| Identification |
|---|
| HMDB Protein ID
| CDBP04267 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium-dependent neutral amino acid transporter SLC6A17 |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 6 member 17
- Sodium-dependent neurotransmitter transporter NTT4
|
| Gene Name
| SLC6A17 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in neurotransmitter:sodium symporter activity |
| Specific Function
| Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity).
|
| GO Classification
|
| Biological Process |
| leucine transport |
| proline transport |
| alanine transport |
| glycine transport |
| Cellular Component |
| cell junction |
| synaptic vesicle |
| integral to plasma membrane |
| synaptic vesicle membrane |
| Component |
| integral to plasma membrane |
| membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neurotransmitter transporter activity |
| neurotransmitter:sodium symporter activity |
| transmembrane transporter activity |
| transporter activity |
| Molecular Function |
| neurotransmitter:sodium symporter activity |
| Process |
| establishment of localization |
| transport |
| neurotransmitter transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p13.3 |
| SNPs
| SLC6A17 |
| Gene Sequence
|
>2184 bp
ATGCCGAAGAACAGCAAAGTGACCCAGCGTGAGCACAGCAGTGAGCATGTCACTGAGTCC
GTGGCCGACCTGCTGGCCCTCGAGGAGCCTGTGGACTATAAGCAGAGTGTACTGAATGTG
GCTGGTGAGGCAGGCGGCAAGCAGAAGGCGGTGGAGGAGGAGCTGGATGCAGAGGACCGG
CCGGCCTGGAACAGTAAGCTGCAGTACATCCTGGCCCAGATTGGCTTCTCTGTGGGCCTC
GGCAACATCTGGAGGTTCCCCTACCTGTGCCAGAAAAATGGAGGAGGTGCTTACCTGGTG
CCCTACCTGGTGCTGCTGATCATCATCGGGATCCCCCTCTTCTTCCTGGAGCTGGCTGTG
GGTCAGAGGATCCGCCGCGGCAGCATCGGTGTGTGGCACTATATATGTCCCCGCCTGGGG
GGCATCGGCTTCTCCAGCTGCATAGTCTGTCTCTTTGTGGGGCTGTATTATAATGTGATC
ATCGGGTGGAGCATCTTCTATTTCTTCAAGTCCTTCCAGTACCCGCTGCCCTGGAGTGAA
TGTCCTGTCGTCAGGAATGGGAGCGTGGCAGTGGTGGAGGCAGAGTGTGAAAAGAGCTCA
GCCACTACCTACTTCTGGTACCGAGAGGCCTTGGACATCTCTGACTCCATCTCGGAGAGT
GGGGGCCTCAACTGGAAGATGACCCTGTGCCTCCTCGTGGCCTGGAGCATCGTGGGGATG
GCTGTCGTTAAGGGCATCCAGTCCTCGGGGAAGGTGATGTATTTCAGCTCCCTCTTCCCC
TACGTGGTGCTGGCCTGCTTCCTGGTCCGGGGGCTGTTGCTGCGAGGGGCAGTTGATGGC
ATCCTACACATGTTCACTCCCAAGCTGGACAAGATGCTGGACCCCCAGGTGTGGCGGGAG
GCAGCTACCCAGGTCTTCTTTGCCTTGGGCCTGGGCTTTGGTGGTGTCATTGCCTTCTCC
AGCTACAATAAGCAGGACAACAACTGCCACTTCGATGCCGCCCTGGTGTCCTTCATCAAC
TTCTTCACGTCAGTGTTGGCCACCCTCGTGGTGTTTGCTGTGCTGGGCTTCAAGGCCAAC
ATCATGAATGAGAAGTGTGTGGTCGAGAATGCTGAGAAAATCCTAGGGTACCTTAACACC
