| Identification |
|---|
| HMDB Protein ID
| CDBP04165 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protein phosphatase Slingshot homolog 1 |
| Description
| Not Available |
| Synonyms
|
- SSH-1L
- SSH-like protein 1
- hSSH-1L
|
| Gene Name
| SSH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
|
| GO Classification
|
| Biological Process |
| regulation of cellular protein metabolic process |
| regulation of lamellipodium assembly |
| cell morphogenesis |
| cellular response to ATP |
| actin cytoskeleton organization |
| peptidyl-tyrosine dephosphorylation |
| regulation of axonogenesis |
| regulation of actin polymerization or depolymerization |
| Cellular Component |
| cytoskeleton |
| cytoplasm |
| plasma membrane |
| cleavage furrow |
| lamellipodium |
| midbody |
| Function |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| protein tyrosine/serine/threonine phosphatase activity |
| actin binding |
| DNA binding |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
- Cell projection
- Cleavage furrow
- lamellipodium
- Midbody
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Regulation of actin cytoskeleton | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.11 |
| SNPs
| SSH1 |
| Gene Sequence
|
>3150 bp
ATGGCCCTGGTGACCCTGCAGCGCTCGCCCACGCCCAGCGCCGCCTCCTCCTCGGCCAGC
AACAGCGAGTTGGAGGCTGGCAGCGAAGAAGATCGAAAATTAAACCTCAGCTTAAGTGAG
AGCTTTTTCATGGTGAAAGGCGCAGCCCTCTTCTTACAACAGGGAAGCAGCCCTCAAGGC
CAGCGGAGTCTTCAGCACCCCCACAAGCATGCAGGTGATCTGCCTCAACATCTTCAGGTG
ATGATCAACCTTCTGCGTTGCGAAGACAGAATCAAGCTGGCAGTGCGCCTGGAGAGCGCC
TGGGCGGACCGGGTCCGGTACATGGTGGTGGTGTACAGCAGCGGGCGCCAGGACACCGAG
GAGAATATCTTGCTGGGAGTGGACTTTTCCAGTAAGGAAAGTAAAAGCTGCACCATTGGG
ATGGTTCTCCGACTGTGGAGCGACACGAAAATCCACCTTGATGGAGATGGTGGGTTCAGC
GTGAGCACAGCAGGAAGGATGCACATATTTAAGCCTGTGTCTGTCCAGGCCATGTGGTCT
GCCCTGCAGGTGCTTCACAAGGCCTGCGAAGTGGCCCGGAGGCACAACTACTTCCCCGGG
GGTGTAGCTCTCATCTGGGCTACCTACTATGAGAGCTGCATCAGCTCCGAGCAGAGCTGC
ATCAACGAGTGGAACGCCATGCAGGACCTGGAGTCTACGCGGCCCGACTCCCCCGCGCTA
TTTGTGGACAAGCCCACTGAAGGGGAAAGGACCGAGCGCCTCATCAAAGCCAAGCTCCGA
AGCATCATGATGAGCCAGGATCTAGAAAATGTGACTTCCAAAGAGATTCGTAATGAATTA
GAGAAACAGATGAATTGTAACTTGAAGGAACTCAAGGAATTTATAGACAATGAGATGCTA
CTTATCTTGGGACAGATGGACAAGCCCTCCCTTATCTTCGATCATCTTTATCTCGGCTCT
GAATGGAATGCATCCAATCTGGAGGAACTGCAGGGCTCAGGGGTTGATTACATTTTAAAT
GTTACCAGAGAAATCGATAATTTTTTTCCTGGCTTATTTGCATATCATAACATCCGAGTC
TACGATGAAGAGACCACAGACCTCCTCGCCCACTGGAATGAAGCGTATCATTTTATAAAC
AAAGCGAAGAGGAACCATTCCAAGTGCCTGGTGCATTGCAAAATGGGCGTGAGTCGCTCG
GCCTCCACAGTCATAGCCTATGCAATGAAGGAATTCGGCTGGCCTCTGGAAAAAGCATAT
AACTATGTAAAGCAGAAGCGCAGCATCACGCGCCCCAACGCGGGCTTTATGAGGCAGCTG
TCTGAGTATGAAGGCATCTTGGATGCAAGCAAACAGCGGCACAACAAGCTGTGGCGTCAG
CAGACAGACAGCAGCCTCCAGCAGCCTGTGGATGACCCTGCAGGACCTGGCGACTTCTTG
CCAGAGACCCCAGATGGCACCCCGGAAAGCCAGCTGCCCTTCTTGGATGATGCCGCCCAG
CCCGGCTTAGGGCCCCCCCTCCCCTGCTGTTTCCGGCGACTCTCAGACCCCCTTCTGCCT
TCCCCTGAGGATGAAACTGGCAGCTTGGTCCACCTGGAGGATCCGGAGAGGGAGGCTCTG
TTGGAGGAAGCTGCTCCACCTGCAGAGGTGCACAGGCCGGCCAGACAGCCCCAGCAAGGT
