| Identification |
|---|
| HMDB Protein ID
| CDBP04279 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium channel protein type 7 subunit alpha |
| Description
| Not Available |
| Synonyms
|
- Putative voltage-gated sodium channel subunit alpha Nax
- Sodium channel protein cardiac and skeletal muscle subunit alpha
- Sodium channel protein type VII subunit alpha
|
| Gene Name
| SCN7A |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient |
| GO Classification
|
| Component |
| membrane |
| cell part |
| ion channel complex |
| cation channel complex |
| macromolecular complex |
| protein complex |
| sodium channel complex |
| voltage-gated sodium channel complex |
| Function |
| voltage-gated sodium channel activity |
| cation channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| sodium channel activity |
| transporter activity |
| ion channel activity |
| Process |
| sodium ion transport |
| establishment of localization |
| transport |
| transmembrane transport |
| monovalent inorganic cation transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q21-q23 |
| SNPs
| SCN7A |
| Gene Sequence
|
>5049 bp
ATGTTGGCTTCACCAGAACCTAAGGGCCTTGTTCCCTTCACTAAAGAGTCTTTTGAACTT
ATAAAACAGCATATTGCTAAAACACATAATGAAGACCATGAAGAAGAAGACTTAAAGCCA
ACTCCTGATTTGGAAGTTGGCAAAAAGCTTCCATTTATTTATGGAAACCTTTCTCAAGGA
ATGGTGTCAGAGCCCTTGGAAGATGTGGACCCATATTACTACAAGAAAAAAAATACTTTC
ATAGTATTAAATAAAAATAGAACAATCTTCAGATTCAATGCGGCTTCCATCTTGTGTACA
TTGTCTCCTTTCAATTGTATTAGAAGAACAACTATCAAGGTTTTGGTACATCCCTTTTTC
CAACTGTTTATTCTAATTAGTGTCCTGATTGATTGCGTATTCATGTCCCTGACTAATTTG
CCAAAATGGAGACCAGTATTAGAGAATACTTTGCTTGGAATTTACACATTTGAAATACTT
GTAAAACTCTTTGCAAGAGGTGTCTGGGCAGGATCATTTTCCTTCCTCGGTGATCCATGG
AACTGGCTCGATTTCAGCGTAACTGTGTTTGAGGTTATTATAAGATACTCACCTCTGGAC
TTCATTCCAACGCTTCAAACTGCAAGAACTTTGAGAATTTTAAAAATTATTCCTTTAAAT
CAAGGTCTGAAATCCCTTGTAGGGGTCCTGATCCACTGCTTGAAGCAGCTTATTGGTGTC
ATTATCCTAACTCTGTTTTTTCTGAGCATATTTTCTCTAATTGGGATGGGGCTCTTCATG
GGCAACTTGAAACATAAATGTTTTCGATGGCCCCAAGAGAATGAAAATGAAACCCTGCAC
AACAGAACTGGAAACCCATATTATATTCGAGAAACAGAAAACTTTTATTATTTGGAAGGA
GAAAGATATGCTCTCCTTTGTGGCAACAGGACAGATGCTGGTCAGTGTCCTGAAGGATAT
GTGTGTGTAAAAGCTGGCATAAATCCTGATCAAGGCTTCACAAATTTTGACAGTTTTGGC
TGGGCCTTATTTGCCCTATTTCGGTTAATGGCTCAGGATTACCCTGAAGTACTTTATCAC
CAGATACTTTATGCTTCTGGGAAGGTCTACATGATATTTTTTGTGGTGGTAAGTTTTTTG
TTTTCCTTTTATATGGCAAGTTTGTTCTTAGGCATACTTGCCATGGCCTATGAAGAAGAA
AAGCAGAGAGTTGGTGAAATATCTAAGAAGATTGAACCAAAATTTCAACAGACTGGAAAA
GAACTTCAAGAAGGAAATGAAACAGATGAGGCCAAGACCATACAAATAGAAATGAAGAAA
AGGTCACCAATTTCCACAGACACATCATTGGATGTGTTGGAAGATGCTACTCTCAGACAT
AAGGAAGAACTTGAAAAATCCAAGAAGATATGCCCATTATACTGGTATAAGTTTGCTAAA
ACTTTCTTGATCTGGAATTGTTCTCCCTGTTGGTTAAAATTGAAAGAGTTTGTCCATAGG
ATTATAATGGCACCATTTACTGATCTTTTCCTTATCATATGCATAATTTTAAACGTATGT
TTTCTGACCTTGGAGCATTATCCAATGAGTAAACAAACTAACACTCTTCTCAACATTGGA
AACCTGGTTTTCATTGGAATTTTCACAGCAGAAATGATTTTTAAAATAATTGCAATGCAT
CCATATGGGTATTTCCAAGTAGGTTGGAACATTTTTGATAGCATGATAGTGTTCCATGGT
