>1422 bp
ATGGCGCAGCTAGAGGGTTACTGTTTCTCGGCCGCCTTGAGCTGTACCTTTTTAGTGTCC
TGCCTCCTCTTCTCCGCCTTCAGCCGGGCGCTGCGAGAGCCCTACATGGACGAGATCTTC
CACCTGCCTCAGGCGCAGCGCTACTGTGAGGGCCATTTCTCCCTTTCCCAGTGGGATCCC
ATGATTACTACATTACCTGGCTTGTACCTGGTGTCAGTTGGAGTGGTCAAACCTGCCATT
TGGATCTTTGGATGGTCTGAACATGTTGTCTGCTCCATTGGGATGCTCAGATTTGTTAAT
CTTCTCTTCAGTGTTGGCAACTTCTATTTACTATATTTGCTTTTCCACAAGGTACAACCC
AGAAACAAGGCTGCCTCAAGTATCCAGAGAGTCTTGTCAACATTAACACTAGCAGTATTT
CCAACACTTTATTTTTTTAACTTCCTTTATTATACAGAAGCAGGATCTATGTTTTTTACT
CTTTTTGCATATTTGATGTGTCTTTATGGAAATCATAAAACTTCAGCCTTCCTTGGATTT
TGTGGCTTCATGTTTCGGCAAACAAATATCATCTGGGCTGTCTTCTGTGCAGGGAATGTC
ATTGCACAAAAGTTAACTGAGGCTTGGAAAACTGAGCTACAAAAGAAGGAAGACAGACTT
CCACCTATTAAAGGACCATTTGCAGAATTCAGAAAAATTCTTCAGTTTCTTTTGGCTTAT
TCCATGTCCTTTAAAAACTTGAGTATGCTTTTCTGTTTGACTTGGCCCTACATCCTTCTG
GGATTTCTGTTTTGTGCTTTTGTAGTAGTTAATGGTGGAATTGTTATTGGCGATCGGAGT
AGTCATGAAGCCTGTCTTCATTTTCCTCAACTATTCTACTTTTTTTCATTTACTCTCTTT
TTTTCTTTTCCTCATCTCCTGTCTCCTAGCAAAATTAAGACTTTTCTTTCCTTAGTTTGG
AAACATGGAATTCTGTTTTTGGTGGTTACCTTAGTCTCTGTGTTTTTAGTTTGGAAATTC
ACTTATGCTCATAAATACTTGCTAGCAGACAATAGACATTATACTTTCTATGTGTGGAAA
AGAGTTTTTCAAAGATATGCAATTCTGAAATATTTGTTAGTTCCAGCCTATATATTTGCT
GGTTGGAGTATAGCTGACTCATTGAAATCAAAGCCAATTTTTTGGAATTTAATGTTTTTC
ATATGCTTGTTCATTGTTATAGTTCCTCAGAAACTGCTGGAATTTCGTTACTTCATTTTA
CCTTATGTCATTTATAGGCTTAACATAACTCTGCCTCCCACATCCAGACTTGTTTGTGAA
CTGAGTTGCTATGCAATTGTTAATTTCATAACTTTTTACATCTTTCTGAACAAGACTTTT
CAGTGGCCAAATAGTCAGGACATTCAAAGGTTTATGTGGTAA

Protein Properties

Number of Residues

473

Molecular Weight

55433.33

Theoretical pI

9.19

Pfam Domain Function

DIE2_ALG10 (PF04922 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Putative alpha-1,2-glucosyltransferase ALG10-B
MAQLEGYCFSAALSCTFLVSCLLFSAFSRALREPYMDEIFHLPQAQRYCEGHFSLSQWDP
MITTLPGLYLVSVGVVKPAIWIFAWSEHVVCSIGMLRFVNLLFSVGNFYLLYLLFHKVQP
RNKAASSIQRVLSTLTLAVFPTLYFFNFLYYTEAGSMFFTLFAYLMCLYGNHKTSAFLGF
CGFMFRQTNIIWAVFCAGNVIAQKLTEAWKTELQKKEDRLPPIKGPFAEFRKILQFLLAY
SMSFKNLSMLFCLTWPYILLGFLFCAFVVVNGGIVIGDRSSHEACLHFPQLFYFFSFTLF
FSFPHLLSPSKIKTFLSLVWKHGILFLVVTLVSVFLVWKFTYAHKYLLADNRHYTFYVWK
RVFQRYAILKYLLVPAYIFAGWSIADSLKSKPIFWNLMFFICLFIVIVPQKLLEFRYFIL
PYVIYRLNITLPPTSRLVCELSCYAIVNFITFYIFLNKTFQWPNSQDIQRFMW

External Links

GenBank ID Protein

61966697

UniProtKB/Swiss-Prot ID

Q5I7T1

UniProtKB/Swiss-Prot Entry Name

AG10B_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001013620.3

GeneCard ID