| Identification |
|---|
| HMDB Protein ID
| CDBP04210 |
| Secondary Accession Numbers
| Not Available |
| Name
| 7SK snRNA methylphosphate capping enzyme |
| Description
| Not Available |
| Synonyms
|
- Bicoid-interacting protein 3 homolog
- Bin3 homolog
- MePCE
|
| Gene Name
| MEPCE |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methyltransferase activity |
| Specific Function
| S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it |
| GO Classification
|
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring one-carbon groups |
| methyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q22.1 |
| SNPs
| MEPCE |
| Gene Sequence
|
>2070 bp
ATGATCGAGATGGCGGCGGAGAAGGAGCCGTTTCTGGTGCCGGCCCCGCCGCCGCCGCTC
AAAGATGAGTCGGGCGGAGGGGGCGGCCCCACGGTGCCACCGCACCAAGAGGCCGCCTCT
GGGGAGCTCCGCGGCGGGACGGAGCGTGGTCCGGGTCGTTGCGCGCCATCTGCGGGGTCC
CCAGCCGCTGCGGTCGGTCGGGAAAGCCCCGGGGCCGCGGCCACCTCCTCCAGTGGTCCC
CAGGCGCAGCAGCACCGAGGGGGCGGCCCCCAGGCGCAGTCGCATGGGGAGGCCCGCCTG
TCGGATCCCCCGGGGCGAGCCGCTCCCCCGGACGTGGGGGAGGAGCGCCGGGGAGGGGGC
GGGACAGAGCTGGGTCCCCCTGCTCCTCCTCGACCCCGCAATGGCTATCAGCCCCACCGG
CCACCTGGGGGGGGCGGGGGCAAGAGGAGAAATAGCTGTAATGTAGGGGGAGGCGGGGGA
GGCTTCAAACATCCGGCCTTCAAGAGGCGCAGGCGGGTGAATTCGGACTGTGACTCTGTG
TTACCCTCCAACTTCCTCCTGGGGGGCAATATCTTTGATCCCCTGAACCTGAATAGCCTC
CTGGATGAGGAAGTGAGCCGCACTCTCAACGCGGAGACCCCTAAGTCATCCCCCCTTCCG
GCCAAAGGGCGAGATCCGGTGGAGATCCTCATCCCCAAAGATATTACTGACCCGCTCAGT
CTCAATACTTGCACTGATGAGGGCCATGTAGTTCTTGCTTCGCCACTCAAGACTGGTCGG
AAGCGGCATAGACACCGGGGACAGCACCACCAGCAGCAGCAGGCAGCCGGAGGGAGTGAG
AGTCACCCCGTGCCGCCCACAGCCCCTCTCACCCCCTTACTCCACGGGGAGGGCGCCTCA
CAGCAGCCGCGGCACAGGGGCCAGAACCGGGATGCCCCCCAACCCTATGAACTCAACACA
GCCATCAACTGCAGGGATGAAGTGGTGTCTCCCCTTCCATCTGCTCTGCAGGGTCCCTCA
GGCTCCCTATCAGCCCCTCCAGCTGCCTCAGTTATCTCTGCACCCCCATCTTCCTCCTCC
CGACATCGCAAACGTCGCAGGACTTCCAGCAAGTCGGAGGCAGGGGCTAGGGGTGGAGGC
CAGGGTTCCAAGGAAAAGGGCCGAGGGAGTTGGGGAGGCCGCCACCACCACCACCACCCA
CTGCCTGCAGCAGGCTTCAAAAAGCAACAGCGCAAGTTCCAGTATGGGAATTATTGCAAA
TACTATGGGTACCGCAATCCTTCCTGTGAGGATGGGCGCCTTCGGGTGTTGAAGCCTGAG
TGGTTTCGGGGCCGGGACGTCCTAGATCTGGGCTGCAATGTGGGCCATCTGACCCTGAGC
ATTGCCTGCAAGTGGGGCCCGTCCCGCATGGTGGGCCTGGATATCGATTCCCGGCTCATC
CATTCTGCCCGCCAAAACATCCGACACTACCTTTCCGAGGAGCTGCGTCTCCCACCCCAG
ACTTTGGAAGGGGACCCGGGGGCAGAGGGTGAGGAAGGGACCACCACCGTTCGAAAGAGG
AGCTGCTTCCCAGCCTCGCTGACTGCCAGCCGGGGTCCCATCGCTGCCCCCCAAGTGCCC
TTGGATGGAGCGGACACATCAGTCTTCCCCAACAATGTTGTCTTCGTCACGGGTAATTAT
GTGCTGGATCGAGATGACCTGGTGGAGGCCCAAACACCTGAGTATGATGTGGTGCTCTGC
CTCAGCCTCACCAAGTGGGTGCATCTGAACTGGGGAGACGAGGGCCTGAAGCGCATGTTT
CGCCGGATCTACCGGCACCTACGCCCTGGGGGCATCCTGGTCCTAGAGCCCCAACCCTGG
TCGTCGTATGGCAAGAGAAAGACTCTTACAGAAACGATCTACAAGAACTACTACCGAATC
CAATTGAAGCCAGAGCAGTTCAGTTCCTACCTGACATCCCCAGACGTGGGCTTCTCCAGC
TATGAGCTTGTGGCCACACCCCACAACACCTCTAAAGGCTTCCAGCGTCCTGTGTACCTG
TTCCACAAGGCCCGATCCCCCAGCCACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 689 |
| Molecular Weight
| 74354.7 |
| Theoretical pI
| 10.01 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>7SK snRNA methylphosphate capping enzyme
MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGS
PAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGG
GTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSV
LPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLS
LNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGAS
QQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSS
RHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCK
YYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLI
HSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVP
LDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMF
RRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSS
YELVATPHNTSKGFQRPVYLFHKARSPSH
|
| External Links |
|---|
| GenBank ID Protein
| 47271406 |
| UniProtKB/Swiss-Prot ID
| Q7L2J0 |
| UniProtKB/Swiss-Prot Entry Name
| MEPCE_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_019606.5 |
| GeneCard ID
| MEPCE |
| GenAtlas ID
| MEPCE |
| HGNC ID
| HGNC:20247 |
| References |
|---|
| General References
| Not Available |