| Identification |
|---|
| HMDB Protein ID
| CDBP04259 |
| Secondary Accession Numbers
| Not Available |
| Name
| Regulator of differentiation 1 |
| Description
| Not Available |
| Synonyms
|
- Rod1
|
| Gene Name
| ROD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| May play a role in regulation of differentiation. In vitro, binds RNA, preferentially to both poly(G) and poly(U). Overexpressed, blocks differentiation of K562 leukemia cells following treatment with phorbol esters or sodium butyrate without affecting proliferation |
| GO Classification
|
| Component |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| organelle |
| Function |
| binding |
| nucleotide binding |
| nucleic acid binding |
| rna binding |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
| mrna processing |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q32 |
| SNPs
| ROD1 |
| Gene Sequence
|
>1659 bp
ATGGATGGTGTTGTTACAGATCTTATAACAGTCGGTTTAAAGCGGGGATCTGATGAGCTT
CTTTCTTCTGGCATCATTAACGGACCTTTTACCATGAATAGTTCTACTCCTTCTACAGCT
AATGGGAATGACAGCAAGAAATTTAAACGAGATAGACCTCCCTGTTCGCCTTCCCGTGTT
CTCCATCTTCGAAAAATTCCATGTGATGTCACCGAAGCAGAGATCATATCATTAGGTCTA
CCATTTGGCAAAGTAACTAATCTTTTGATGTTGAAAGGAAAAAGCCAGGCTTTCTTAGAA
ATGGCTTCTGAGGAAGCTGCCGTTACTATGGTGAATTATTACACTCCTATTACTCCTCAC
CTTCGAAGCCAGCCTGTTTATATTCAGTATTCCAATCACAGAGAACTTAAGACTGACAAT
CTACCTAATCAAGCTCGAGCCCAAGCTGCACTGCAGGCTGTCAGTGCCGTCCAATCAGGA
AGCCTGGCCCTTTCTGGAGGTCCTTCCAATGAAGGCACAGTCCTACCTGGGCAGAGCCCT
GTGCTTCGAATAATTATTGAAAACCTCTTTTACCCTGTTACCCTGGAAGTTCTTCATCAG
ATATTTTCTAAATTTGGCACAGTCTTGAAGATTATCACCTTTACAAAGAATAATCAGTTT
CAAGCCTTGCTTCAGTATGCTGACCCAGTAAATGCACATTATGCCAAAATGGCTCTGGAT
GGCCAGAATATCTATAATGCATGCTGCACTCTGCGCATTGACTTCTCCAAGCTCACCAGC
CTTAATGTGAAATATAATAATGACAAAAGCAGAGACTTCACTCGCTTAGACCTTCCTACT
GGTGATGGCCAGCCATCCCTTGAACCCCCTATGGCTGCTGCTTTTGGTGCACCGGGTATA
ATTTCTTCACCATATGCAGGGGCTGCTGGATTTGCCCCAGCCATTGGATTTCCTCAAGCT
ACAGGTCTATCAGTTCCAGCTGTTCCTGGAGCTCTTGGTCCTCTCACAATCACCTCTTCT
GCTGTCACTGGAAGGATGGCCATTCCTGGGGCTAGTGGTATACCAGGAAATTCTGTTCTA
CTCGTCACAAATCTCAATCCTGATCTTATCACACCACATGGGCTTTTTATCCTATTTGGA
GTCTATGGTGATGTACATCGAGTGAAGATTATGTTTAATAAGAAAGAAAATGCCTTGGTT
CAGATGGCGGATGCAAATCAAGCTCAGCTAGCAATGAACCATCTAAGTGGTCAGAGACTT
TATGGGAAAGTGCTTCGTGCTACACTGTCCAAACATCAAGCAGTACAGCTTCCTCGAGAG
GGACAAGAAGACCAAGGTCTGACTAAGGATTTCAGCAATAGTCCTTTGCATCGCTTTAAA
AAGCCGGGCTCTAAAAACTTCCAGAATATCTTTCCACCATCAGCCACTCTGCATCTTTCC
AACATTCCCCCTTCTGTTACAGTGGATGATCTGAAGAACCTTTTCATAGAAGCTGGATGT
TCAGTGAAGGCTTTTAAATTCTTTCAGAAAGATCGCAAAATGGCGCTCATTCAATTGGGA
TCTGTGGAAGAAGCAATTCAGGCCCTCATTGAGCTTCATAACCATGACCTTGGAGAAAAT
CACCACCTCAGAGTTTCCTTCTCAAAATCTACAATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 552 |
| Molecular Weight
| 59689.0 |
| Theoretical pI
| 9.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Regulator of differentiation 1
MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRV
LHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPH
LRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSP
VLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALD
GQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGI
ISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVL
LVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLS
NIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGEN
HHLRVSFSKSTI
|
| External Links |
|---|
| GenBank ID Protein
| 38569466 |
| UniProtKB/Swiss-Prot ID
| O95758 |
| UniProtKB/Swiss-Prot Entry Name
| ROD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005156.5 |
| GeneCard ID
| ROD1 |
| GenAtlas ID
| ROD1 |
| HGNC ID
| HGNC:10253 |
| References |
|---|
| General References
| Not Available |