| Identification |
|---|
| HMDB Protein ID
| CDBP04332 |
| Secondary Accession Numbers
| Not Available |
| Name
| A-kinase anchor protein 10, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- AKAP-10
- D-AKAP-2
- Dual specificity A kinase-anchoring protein 2
- PRKA10
- Protein kinase A-anchoring protein 10
|
| Gene Name
| AKAP10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in signal transducer activity |
| Specific Function
| Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase |
| GO Classification
|
| Function |
| molecular transducer activity |
| signal transducer activity |
|
| Cellular Location
|
- Cytoplasm
- Mitochondrion
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17p11.1 |
| SNPs
| AKAP10 |
| Gene Sequence
|
>1989 bp
ATGAGGGGAGCCGGGCCCTCCCCGCGCCAGTCCCCCCGCACCCTCCGTCCCGACCCGGGC
CCCGCCATGTCCTTCTTCCGGCGGAAAGTGAAAGGCAAAGAACAAGAGAAGACCTCAGAT
GTGAAGTCCATTAAAGCTTCAATATCCGTACATTCCCCACAAAAAAGCACTAAAAATCAT
GCCTTGCTGGAGGCTGCAGGACCAAGTCATGTTGCAATCAATGCCATTTCTGCCAACATG
GACTCCTTTTCAAGTAGCAGGACAGCCACACTTAAGAAGCAGCCAAGCCACATGGAGGCT
GCTCATTTTGGTGACCTGGGCAGATCTTGTCTGGACTACCAGACTCAAGAGACCAAATCA
AGCCTTTCTAAGACCCTTGAACAAGTCTTGCACGACACTATTGTCCTCCCTTACTTCATT
CAATTCATGGAACTTCGGCGAATGGAGCATTTGGTGAAATTTTGGTTAGAGGCTGAAAGT
TTTCATTCAACAACTTGGTCGCGAATAAGAGCACACAGTCTAAACACAATGAAGCAGAGC
TCACTGGCTGAGCCTGTCTCTCCATCTAAAAAGCATGAAACTACAGCGTCTTTTTTAACT
GATTCTCTTGATAAGAGATTGGAGGATTCTGGCTCAGCACAGTTGTTTATGACTCATTCA
GAAGGAATTGACCTGAATAATAGAACTAACAGCACTCAGAATCACTTGCTGCTTTCCCAG
GAATGTGACAGTGCCCATTCTCTCCGTCTTGAAATGGCCAGAGCAGGAACTCACCAAGTT
TCCATGGAAACCCAAGAATCTTCCTCTACACTTACAGTAGCCAGTAGAAATAGTCCCGCT
TCTCCACTAAAAGAATTGTCAGGAAAACTAATGAAAAGTATAGAACAAGATGCAGTGAAT
ACTTTTACCAAATATATATCTCCAGATGCTGCTAAACCAATACCAATTACAGAAGCAATG
AGAAATGACATCATAGCAAGGATTTGTGGAGAAGATGGACAGGTGGATCCCAACTGTTTC
GTTTTGGCACAGTCCATAGTCTTTAGTGCAATGGAGCAAGAGCACTTTAGTGAGTTTCTG
CGAAGTCACCATTTCTGTAAATACCAGATTGAAGTGCTGACCAGTGGAACTGTTTACCTG
GCTGACATTCTCTTCTGTGAGTCAGCCCTCTTTTATTTCTCTGAGTACATGGAAAAAGAG
GATGCAGTGAATATCTTACAATTCTGGTTGGCAGCAGATAACTTCCAGTCTCAGCTTGCT
GCCAAAAAGGGGCAATATGATGGACAGGAGGCACAGAATGATGCCATGATTTTATATGAC
AAGTACTTCTCCCTCCAAGCCACACATCCTCTTGGATTTGATGATGTTGTACGATTAGAA
ATTGAATCCAATATCTGCAGGGAAGGTGGGCCACTCCCCAACTGTTTCACAACTCCATTA
CGTCAGGCCTGGACAACCATGGAGAAGGTCTTTTTGCCTGGCTTTCTGTCCAGCAATCTT
TATTATAAATATTTGAATGATCTCATCCATTCGGTTCGAGGAGATGAATTTCTGGGCGGG
AACGTGTCGCCGACTGCTCCTGGCTCTGTTGGCCCTCCTGATGAGTCTCACCCAGGGAGT
TCTGACAGCTCTGCGTCTCAGTCCAGTGTGAAAAAAGCCAGTATTAAAATACTGAAAAAT
TTTGATGAAGCGATAATTGTGGATGCGGCAAGTCTGGATCCAGAATCTTTATATCAACGG
ACATATGCCGGGAAGATGACATTTGGAAGAGTGAGTGACTTGGGGCAATTCATCCGGGAA
TCTGAGCCTGAACCTGATGTAAGGAAATCAAAAGGATCCATGTTCTCACAAGCTATGAAG
AAATGGGTGCAAGGAAATACTGATGAGGCCCAGGAAGAGCTAGCTTGGAAGATTGCTAAA
ATGATAGTCAGTGACATTATGCAGCAGGCTCAGTATGATCAACCGTTAGAGAAATCTACA
AAGTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 662 |
| Molecular Weight
| 73817.5 |
| Theoretical pI
| 6.35 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>A-kinase anchor protein 10, mitochondrial
MRGAGPSPRQSPRTLRPDPGPAMSFFRRKVKGKEQEKTSDVKSIKASISVHSPQKSTKNH
ALLEAAGPSHVAINAISANMDSFSSSRTATLKKQPSHMEAAHFGDLGRSCLDYQTQETKS
SLSKTLEQVLHDTIVLPYFIQFMELRRMEHLVKFWLEAESFHSTTWSRIRAHSLNTVKQS
SLAEPVSPSKKHETTASFLTDSLDKRLEDSGSAQLFMTHSEGIDLNNRTNSTQNHLLLSQ
ECDSAHSLRLEMARAGTHQVSMETQESSSTLTVASRNSPASPLKELSGKLMKSIEQDAVN
TFTKYISPDAAKPIPITEAMRNDIIARICGEDGQVDPNCFVLAQSIVFSAMEQEHFSEFL
RSHHFCKYQIEVLTSGTVYLADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLA
AKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPLPNCFTTPL
RQAWTTMEKVFLPGFLSSNLYYKYLNDLIHSVRGDEFLGGNVSLTAPGSVGPPDESHPGS
SDSSASQSSVKKASIKILKNFDEAIIVDAASLDPESLYQRTYAGKMTFGRVSDLGQFIRE
SEPEPDVRKSKGSMFSQAMKKWVQGNTDEAQEELAWKIAKMIVSDIMQQAQYDQPLEKST
KL
|
| External Links |
|---|
| GenBank ID Protein
| 2707344 |
| UniProtKB/Swiss-Prot ID
| O43572 |
| UniProtKB/Swiss-Prot Entry Name
| AKA10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF037439 |
| GeneCard ID
| AKAP10 |
| GenAtlas ID
| AKAP10 |
| HGNC ID
| HGNC:368 |
| References |
|---|
| General References
| Not Available |