TTAATAGAACTTTGTCTAGCAAATGTTGCAGGAATGGCTCTTCTTCGATTATTCAGGATG
TTAAGAATTTTCAAGTTGGGAAAGTATTGGCCAACATTCCAGATTTTGATGTGGTCTCTT
AGTAACTCATGGGTGGCCCTGAAAGACTTGGTCCTGTTGTTGTTCACATTCATCTTCTTT
TCTGCTGCATTCGGCATGAAGCTGTTTGGTAAGAATTATGAAGAATTTGTCTGCCACATA
GACAAAGACTGTCAACTCCCACGCTGGCACATGCATGACTTTTTCCACTCCTTCCTGAAT
GTGTTCCGAATTCTCTGTGGAGAGTGGGTAGAGACCTTGTGGGACTGTATGGAGGTTGCA
GGCCAATCCTGGTGTATTCCTTTTTACCTGATGGTCATTTTAATTGGAAATTTACTGGTA
CTTTACCTGTTTCTGGCATTGGTGAGCTCATTTAGTTCATGCAAGGATGTAACAGCTGAA
GAGAATAATGAAGCAAAAAATCTCCAGCTTGCAGTGGCAAGAATTAAAAAAGGAATAAAC
TATGTGCTTCTTAAAATACTATGCAAAACACAAAATGTCCCAAAGGACACAATGGACCAT
GTAAATGAGGTATATGTTAAAGAAGATATTTCTGACCATACCCTTTCTGAATTGAGCAAC
ACCCAAGATTTTCTCAAAGATAAGGAAAAAAGCAGTGGCACAGAGAAAAACGCTACTGAA
AATGAGAGCCAATCACTTATCCCCAGTCCTAGTGTCTCAGAAACTGTACCAATTGCTTCA
GGAGAATCTGATATAGAAAATCTGGATAATAAGGAGATTCAGAGTAAGTCTGGTGATGGA
GGCAGCAAAGAGAAAATAAAGCAATCTAGCTCATCTGAATGCAGTACTGTTGATATTGCT
ATCTCTGAAGAAGAAGAAATGTTCTATGGAGGTGAAAGATCAAAGCATCTGAAAAATGGT
TGCAGACGCGGATCTTCACTTGGTCAAATCAGTGGAGCATCCAAGAAAGGAAAAATCTGG
CAGAACATCAGGAAAACCTGCTGCAAGATTGTAGAGAACAATTGGTTTAAGTGTTTTATT
GGGCTTGTTACTCTGCTCAGCACTGGCACTCTGGCTTTTGAAGATATATATATGGATCAG
AGAAAGACAATTAAAATTTTATTAGAATATGCTGACATGATCTTTACTTATATCTTCATT
CTGGAAATGCTTCTAAAATGGATGGCATATGGTTTTAAGGCCTATTTCTCTAATGGCTGG
TACAGGCTGGACTTCGTGGTTGTTATTGTGTTTTGTCTTAGCTTAATAGGCAAAACTCGG
GAAGAACTAAAACCTCTTATTTCCATGAAATTCCTTCGGCCCCTCAGAGTTCTATCTCAA
TTTGAAAGAATGAAGGTGGTTGTGAGAGCTTTGATCAAAACAACCTTACCCACTTTGAAT
GTGTTTCTTGTCTGCCTGATGATCTGGCTGATTTTTAGTATCATGGGAGTAGACTTATTT
GCTGGCAGATTCTATGAATGCATTGACCCAACAAGTGGAGAAAGGTTTCCTTCATCTGAA
GTCATGAATAAGAGTCGGTGTGAAAGCCTTCTGTTTAACGAATCCATGCTATGGGAAAAT
GCAAAAATGAACTTTGATAATGTTGGAAATGGTTTCCTTTCTCTGCTTCAAGTAGCAACA
TTTAATGGATGGATCACTATTATGAATTCAGCAATTGATTCTGTTGCTGTTAATATACAG
CCTCATTTTGAAGTCAACATCTACATGTATTGTTACTTTATCAACTTTATTATATTTGGA
GTATTTCTCCCTCTGAGTATGCTGATTACTGTTATTATTGATAATTTCAACAAGCATAAA
ATAAAGCTGGGAGGCTCAAATATCTTTATAACGGTTAAACAGAGAAAACAGTACCGCAGG
CTGAAGAAGCTAATGTATGAGGATTCTCAAAGACCAGTACCTCGCCCATTAAACAAGCTC
CAAGGATTCATCTTTGATGTGGTAACAAGCCAAGCTTTTAATGTCATTGTTATGGTTCTT
ATATGTTTCCAAGCAATAGCCATGATGATAGACACTGATGTTCAGAGTCTACAAATGTCC
ATTGCTCTCTACTGGATTAACTCAATTTTTGTTATGCTATATACTATGGAATGTATACTG
AAGCTCATCGCTTTCCGTTGTTTTTATTTCACCATTGCGTGGAACATTTTTGATTTTATG
GTGGTTATTTTCTCCATCACAGGACTATGTCTGCCTATGACAGTAGGATCCTACCTTGTG
CCTCCTTCACTTGTGCAACTGATACTTCTCTCACGGATCATTCACATGCTGCGTCTTGGA
AAAGGACCAAAGGTGTTTCATAATCTGATGCTTCCTTTGATGCTGTCCCTCCCAGCATTA
TTGAACATCATTCTTCTCATCTTCCTGGTCATGTTCATCTATGCCGTATTTGGAATGTAT
AATTTTGCCTATGTTAAAAAAGAAGCTGGAATTAATGATGTGTCTAATTTTGAAACCTTT
GGCAACAGTATGCTCTGTCTTTTTCAAGTTGCAATATTTGCTGGTTGGGATGGGATGCTT
GATGCAATTTTCAACAGTAAATGGTCTGACTGTGATCCTGATAAAATTAACCCTGGGACT
CAAGTTAGAGGAGATTGTGGGAACCCCTCTGTTGGGATTTTTTATTTTGTCAGTTATATC
CTCATATCATGGCTGATCATTGTAAATATGTACATTGTTGTTGTCATGGAGTTTTTAAAT
ATTGCTTCTAAGAAGAAAAACAAGACCTTGAGTGAAGATGATTTTAGGAAATTCTTTCAG
GTATGGAAAAGGTTTGATCCTGATAGGACCCAGTACATAGACTCTAGCAAGCTTTCAGAT
