Showing Protein Protein tyrosine phosphatase type IVA 1 (CDBP04167)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP04167
Secondary Accession Numbers Not Available
Name Protein tyrosine phosphatase type IVA 1
Description Not Available
Synonyms
  1. PRL-1
  2. PTP(CAAXI)
  3. Protein-tyrosine phosphatase 4a1
  4. Protein-tyrosine phosphatase of regenerating liver 1
Gene Name PTP4A1
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
GO Classification
Biological Process
multicellular organismal development
cell cycle
positive regulation of cell migration
Cellular Component
spindle
cytoplasm
endoplasmic reticulum
nucleus
early endosome
internal side of plasma membrane
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
Molecular Function
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Cytoplasm
  4. Endoplasmic reticulum
  5. cytoskeleton
  6. spindle
  7. Early endosome
Pathways
Gene Properties
Chromosome Location 6
Locus 6q12
SNPs PTP4A1
Gene Sequence 
>522 bp
ATGGCTCGAATGAACCGCCCAGCTCCTGTGGAAGTCACATACAAGAACATGAGATTTCTT
ATTACACACAATCCAACCAATGCGACCTTAAACAAATTTATAGAGGAACTTAAGAAGTAT
GGAGTTACCACAATAGTAAGAGTATGTGAAGCAACTTATGACACTACTCTTGTGGAGAAA
GAAGGTATCCATGTTCTTGATTGGCCTTTTGATGATGGTGCACCACCATCCAACCAGATT
GTTGATGACTGGTTAAGTCTTGTGAAAATTAAGTTTCGTGAAGAACCTGGTTGTTGTATT
GCTGTTCATTGCGTTGCAGGCCTTGGGAGAGCTCCAGTACTTGTTGCCCTAGCATTAATT
GAAGGTGGAATGAAATACGAAGATGCAGTACAATTCATAAGACAAAAGCGGCGTGGAGCT
TTTAACAGCAAGCAACTTCTGTATTTGGAGAAGTATCGTCCTAAAATGCGGCTGCGTTTC
AAAGATTCCAACGGTCATAGAAACAACTGTTGCATTCAATAA
Protein Properties
Number of Residues 173
Molecular Weight 19814.93
Theoretical pI 8.969
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Protein tyrosine phosphatase type IVA 1
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEK
EGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI
EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q93096
UniProtKB/Swiss-Prot Entry Name TP4A1_HUMAN
PDB IDs
GenBank Gene ID U48296
GeneCard ID PTP4A1
GenAtlas ID PTP4A1
HGNC ID HGNC:9634
References
General References Not Available