Identification |
HMDB Protein ID
| CDBP04316 |
Secondary Accession Numbers
| Not Available |
Name
| Serine/threonine-protein phosphatase PGAM5, mitochondrial |
Description
| Not Available |
Synonyms
|
- Bcl-XL-binding protein v68
- Phosphoglycerate mutase family member 5
|
Gene Name
| PGAM5 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in phosphoprotein phosphatase activity |
Specific Function
| Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
|
GO Classification
|
Cellular Component |
mitochondrial outer membrane |
integral to membrane |
Molecular Function |
phosphoprotein phosphatase activity |
|
Cellular Location
|
- Mitochondrion
- Membrane
- Mitochondrion outer membrane
- Single-pass membrane protein (Potential)
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 12 |
Locus
| 12q24.33 |
SNPs
| PGAM5 |
Gene Sequence
|
>870 bp
ATGGCGTTCCGGCAGGCGCTGCAGCTGGCGGCCTGCGGGCTGGCCGGGGGCTCGGCCGCC
GTGCTCTTCTCGGCCGTGGCGGTAGGGAAGCCGCGCGCAGGCGGGGACGCGGAGCCACGC
CCGGCTGAGCCGCCGGCCTGGGCGGGGGGCGCGCGGCCGGGCCCCGGTGTCTGGGACCCC
AACTGGGACAGGCGAGAACCACTGTCTCTGATCAACGTGCGGAAGAGGAACGTGGAATCT
GGGGAAGAAGAGCTGGCGTCCAAGCTGGACCACTACAAAGCCAAGGCCACGCGGCACATC
TTCCTCATCAGGCATTCCCAGTACCACGTGGATGGCTCCCTGGAGAAGGACCGCACTCTG
ACCCCGCTGGGTCGGGAGCAGGCTGAACTCACTGGGCTCCGCCTGGCAAGCTTGGGGTTG
AAGTTTAATAAAATCGTCCATTCGTCTATGACGCGCGCCATAGAGACCACCGATATCATC
AGCCGGCACCTGCCAGGCGTCTGCAAAGTCAGCACAGATCTGCTGCGGGAAGGCGCCCCC
ATCGAGCCAGACCCGCCCGTGTCTCATTGGAAGCCGGAAGCTGTGCAGTATTACGAAGAC
GGAGCCCGGATCGAGGCCGCCTTCCGGAACTACATCCACCGCGCAGATGCCAGGCAGGAG
GAGGACAGTTACGAGATCTTCATCTGTCACGCCAACGTCATCCGCTACATCGTGTGCAGA
GCACTGCAGTTTCCTCCTGAAGGCTGGCTCCGGCTCTCCCTCAATAATGGCAGCATCACC
CACCTGGTGATCCGACCCAACGGCCGAGTTGCGCTCAGGACCCTCGGGGACACGGGGTTC
ATGCCTCCCGACAAGATCACTCGATCCTGA
|
Protein Properties |
Number of Residues
| 289 |
Molecular Weight
| 32004.11 |
Theoretical pI
| 8.679 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Serine/threonine-protein phosphatase PGAM5, mitochondrial
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDP
NWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTL
TPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAP
IEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCR
ALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
|
External Links |
GenBank ID Protein
| 281604136 |
UniProtKB/Swiss-Prot ID
| Q96HS1 |
UniProtKB/Swiss-Prot Entry Name
| PGAM5_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_001170543.1 |
GeneCard ID
| PGAM5 |
GenAtlas ID
| PGAM5 |
HGNC ID
| HGNC:28763 |
References |
General References
| Not Available |