TTTGCAGCTGCTCTTGATCCTCCTCTTTTCATGGCAAAACCAAACAAGGGCCAGCTCATT
GCTTTGGACCTCCCCATGGCTGTTGGGGACAGAATTCATTGCCTCGATATCTTACTTGCT
TTTACAAAGAGAGTTATGGGTCAAGATGTGAGGATGGAGAAAGTTGTTTCAGAAATAGAA
TCAGGGTTTTTGTTAGCCAACCCTTTTAAGATCACATGTGAGCCAATTACGACTACTTTG
AAACGAAAACAAGAGGCAGTTTCAGCAACCATCATTCAACGTGCTTATAAAAATTACCGC
TTGAGGCGAAATGACAAAAATACATCAGATATTCATATGATAGATGGTGACAGAGATGTT
CATGCTACTAAAGAAGGTGCCTATTTTGACAAAGCTAAGGAAAAGTCACCTATTCAAAGC
CAGATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1682 |
| Molecular Weight
| 193491.6 |
| Theoretical pI
| 8.02 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["114-140", "143-168", "180-202", "204-223", "240-264", "369-395", "501-524", "536-559", "567-590", "593-609", "630-650", "705-728", "930-958", "966-991", "997-1019", "1022-1040", "1060-1080", "1167-1193", "1248-1270", "1281-1305", "1312-1335", "1345-1369", "1379-1405", "1470-1496"]
|
| Protein Sequence
|
>Sodium channel protein type 7 subunit alpha
MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQG
MVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFF
QLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPW
NWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGV
IILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEG
ERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYH
QILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGK
ELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAK
TFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIG
NLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRM
LRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHI
DKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLV
LYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDH
VNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIAS
GESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNG
CRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQ
RKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR
EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLF
AGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVAT
FNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHK
IKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVL
ICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFM
VVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPAL
LNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGML
DAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLN
IASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLI
ALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTL
KRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQS
QI
|
| External Links |
|---|
| GenBank ID Protein
| 111378393 |
| UniProtKB/Swiss-Prot ID
| Q01118 |
| UniProtKB/Swiss-Prot Entry Name
| SCN7A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_002976.2 |
| GeneCard ID
| SCN7A |
| GenAtlas ID
| SCN7A |
| HGNC ID
| HGNC:10594 |
| References |
|---|
| General References
| Not Available |