Showing Protein Sodium-dependent neutral amino acid transporter B(0)AT2 (CDBP04265)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP04265
Secondary Accession Numbers Not Available
Name Sodium-dependent neutral amino acid transporter B(0)AT2
Description Not Available
Synonyms
  1. Orphan transporter v7-3
  2. Solute carrier family 6 member 15
  3. Sodium- and chloride-dependent neurotransmitter transporter NTT73
  4. Sodium-coupled branched-chain amino-acid transporter 1
  5. Transporter v7-3
Gene Name SLC6A15
Protein Type Transporter
Biological Properties
General Function Involved in neurotransmitter:sodium symporter activity
Specific Function Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
GO Classification
Biological Process
leucine transport
proline transport
transmembrane transport
Cellular Component
plasma membrane
integral to membrane
integral to plasma membrane
Component
intrinsic to membrane
integral to membrane
integral to plasma membrane
membrane
cell part
membrane part
Function
neurotransmitter transporter activity
neurotransmitter:sodium symporter activity
transmembrane transporter activity
transporter activity
Molecular Function
neurotransmitter:sodium symporter activity
neurotransmitter transporter activity
proline:sodium symporter activity
Process
establishment of localization
transport
neurotransmitter transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location 12
Locus 12q21.3
SNPs SLC6A15
Gene Sequence 
>2193 bp
ATGCCCAAAAATAGCAAGGTGGTAAAAAGAGAATTAGATGATGATGTTACTGAGTCTGTC
AAAGACCTTCTTTCCAATGAAGACGCAGCTGATGATGCTTTTAAGACAAGTGAACTAATT
GTTGATGGCCAGGAAGAGAAAGATACAGATGTTGAAGAAGGATCTGAAGTCGAAGATGAA
AGACCAGCTTGGAACAGTAAACTACAATACATCCTGGCCCAAGTTGGATTTTCTGTAGGT
TTAGGAAATGTGTGGCGATTTCCATACCTATGTCAGAAGAATGGGGGCGGTGCATATCTT
TTACCATATTTAATACTACTTATGGTAATAGGTATTCCCCTTTTTTTCTTGGAACTCTCT
GTGGGTCAAAGAATTCGGCGAGGCAGCATTGGTGTATGGAATTACATAAGCCCTAAACTG
GGCGGGATTGGATTTGCAAGTTGTGTAGTGTGCTATTTTGTAGCTCTCTACTACAACGTC
ATCATTGGCTGGAGTTTGTTTTATTTTTCTCAGTCTTTTCAGCAACCCCTGCCTTGGGAT
CAGTGTCCTTTGGTGAAAAATGCTTCACACACTTTTGTAGAACCAGAATGTGAACAAAGT
TCTGCCACCACCTATTACTGGTACAGGGAAGCACTGAATATTTCAAGTTCCATTTCTGAA
AGTGGGGGCTTAAACTGGAAGATGACCATCTGCTTGTTGGCTGCCTGGGTCATGGTTTGC
TTGGCTATGATCAAAGGCATTCAGTCTTCTGGAAAAATCATATATTTTAGTTCTCTGTTT
CCATATGTGGTACTTATTTGCTTCCTCATCAGAGCATTCCTTTTAAATGGTTCAATTGAT
GGCATTCGCCACATGTTTACCCCTAAGCTTGAAATAATGCTGGAGCCCAAGGTCTGGAGA
GAAGCTGCTACTCAAGTGTTCTTTGCCTTAGGTCTGGGATTTGGTGGTGTCATTGCCTTT
TCAAGCTACAACAAGAGAGACAACAACTGCCACTTTGATGCTGTCCTGGTGTCCTTCATC
AATTTTTTCACTTCTGTCCTGGCAACATTGGTGGTGTTTGCAGTTCTGGGCTTCAAAGCA
AATGTCATAAATGAGAAATGCATTACACAAAATTCAGAGACGATCATGAAATTTTTGAAA
ATGGGGAACATTAGTCAGGATATTATTCCCCATCATATCAACCTTTCAACTGTTACTGCA
GAAGATTATCATTTAGTTTATGACATCATTCAAAAAGTGAAAGAAGAAGAGTTTCCTGCT
CTTCATCTCAATTCCTGTAAAATTGAAGAAGAGCTAAATAAAGCTGTTCAGGGGACCGGC
TTAGCTTTTATTGCCTTTACAGAAGCGATGACACATTTTCCTGCATCTCCCTTCTGGTCA
GTGATGTTTTTCCTCATGCTGGTCAATCTAGGCCTTGGCAGTATGTTTGGAACCATTGAA
GGGATTGTCACGCCTATTGTGGACACTTTCAAAGTGAGGAAAGAAATTCTTACTGTTATC
TGTTGTCTTCTGGCATTTTGTATTGGCCTGATATTTGTGCAACGCTCTGGAAATTACTTT
GTTACAATGTTTGATGATTATTCTGCTACACTGCCTCTGCTAATTGTAGTCATTTTGGAG
AATATTGCTGTATGCTTTGTTTATGGCATAGATAAGTTTATGGAAGACCTAAAAGATATG
CTGGGCTTTGCTCCCAGCAGATATTACTACTATATGTGGAAATATATTTCTCCTCTAATG
CTATTATCATTGCTAATAGCTAGTGTTGTGAATATGGGATTAAGTCCTCCTGGCTATAAC
GCATGGATTGAAGATAAGGCATCTGAAGAATTTCTGAGCTATCCAACATGGGGACTGGTT
GTTTGTGTCTCTCTGGTTGTCTTTGCAATACTCCCAGTCCCTGTAGTTTTCATTGTTCGT
CGCTTCAACCTTATAGATGATAGTTCTGGTAATTTAGCATCTGTGACCTATAAGAGAGGA
AGGGTCCTGAAAGAGCCTGTGAACTTAGAGGGCGATGATACAAGCCTCATTCACGGAAAA
ATACCGAGCGAGATGCCATCTCCAAATTTTGGTAAAAATATTTATCGAAAACAGAGTGGA
TCCCCAACTCTGGATACTGCTCCCAATGGACGGTATGGAATAGGGTACTTGATGGCAGAT
ATTATGCCAGATATGCCAGAATCTGATTTGTAG
Protein Properties
Number of Residues 730
Molecular Weight 69885.24
Theoretical pI 6.007
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
IMPDMPESDL
GenBank ID Protein 11907841
UniProtKB/Swiss-Prot ID Q9H2J7
UniProtKB/Swiss-Prot Entry Name S6A15_HUMAN
PDB IDs Not Available
GenBank Gene ID AF265577
GeneCard ID SLC6A15
GenAtlas ID SLC6A15
HGNC ID HGNC:13621
References
General References Not Available