Identification
HMDB Protein ID CDBP04161
Secondary Accession Numbers Not Available
Name Receptor-type tyrosine-protein phosphatase U
Description Not Available
Synonyms
  1. PCP-2
  2. PTP pi
  3. PTP-J
  4. PTP-RO
  5. Pancreatic carcinoma phosphatase 2
  6. Protein-tyrosine phosphatase J
  7. Protein-tyrosine phosphatase pi
  8. Protein-tyrosine phosphatase receptor omicron
  9. R-PTP-U
  10. R-PTP-psi
  11. Receptor-type protein-tyrosine phosphatase psi
  12. hPTP-J
Gene Name PTPRU
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
GO Classification
Biological Process
homotypic cell-cell adhesion
transmembrane receptor protein tyrosine phosphatase signaling pathway
canonical Wnt receptor signaling pathway
protein localization to cell surface
cell differentiation
negative regulation of cell migration
cell-cell adhesion
negative regulation of cell proliferation
Cellular Component
cell-cell junction
integral to plasma membrane
Component
cell part
membrane
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
transmembrane receptor protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
  3. Cell junction
Pathways
Gene Properties
Chromosome Location 1
Locus 1p35.3
SNPs PTPRU
Gene Sequence
>4341 bp
ATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACC
GAGACTCCGGCAGCTGGCTGCACCTTCGAGGAGGCAAGTGACCCAGCAGTGCCCTGCGAG
TACAGCCAGGCCCAGTACGATGACTTCCAGTGGGAGCAAGTGCGAATCCACCCTGGCACC
CGGGCACCTGCGGACCTGCCCCACGGCTCCTACTTGATGGTCAACACTTCCCAGCATGCC
CCAGGCCAGCGAGCCCATGTCATCTTCCAGAGCCTGAGCGAGAATGATACCCACTGTGTG
CAGTTCAGCTACTTCCTGTACAGCCGGGACGGGCACAGCCCGGGCACCCTGGGCGTCTAC
GTGCGCGTTAATGGGGGCCCCCTGGGCAGTGCTGTGTGGAATATGACTGGATCCCACGGC
CGTCAGTGGCACCAGGCTGAGCTGGCTGTCAGCACTTTCTGGCCCAATGAATATCAGGTG
CTGTTTGAGGCCCTCATCTCCCCAGACCGCAGGGGCTACATGGGCCTAGATGACATCCTG
CTTCTCAGCTACCCCTGCGCAAAGGCCCCACACTTCTCCCGCCTGGGCGACGTGGAGGTC
AACGCGGGCCAGAACGCGTCGTTCCAGTGCATGGCCGCGGGCAGAGCGGCCGAGGCCGAA
CGCTTCCTCTTGCAACGGCAGAGCGGGGCGCTGGTGCCGGCGGCGGGCGTGCGGCACATC
AGCCACCGGCGCTTCCTGGCCACTTTCCCGCTGGCTGCCGTGAGCCGCGCCGAGCAGGAC
CTGTACCGCTGTGTGTCCCAGGCCCCGCGCGGCGCGGGCGTCTCTAACTTCGCGGAGCTC
ATCGTCAAGGAGCCCCCAACTCCCATCGCGCCCCCACAGCTGCTGCGTGCTGGCCCCACC
TACCTCATCATCCAGCTCAACACCAACTCCATCATTGGCGACGGGCCGATCGTGCGCAAG
GAGATTGAGTACCGCATGGCGCGCGGGCCCTGGGCTGAGGTGCACGCCGTCAGCCTGCAG
ACCTACAAGCTGTGGCACCTCGACCCCGACACAGAGTATGAGATCAGCGTGCTGCTCACG
CGTCCCGGAGACGGCGGCACTGGCCGCCCTGGGCCACCCCTCATCAGCCGCACCAAATGC
