Showing Protein Protein tyrosine phosphatase type IVA 2 (CDBP04168)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04168
Secondary Accession Numbers Not Available
Name Protein tyrosine phosphatase type IVA 2
Description Not Available
Synonyms
  1. HU-PP-1
  2. OV-1
  3. PRL-2
  4. PTP(CAAXII)
  5. Protein-tyrosine phosphatase 4a2
  6. Protein-tyrosine phosphatase of regenerating liver 2
Gene Name PTP4A2
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.
GO Classification
Biological Process
peptidyl-tyrosine dephosphorylation
Cellular Component
cytoplasm
plasma membrane
early endosome
Function
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
Molecular Function
prenylated protein tyrosine phosphatase activity
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Early endosome
Pathways
Gene Properties
Chromosome Location 1
Locus 1p35
SNPs PTP4A2
Gene Sequence 
>504 bp
ATGAACCGTCCAGCCCCTGTGGAGATCTCCTATGAGAACATGCGTTTTCTGATAACTCAC
AACCCTACCAATGCTACTCTCAACAAGTTCACAGAGGAACTTAAGAAGTATGGAGTGACG
ACTTTGGTTCGAGTTTGTGATGCTACATATGATAAAGCTCCAGTTGAAAAAGAAGGAATC
CACGTTCTAGATTGGCCATTTGATGATGGAGCTCCACCCCCTAATCAGATAGTAGATGAT
TGGTTAAACCTGTTAAAAACCAAATTTCGTGAAGAGCCAGGTTGCTGTGTTGCAGTGCAT
TGTGTTGCAGGATTGGGAAGGGCACCTGTGCTGGTTGCACTTGCTTTGATTGAATGTGGA
ATGAAGTACGAAGATGCAGTTCAGTTTATAAGACAAAAAAGAAGGGGAGCGTTCAATTCC
AAACAGCTGCTTTATTTGGAGAAATACCGACCTAAGATGCGATTACGCTTCAGAGATACC
AATGGGCATTGCTGTGTTCAGTAG
Protein Properties
Number of Residues 167
Molecular Weight 16366.775
Theoretical pI 8.652
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Protein tyrosine phosphatase type IVA 2
MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGI
HVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECG
MKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q12974
UniProtKB/Swiss-Prot Entry Name TP4A2_HUMAN
PDB IDs Not Available
GenBank Gene ID U14603
GeneCard ID PTP4A2
GenAtlas ID PTP4A2
HGNC ID HGNC:9635
References
General References Not Available