| Identification |
|---|
| HMDB Protein ID
| CDBP04258 |
| Secondary Accession Numbers
| Not Available |
| Name
| Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 |
| Description
| Not Available |
| Synonyms
|
- B-ind1
- Butyrate-induced protein 1
- HACD3
- Protein tyrosine phosphatase-like protein PTPLAD1
- Protein-tyrosine phosphatase-like A domain-containing protein 1
- hB-ind1
- 3-hydroxyacyl-CoA dehydratase 3
|
| Gene Name
| PTPLAD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in GTPase activator activity |
| Specific Function
| Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.
|
| GO Classification
|
| Biological Process |
| Rac protein signal transduction |
| Rho protein signal transduction |
| fatty acid biosynthetic process |
| activation of JUN kinase activity |
| I-kappaB kinase/NF-kappaB cascade |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Molecular Function |
| GTPase activator activity |
| lyase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q22.2 |
| SNPs
| PTPLAD1 |
| Gene Sequence
|
>1089 bp
ATGGAGAATCAGGTGTTGACGCCGCATGTCTACTGGGCTCAGCGACACCGCGAGCTATAT
CTGCGCGTGGAGCTGAGTGACGTACAGAACCCTGCCATCAGCATCACTGAAAACGTGCTG
CATTTCAAAGCTCAAGGACATGGTGCCAAAGGAGACAATGTCTATGAATTTCACCTGGAG
TTCTTAGACCTTGTGAAACCAGAGCCTGTTTACAAACTGACCCAGAGGCAGGTAAACATT
ACAGTACAGAAGAAAGTGAGTCAGTGGTGGGAGAGACTCACAAAGCAGGAAAAGCGACCA
CTGTTTTTGGCTCCTGACTTTGATCGTTGGCTGGATGAATCTGATGCGGAAATGGAGCTC
AGAGCTAAGGAAGAAGAGCGCCTAAATAAACTCCGACTGGAAAGCGAAGGCTCTCCTGAA
ACTCTTACAAACTTAAGGAAAGGATACCTGTTTATGTATAATCTTGTGCAATTCTTGGGA
TTCTCCTGGATCTTTGTCAACCTGACTGTGCGATTCTGTATCTTGGGAAAAGAGTCCTTT
TATGACACATTCCATACTGTGGCTGACATGATGTATTTCTGCCAGATGCTGGCAGTTGTG
GAAACTATCAATGCAGCAATTGGAGTCACTACGTCACCGGTGCTGCCTTCTCTGATCCAG
CTTCTTGGAAGAAATTTTATTTTGTTTATCATCTTTGGCACCATGGAAGAAATGCAGAAC
AAAGCTGTGGTTTTCTTTGTGTTTTATTTGTGGAGTGCAATTGAAATTTTCAGGTACTCT
TTCTACATGCTGACGTGCATTGACATGGATTGGAAGGTGCTCACATGGCTTCGTTACACT
CTGTGGATTCCCTTATATCCACTGGGATGTTTGGCGGAAGCTGTCTCAGTGATTCAGTCC
ATTCCAATATTCAATGAGACCGGACGATTCAGTTTCACATTGCCATATCCAGTGAAAATC
AAAGTTAGATTTTCCTTTTTTCTTCAGATTTATCTTATAATGATATTTTTAGGTTTATAC
ATAAATTTTCGTCACCTTTATAAACAGCGCAGACGGCGCTATGGACAAAAAAAGAAAAAG
ATCCACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 362 |
| Molecular Weight
| 43159.225 |
| Theoretical pI
| 8.946 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-hydroxyacyl-CoA dehydratase 3
MENQVLTPHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLE
FLDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWLDESDAEMEL
RAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESF
YDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTMEEMQN
KAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQS
IPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK
IH
|
| External Links |
|---|
| GenBank ID Protein
| 117168248 |
| UniProtKB/Swiss-Prot ID
| Q9P035 |
| UniProtKB/Swiss-Prot Entry Name
| HACD3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_016395.2 |
| GeneCard ID
| PTPLAD1 |
| GenAtlas ID
| PTPLAD1 |
| HGNC ID
| HGNC:24175 |
| References |
|---|
| General References
| Not Available |