Cannabis Compound Database: Showing Protein Queuine tRNA-ribosyltransferase subunit QTRTD1 (CDBP04325)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04325

Secondary Accession Numbers

Not Available

Name

Queuine tRNA-ribosyltransferase subunit QTRTD1

Description

Not Available

Synonyms

Queuine tRNA-ribosyltransferase domain-containing protein 1

Gene Name

QTRTD1

Protein Type

Enzyme

Biological Properties

General Function

Involved in queuine tRNA-ribosyltransferase activity

Specific Function

Interacts with QTRT1 to form an active queuine tRNA-ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity).

GO Classification

Biological Process
queuosine biosynthetic process
Cellular Component
mitochondrion
Function
catalytic activity
transferase activity
transferase activity, transferring pentosyl groups
transferase activity, transferring glycosyl groups
queuine trna-ribosyltransferase activity
Molecular Function
metal ion binding
queuine tRNA-ribosyltransferase activity
Process
ncrna metabolic process
trna metabolic process
trna processing
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
trna modification
queuosine biosynthetic process
rna metabolic process

Cellular Location

Cytoplasm
Mitochondrion

Pathways

Name	SMPDB/Pathwhiz	KEGG
tRNA-queuosine biosynthesis	Not Available	Not Available

Gene Properties

Chromosome Location

Locus

3q13.31

SNPs

QTRTD1

Gene Sequence

>1248 bp
ATGAAGCTGAGTCTTACCAAGGTAGTTAATGGCTGTCGCCTAGGAAAAATAAAAAACCTG
GGCAAAACAGGGGACCACACCATGGATATTCCAGGCTGCCTTCTGTATACCAAGACTGGC
TCCGCCCCACACCTCACCCATCACACGCTGCATAATATCCACGGGGTTCCTGCCATGGCT
CAGCTTACGCTGTCATCCCTAGCAGAACATCATGAAGTCTTGACAGAATATAAAGAAGGA
GTTGGAAAGTTTATAGGCATGCCAGAATCACTCTTGTACTGCTCCCTGCACGATCCAGTC
AGCCCCTGCCCGGCTGGTTATGTAACAAACAAGTCTGTGTCTGTGTGGAGTGTTGCAGGA
CGAGTGGAAATGACTGTTTCCAAGTTCATGGCAATTCAGAAGGCCCTTCAGCCAGACTGG
TTCCAGTGCCTCTCCGATGGAGAAGTATCTTGTAAGGAAGCAACTTCCATAAAAAGGGTC
AGAAAGTCTGTTGACCGATCACTTCTTTTCTTGGATAACTGTCTGCGGCTGCAGGAAGAG
TCAGAGGTTCTTCAGAAGAGTGTGATCATTGGAGTGATTGAAGGTGGAGATGTGATGGAA
GAGAGGCTGAGGTCAGCACGAGAGACAGCCAAGCGGCCTGTGGGTGGCTTCCTTCTGGAT
GGTTTTCAAGGAAATCCAACAACCCTGGAGGCTAGACTACGCTTGCTGTCATCAGTCACT
GCAGAGCTGCCGGAGGACAAGCCAAGGCTCATATCTGGTGTTAGTCGGCCAGATGAGGTG
CTCGAGTGTATTGAAAGAGGAGTGGACTTATTTGAGAGTTTTTTCCCTTATCAAGTAACA
GAGCGGGGATGTGCCCTGACTTTCAGTTTTGATTACCAGCCGAATCCTGAAGAGACACTA
CTACAACAAAATGGAACACAAGAAGAAATAAAATGTATGGATCAAATAAAGAAAATTGAA
ACAACTGGTTGCAACCAAGAAATAACATCATTTGAAATTAATCTGAAGGAAAAAAAGTAC
CAGGAGGACTTTAACCCGCTGGTGAGAGGATGTTCCTGTTACTGCTGTAAGAATCACACT
CGGGCATACATCCACCATCTGCTGGTGACCAATGAGCTGCTGGCCGGAGTCCTGCTTATG
ATGCACAACTTTGAACACTACTTTGGGTTTTTCCATTACATCCGGGAAGCACTAAAAAGT
GACAAACTGGCACAGTTGAAAGAGCTCATCCACAGGCAAGCATCTTGA

Protein Properties

Number of Residues

415

Molecular Weight

48203.07

Theoretical pI

6.617

Pfam Domain Function

TGT (PF01702 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Queuine tRNA-ribosyltransferase subunit QTRTD1
MKLSLTKVVNGCRLGKIKNLGKTGDHTMDIPGCLLYTKTGSAPHLTHHTLHNIHGVPAMA
QLTLSSLAEHHEVLTEYKEGVGKFIGMPESLLYCSLHDPVSPCPAGYVTNKSVSVWSVAG
RVEMTVSKFMAIQKALQPDWFQCLSDGEVSCKEATSIKRVRKSVDRSLLFLDNCLRLQEE
SEVLQKSVIIGVIEGGDVMEERLRSARETAKRPVGGFLLDGFQGNPTTLEARLRLLSSVT
AELPEDKPRLISGVSRPDEVLECIERGVDLFESFFPYQVTERGCALTFSFDYQPNPEETL
LQQNGTQEEIKCMDQIKKIETTGCNQEITSFEINLKEKKYQEDFNPLVRGCSCYCCKNHT
RAYIHHLLVTNELLAGVLLMMHNFEHYFGFFHYIREALKSDKLAQLKELIHRQAS

External Links

GenBank ID Protein

13375872

UniProtKB/Swiss-Prot ID

Q9H974

UniProtKB/Swiss-Prot Entry Name

QTRD1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_024638.2

GeneCard ID