4228 CDBP04227 Histone-lysine N-methyltransferase SETD2 Q9BYW2 SETD2_HUMAN true false Enzyme Homo_sapiens SETD2 2564 287594.195 6.137 Involved in histone-lysine N-methyltransferase activity Histone methyltransferase that methylates 'Lys-36' of histone H3. H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation. Probably plays a role in chromatin structure modulation during elongation via its interaction with hyperphosphorylated POLR2A. Binds DNA at promoters. May also act as a transcription activator that binds to promoters. Binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression. 2A7O;4FMU;4H12 NM_014159.6 197313748 SETD2 3 3p21.31 SETD2 HGNC:18420 true hsa:29072 NP_054878.5:NM_014159.6 Ubiquitously expressed. Specifically interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Binds specifically to CTD heptad repeats doubly phosphorylated on 'Ser-2' and 'Ser-5' of each heptad. Interacts with HTT 2020-06-12T23:07:23Z 2020-07-28T02:29:33Z 0 1 1