Showing Protein Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (CDBP04251)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP04251
Secondary Accession Numbers Not Available
Name Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Description Not Available
Synonyms Not Available
Gene Name HCN3
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions
GO Classification
Component
cell part
membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
establishment of localization
transport
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q22
SNPs HCN3
Gene Sequence 
>2325 bp
ATGGAGGCAGAGCAGCGGCCGGCGGCGGGGGCCAGCGAAGGGGCGACCCCTGGACTGGAG
GCGGTGCCTCCCGTTGCTCCCCCGCCTGCGACCGCGGCCTCAGGTCCGATCCCCAAATCT
GGGCCTGAGCCTAAGAGGAGGCACCTTGGGACGCTGCTCCAGCCTACGGTCAACAAGTTC
TCCCTTCGGGTGTTCGGCAGCCACAAAGCAGTGGAAATCGAGCAGGAGCGGGTGAAGTCA
GCGGGGGCCTGGATCATCCACCCCTACAGCGACTTCCGGTTTTACTGGGACCTGATCATG
CTGCTGCTGATGGTGGGGAACCTCATCGTCCTGCCTGTGGGCATCACCTTCTTCAAGGAG
GAGAACTCCCCGCCTTGGATCGTCTTCAACGTATTGTCTGATACTTTCTTCCTACTGGAT
CTGGTGCTCAACTTCCGAACGGGCATCGTGGTGGAGGAGGGTGCTGAGATCCTGCTGGCA
CCGCGGGCCATCCGCACGCGCTACCTGCGCACCTGGTTCCTGGTTGACCTCATCTCTTCT
ATCCCTGTGGATTACATCTTCCTAGTGGTGGAGCTGGAGCCACGGTTGGACGCTGAGGTC
TACAAAACGGCACGGGCCCTACGCATCGTTCGCTTCACCAAGATCCTAAGCCTGCTGAGG
CTGCTCCGCCTCTCCCGCCTCATCCGCTACATACACCAGTGGGAGGAGATCTTTCACATG
ACCTATGACCTGGCCAGTGCTGTGGTTCGCATCTTCAACCTCATTGGGATGATGCTGCTG
CTATGTCACTGGGATGGCTGTCTGCAGTTCCTGGTGCCCATGCTGCAGGACTTCCCTCCC
GACTGCTGGGTCTCCATCAACCACATGGTGAACCACTCGTGGGGCCGCCAGTATTCCCAT
GCCCTGTTCAAGGCCATGAGCCACATGCTGTGCATTGGCTATGGGCAGCAGGCACCTGTA
GGCATGCCCGACGTCTGGCTCACCATGCTCAGCATGATCGTAGGTGCCACATGCTACGCC
ATGTTCATCGGCCATGCCACGGCACTCATCCAGTCCCTGGACTCTTCCCGGCGTCAGTAC
CAGGAGAAGTACAAGCAGGTGGAGCAGTACATGTCCTTCCACAAGCTGCCAGCAGACACG
CGGCAGCGCATCCACGAGTACTATGAGCACCGCTACCAGGGCAAGATGTTCGATGAGGAA
AGCATCCTGGGCGAGCTGAGCGAGCCGCTTCGCGAGGAGATCATTAACTTCACCTGTCGG
GGCCTGGTGGCCCACATGCCGCTGTTTGCCCATGCCGACCCCAGCTTCGTCACTGCAGTT
CTCACCAAGCTGCGCTTTGAGGTCTTCCAGCCGGGGGATCTCGTGGTGCGTGAGGGCTCC
GTGGGGAGGAAGATGTACTTCATCCAGCATGGGCTGCTCAGTGTGCTGGCCCGCGGCGCC
CGGGACACACGCCTCACCGATGGATCCTACTTTGGGGAGATCTGCCTGCTAACTAGGGGC
CGGCGCACAGCCAGTGTTCGGGCTGACACCTACTGCCGCCTTTACTCACTCAGCGTGGAC
CATTTCAATGCTGTGCTTGAGGAGTTCCCCATGATGCGCCGGGCCTTTGAGACTGTGGCC
ATGGATCGGCTGCTCCGCATCGGCAAGAAGAATTCCATACTGCAGCGGAAGCGCTCCGAG
CCAAGTCCAGGCAGCAGTGGTGGCATCATGGAGCAGCACTTGGTGCAACATGACAGAGAC
ATGGCTCGGGGTGTTCGGGGTCGGGCCCCGAGCACAGGAGCTCAGCTTAGTGGAAAGCCA
GTACTGTGGGAGCCACTGGTACATGCGCCCCTTCAGGCAGCTGCTGTGACCTCCAATGTG
GCCATTGCCCTGACTCATCAGCGGGGCCCTCTGCCCCTCTCCCCTGACTCTCCAGCCACC
CTCCTTGCTCGCTCTGCTTGGCGCTCAGCAGGCTCTCCAGCTTCCCCGCTGGTGCCCGTC
CGAGCTGGCCCATGGGCATCCACCTCCCGCCTGCCCGCCCCACCTGCCCGAACCCTGCAC
GCCAGCCTATCCCGGGCAGGGCGCTCCCAGGTCTCCCTGCTGGGTCCCCCTCCAGGAGGA
GGTGGACGGCGGCTAGGACCTCGGGGCCGCCCACTCTCAGCCTCCCAACCCTCTCTGCCT
CAGCGGGCAACAGGCGATGGCTCTCCTGGGCGTAAGGGATCAGGAAGTGAGCGGCTGCCT
CCCTCAGGGCTCCTGGCCAAACCTCCAAGGACAGCCCAGCCCCCCAGGCCACCAGTGCCT
GAGCCAGCCACACCCCGGGGTCTCCAGCTTTCTGCCAACATGTAA
Protein Properties
Number of Residues 774
Molecular Weight 86031.0
Theoretical pI 10.12
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["98-118", "125-145", "172-192", "202-222", "254-274", "330-350"]
Protein Sequence 
>Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF
SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE
ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS
IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM
TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH
ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY
QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR
GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA
RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA
MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP
VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV
RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP
QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
GenBank ID Protein 38327037
UniProtKB/Swiss-Prot ID Q9P1Z3
UniProtKB/Swiss-Prot Entry Name HCN3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_020897.1
GeneCard ID HCN3
GenAtlas ID HCN3
HGNC ID HGNC:19183
References
General References Not Available