AACGTCCTGAGCCGGGACCTCATCCCACCCCACGTCAACTTCTCCCACCTGACCACAAAG
GACTACATGGAGATGTACAATGTCATCATGACCGTGAAGGAGGACCAGTTCTCAGCCCTG
GGCCTTGACCCCTGCCTTCTGGAGGACGAGCTGGACAAGTCCGTGCAGGGCACAGGCCTG
GCCTTCATCGCCTTCACTGAGGCCATGACGCACTTCCCCGCCTCCCCGTTCTGGTCCGTC
ATGTTCTTCTTGATGCTTATCAACCTGGGCCTGGGCAGCATGATCGGGACCATGGCAGGC
ATCACCACGCCCATCATCGACACCTTCAAGGTGCCCAAGGAGATGTTCACAGTGGGCTGC
TGTGTCTTTGCATTCCTCGTGGGGCTGTTGTTCGTCCAGCGCTCCGGAAACTACTTTGTC
ACCATGTTCGATGACTACTCGGCCACCCTGCCACTCACTCTCATCGTCATCCTTGAGAAC
ATCGCTGTGGCCTGGATTTATGGAACCAAGAAGTTCATGCAGGAGCTGACGGAGATGCTG
GGCTTCCGCCCCTACCGCTTCTATTTCTACATGTGGAAGTTCGTGTCTCCACTATGCATG
GCTGTGCTCACCACAGCCAGCATCATCCAGCTGGGGGTCACGCCCCCGGGCTACAGCGCC
TGGATCAAGGAGGAGGCTGCCGAGCGCTACCTGTATTTCCCCAACTGGGCCATGGCACTC
CTGATCACCCTCATCGTCGTGGCGACGCTGCCCATCCCTGTGGTGTTCGTCCTGCGGCAC
TTCCACCTGCTCTCTGATGGCTCCAACACCCTCTCCGTGTCCTACAAGAAGGGCCGCATG
ATGAAGGACATCTCCAACCTGGAGGAGAACGATGAGACCCGCTTCATCCTCAGCAAGGTG
CCCAGTGAGGCACCTTCCCCCATGCCCACTCACCGTTCCTATCTGGGGCCCGGCAGCACA
TCACCCCTGGAGACCAGCGGTAACCCCAATGGACGCTATGGGAGCGGCTACCTGCTGGCC
AGCACCCCTGAGTCGGAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 727 |
| Molecular Weight
| 81000.71 |
| Theoretical pI
| 5.981 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Orphan sodium- and chloride-dependent neurotransmitter transporter NTT4
MPKNSKVTQREHSSEHVTESVADLLALEEPVDYKQSVLNVAGEAGGKQKAVEEELDAEDR
PAWNSKLQYILAQIGFSVGLGNIWRFPYLCQKNGGGAYLVPYLVLLIIIGIPLFFLELAV
GQRIRRGSIGVWHYICPRLGGIGFSSCIVCLFVGLYYNVIIGWSIFYFFKSFQYPLPWSE
CPVVRNGSVAVVEAECEKSSATTYFWYREALDISDSISESGGLNWKMTLCLLVAWSIVGM
AVVKGIQSSGKVMYFSSLFPYVVLACFLVRGLLLRGAVDGILHMFTPKLDKMLDPQVWRE
AATQVFFALGLGFGGVIAFSSYNKQDNNCHFDAALVSFINFFTSVLATLVVFAVLGFKAN
IMNEKCVVENAEKILGYLNTNVLSRDLIPPHVNFSHLTTKDYMEMYNVIMTVKEDQFSAL
GLDPCLLEDELDKSVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMIGTMAG
ITTPIIDTFKVPKEMFTVGCCVFAFLVGLLFVQRSGNYFVTMFDDYSATLPLTLIVILEN
IAVAWIYGTKKFMQELTEMLGFRPYRFYFYMWKFVSPLCMAVLTTASIIQLGVTPPGYSA
WIKEEAAERYLYFPNWAMALLITLIVVATLPIPVVFVLRHFHLLSDGSNTLSVSYKKGRM
MKDISNLEENDETRFILSKVPSEAPSPMPTHRSYLGPGSTSPLETSGNPNGRYGSGYLLA
STPESEL
|
| External Links |
|---|
| GenBank ID Protein
| 56204187 |
| UniProtKB/Swiss-Prot ID
| Q9H1V8 |
| UniProtKB/Swiss-Prot Entry Name
| S6A17_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL137790 |
| GeneCard ID
| SLC6A17 |
| GenAtlas ID
| SLC6A17 |
| HGNC ID
| HGNC:31399 |
| References |
|---|
| General References
| Not Available |