TCCGGACTCTGTGAGAAGGATGTGAAGAAGAAACTAGAGTTTGGGAGTCCCAAAGGTCGG
AGCGGCTCCTTGCTGCAGGTGGAGGAGACGGAAAGGGAGGAGGGCCTGGGAGCAGGGAGG
TGGGGGCAGCTTCCAACCCAGCTCGATCAAAACCTGCTCAACTCGGAGAACCTAAACAAC
AACAGCAAGAGGAGCTGTCCCAACGGCATGGAGGATGATGCTATATTTGGGATCCTTAAC
AAAGTGAAGCCTTCCTATAAATCCTGTGCCGACTGCATGTACCCTACAGCCAGCGGGGCT
CCTGAGGCCTCCAGGGAGCGATGTGAGGACCCCAATGCTCCCGCCATCTGCACCCAGCCA
GCCTTCCTACCCCACATCACGTCCTCCCCTGTGGCCCACTTGGCCAGCAGGTCCCGTGTT
CCGGAGAAGCCAGCCTCTGGCCCAACCGAACCTCCCCCGTTCCTACCACCAGCAGGCTCC
AGGAGGGCAGACACCAGTGGCCCTGGGGCTGGAGCTGCCCTAGAGCCACCAGCCAGCCTT
TTGGAACCTTCCAGAGAGACCCCAAAAGTCCTGCCAAAGTCCCTCCTTTTGAAGAATTCT
CACTGTGATAAGAACCCTCCCAGCACAGAAGTGGTAATAAAGGAAGAATCGTCACCCAAG
AAAGATATGAAGCCAGCCAAGGACCTGAGGCTTCTGTTCAGTAATGAATCTGAGAAGCCG
ACAACCAACAGCTACCTGATGCAGCACCAGGAGTCCATCATTCAGCTGCAGAAGGCAGGC
TTGGTCCGCAAGCACACCAAAGAGCTAGAGCGGCTGAAGAGCGTGCCTGCAGACCCAGCA
CCTCCCTCCAGGGATGGCCCTGCCAGCAGGCTGGAGGCCAGCATCCCCGAGGAGAGCCAG
GATCCAGCCGCGCTCCACGAGCTGGGCCCCCTGGTTATGCCCAGCCAGGCCGGGAGTGAT
GAGAAGTCAGAGGCCGCCCCCGCTTCATTGGAAGGAGGCTCACTGAAGAGCCCCCCTCCT
TTCTTCTACCGCCTGGACCACACCAGTAGTTTCTCAAAAGACTTTCTGAAGACCATCTGC
TACACCCCCACCTCCTCTTCCATGAGCTCCAACCTGACCCGGAGCTCCAGCAGCGATAGC
ATCCACAGTGTCCGTGGGAAGCCCGGGCTGGTGAAGCAGCGGACACAGGAGATTGAGACC
CGGCTCCGGCTGGCGGGCCTCACCGTCTCTTCCCCACTGAAGCGCTCACACTCTCTTGCC
AAGCTGGGGAGTCTCACCTTCTCAACGGAAGACCTGTCCAGTGAGGCTGACCCGTCCACC
GTCGCTGACTCCCAGGACACCACTTTGAGTGAATCTTCCTTCTTGCATGAGCCCCAGGGA
ACCCCGAGGGACCCAGCTGCAACCTCCAAACCATCAGGGAAACCCGCCCCAGAAAACTTA
AAGAGCCCTTCGTGGATGAGCAAAAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1049 |
| Molecular Weight
| 77429.595 |
| Theoretical pI
| 6.128 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein phosphatase Slingshot homolog 1
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQG
QRSLQHPHKHAGDLPQHLQVMINLLRCEDRIKLAVRLESAWADRVRYMVVVYSSGRQDTE
ENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPAL
FVDKPTEGERTERLIKAKLRSIMMSQDLENVTSKEIRNELEKQMNCNLKELKEFIDNEML
LILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAY
NYVKQKRSITRPNAGFMRQLSEYEGILDASKQRHNKLWRQQTDSSLQQPVDDPAGPGDFL
PETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGR
WGQLPTQLDQNLLNSENLNNNSKRSCPNGMEDDAIFGILNKVKPSYKSCADCMYPTASGA
PEASRERCEDPNAPAICTQPAFLPHITSSPVAHLASRSRVPEKPASGPTEPPPFLPPAGS
RRADTSGPGAGAALEPPASLLEPSRETPKVLPKSLLLKNSHCDKNPPSTEVVIKEESSPK
KDMKPAKDLRLLFSNESEKPTTNSYLMQHQESIIQLQKAGLVRKHTKELERLKSVPADPA
PPSRDGPASRLEASIPEESQDPAALHELGPLVMPSQAGSDEKSEAAPASLEGGSLKSPPP
FFYRLDHTSSFSKDFLKTICYTPTSSSMSSNLTRSSSSDSIHSVRGKPGLVKQRTQEIET
RLRLAGLTVSSPLKRSHSLAKLGSLTFSTEDLSSEADPSTVADSQDTTLSESSFLHEPQG
TPRDPAATSKPSGKPAPENLKSPSWMSKS
|
| External Links |
|---|
| GenBank ID Protein
| 239047414 |
| UniProtKB/Swiss-Prot ID
| Q8WYL5 |
| UniProtKB/Swiss-Prot Entry Name
| SSH1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018984.3 |
| GeneCard ID
| SSH1 |
| GenAtlas ID
| SSH1 |
| HGNC ID
| HGNC:30579 |
| References |
|---|
| General References
| Not Available |