| Identification |
|---|
| HMDB Protein ID
| CDBP04271 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium channel subunit beta-1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SCN1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in voltage-gated sodium channel activity |
| Specific Function
| Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Benzocaine Action Pathway |    | Not Available | | Bupivacaine Action Pathway |    | Not Available | | Chloroprocaine Action Pathway |    | Not Available | | Cocaine Action Pathway |    | Not Available | | Dibucaine Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.1 |
| SNPs
| SCN1B |
| Gene Sequence
|
>657 bp
ATGGGGAGGCTGCTGGCCTTAGTGGTCGGCGCGGCACTGGTGTCCTCAGCCTGCGGGGGC
TGCGTGGAGGTGGACTCGGAGACCGAGGCCGTGTATGGGATGACCTTCAAAATTCTTTGC
ATCTCCTGCAAGCGCCGCAGCGAGACCAACGCTGAGACCTTCACCGAGTGGACCTTCCGC
CAGAAGGGCACTGAGGAGTTTGTCAAGATCCTGCGCTATGAGAATGAGGTGTTGCAGCTG
GAGGAGGATGAGCGCTTCGAGGGCCGCGTGGTGTGGAATGGCAGCCGGGGCACCAAAGAC
CTGCAGGATCTGTCTATCTTCATCACCAATGTCACCTACAACCACTCGGGCGACTACGAG
TGCCACGTCTACCGCCTGCTCTTCTTCGAAAACTACGAGCACAACACCAGCGTCGTCAAG
AAGATCCACATTGAGGTAGTGGACAAAGCCAACAGAGACATGGCATCCATCGTGTCTGAG
ATCATGATGTATGTGCTCATTGTGGTGTTGACCATATGGCTCGTGGCAGAGATGATTTAC
TGCTACAAGAAGATCGCTGCCGCCACGGAGACTGCTGCACAGGAGAATGCCTCGGAATAC
CTGGCCATCACCTCTGAGAGCAAAGAGAACTGCACGGGCGTCCAGGTGGCCGAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 218 |
| Molecular Weight
| 24707.0 |
| Theoretical pI
| 4.56 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sodium channel subunit beta-1
MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFR
QKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYE
CHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIY
CYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
|
| External Links |
|---|
| GenBank ID Protein
| 307415 |
| UniProtKB/Swiss-Prot ID
| Q07699 |
| UniProtKB/Swiss-Prot Entry Name
| SCN1B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L10338 |
| GeneCard ID
| SCN1B |
| GenAtlas ID
| SCN1B |
| HGNC ID
| HGNC:10586 |
| References |
|---|
| General References
| Not Available |