Identification
HMDB Protein ID CDBP04316
Secondary Accession Numbers Not Available
Name Serine/threonine-protein phosphatase PGAM5, mitochondrial
Description Not Available
Synonyms
  1. Bcl-XL-binding protein v68
  2. Phosphoglycerate mutase family member 5
Gene Name PGAM5
Protein Type Enzyme
Biological Properties
General Function Involved in phosphoprotein phosphatase activity
Specific Function Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
GO Classification
Cellular Component
mitochondrial outer membrane
integral to membrane
Molecular Function
phosphoprotein phosphatase activity
Cellular Location
  1. Mitochondrion
  2. Membrane
  3. Mitochondrion outer membrane
  4. Single-pass membrane protein (Potential)
Pathways
Gene Properties
Chromosome Location 12
Locus 12q24.33
SNPs PGAM5
Gene Sequence
>870 bp
ATGGCGTTCCGGCAGGCGCTGCAGCTGGCGGCCTGCGGGCTGGCCGGGGGCTCGGCCGCC
GTGCTCTTCTCGGCCGTGGCGGTAGGGAAGCCGCGCGCAGGCGGGGACGCGGAGCCACGC
CCGGCTGAGCCGCCGGCCTGGGCGGGGGGCGCGCGGCCGGGCCCCGGTGTCTGGGACCCC
AACTGGGACAGGCGAGAACCACTGTCTCTGATCAACGTGCGGAAGAGGAACGTGGAATCT
GGGGAAGAAGAGCTGGCGTCCAAGCTGGACCACTACAAAGCCAAGGCCACGCGGCACATC
TTCCTCATCAGGCATTCCCAGTACCACGTGGATGGCTCCCTGGAGAAGGACCGCACTCTG
ACCCCGCTGGGTCGGGAGCAGGCTGAACTCACTGGGCTCCGCCTGGCAAGCTTGGGGTTG
AAGTTTAATAAAATCGTCCATTCGTCTATGACGCGCGCCATAGAGACCACCGATATCATC
AGCCGGCACCTGCCAGGCGTCTGCAAAGTCAGCACAGATCTGCTGCGGGAAGGCGCCCCC
ATCGAGCCAGACCCGCCCGTGTCTCATTGGAAGCCGGAAGCTGTGCAGTATTACGAAGAC
GGAGCCCGGATCGAGGCCGCCTTCCGGAACTACATCCACCGCGCAGATGCCAGGCAGGAG
GAGGACAGTTACGAGATCTTCATCTGTCACGCCAACGTCATCCGCTACATCGTGTGCAGA
GCACTGCAGTTTCCTCCTGAAGGCTGGCTCCGGCTCTCCCTCAATAATGGCAGCATCACC
CACCTGGTGATCCGACCCAACGGCCGAGTTGCGCTCAGGACCCTCGGGGACACGGGGTTC
ATGCCTCCCGACAAGATCACTCGATCCTGA
Protein Properties
Number of Residues 289
Molecular Weight 32004.11
Theoretical pI 8.679
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Serine/threonine-protein phosphatase PGAM5, mitochondrial
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDP
NWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTL
TPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAP
IEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCR
ALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
GenBank ID Protein 281604136
UniProtKB/Swiss-Prot ID Q96HS1
UniProtKB/Swiss-Prot Entry Name PGAM5_HUMAN
PDB IDs
GenBank Gene ID NM_001170543.1
GeneCard ID PGAM5
GenAtlas ID PGAM5
HGNC ID HGNC:28763
References
General References Not Available