GCAGAGCCCATGAGGGCCCCCAAAGGCCTGGCTTTTGCTGAGATCCAGGCCCGTCAGCTG
ACCCTGCAGTGGGAACCACTGGGCTACAACGTGACGCGTTGCCACACCTATACTGTGTCG
CTGTGCTATCACTACACCCTGGGCAGCAGCCACAACCAGACCATCCGAGAGTGTGTGAAG
ACAGAGCAAGGTGTCAGCCGCTACACCATCAAGAACCTGCTGCCCTATCGGAACGTTCAC
GTGAGGCTTGTCCTCACTAACCCTGAGGGGCGCAAAGAGGGCAAGGAGGTCACTTTCCAG
ACGGATGAGGATGTGCCCAGTGGGATTGCAGCCGAGTCCCTGACCTTCACTCCACTGGAG
GACATGATCTTCCTCAAGTGGGAGGAGCCCCAGGAGCCCAATGGTCTCATCACCCAGTAT
GAGATCAGCTACCAGAGCATCGAGTCATCAGACCCGGCAGTGAACGTGCCAGGCCCACGA
CGTACCATCTCCAAGCTCCGCAATGAGACCTACCATGTCTTCTCCAACCTGCACCCAGGC
ACCACCTACCTGTTCTCCGTGCGGGCCCGCACAGGCAAAGGCTTCGGCCAGGCGGCACTC
ACTGAGATAACCACTAACATCTCTGCTCCCAGCTTTGATTATGCCGACATGCCGTCACCC
CTGGGCGAGTCTGAGAACACCATCACCGTGCTGCTGAGGCCGGCACAGGGCCGCGGTGCG
CCCATCAGTGTGTACCAGGTGATTGTGGAGGAGGAGCGGGCGCGGAGGCTGCGGCGGGAG
CCAGGTGGACAGGACTGCTTCCCAGTGCCATTGACCTTCGAGGCGGCGCTGGCCCGAGGC
CTGGTGCACTACTTCGGGGCCGAACTGGCGGCCAGCAGTCTACCTGAGGCCATGCCCTTT
ACCGTGGGTGACAACCAGACCTACCGAGGCTTCTGGAACCCACCACTTGAGCCTAGGAAG
GCCTATCTCATCTACTTCCAGGCAGCAAGCCACCTGAAGGGGGAGACCCGGCTGAATTGC
ATCCGCATTGCCAGGAAAGCTGCCTGCAAGGAAAGCAAGCGGCCCCTGGAGGTGTCCCAG
AGATCGGAGGAGATGGGGCTTATCCTGGGCATCTGTGCAGGGGGGCTTGCTGTCCTCATC
CTTCTCCTGGGTGCCATCATTGTCATCATCCGCAAAGGGAGAGACCACTATGCCTACTCC
TACTACCCGAAGCCGGTGAACATGACCAAGGCCACCGTCAACTACCGCCAGGAGAAGACA
CACATGATGAGCGCCGTGGACCGCAGCTTCACAGACCAGAGCACCCTGCAGGAGGACGAG
CGGCTGGGCCTGTCCTTCATGGACACCCATGGCTACAGCACCCGGGGAGACCAGCGCAGC
GGTGGGGTCACTGAGGCCAGCAGCCTCCTGGGGGGCTCCCCGAGGCGTCCCTGTGGCCGG
AAGGGCTCCCCATACCACACGGGGCAGCTGCACCCTGCGGTGCGTGTCGCAGACCTTCTG
CAGCACATCAACCAGATGAAGACGGCCGAGGGTTACGGCTTCAAGCAGGAGTATGAGAGC
TTCTTTGAAGGCTGGGACGCCACAAAGAAGAAAGACAAGGTCAAGGGCAGCCGGCAGGAG
CCAATGCCTGCCTATGATCGGCACCGAGTGAAACTGCACCCGATGCTGGGAGACCCCAAT
GCCGACTACATTAATGCCAACTACATAGATGGTTACCACAGGTCAAACCACTTCATAGCC
ACTCAAGGGCCGAAGCCTGAGATGGTCTATGACTTCTGGCGTATGGTGTGGCAGGAGCAC
TGTTCCAGCATCGTCATGATCACCAAGCTGGTCGAGGTGGGCAGGGTGAAATGCTCACGG
TACTGGCCGGAGGACTCAGACACCTACGGGGACATCAAGATTATGCTGGTGAAGACAGAG
ACCCTGGCTGAGTATGTCGTGCGCACTTTTGCCCTGGAGCGGAGAGGCTACTCTGCCCGG
CACGAGGTCCGCCAGTTCCACTTCACAGCGTGGCCAGAGCATGGCGTCCCCTACCATGCC
ACGGGGCTGCTGGCTTTCATCCGGCGCGTGAAGGCCTCCACCCCACCTGATGCCGGGCCC
ATTGTCATCCACTGCAGCGCGGGCACCGGCCGCACAGGTTGCTATATCGTCCTGGATGTG
ATGCTGGACATGGCAGAGTGTGAGGGCGTCGTGGACATTTACAACTGTGTGAAGACTCTC
TGCTCCCGGCGTGTCAACATGATCCAGACTGAGGAGCAGTACATCTTCATTCATGATGCA
ATCCTGGAGGCCTGCCTGTGTGGGGAGACCACCATCCCTGTCAGTGAGTTCAAGGCCACC
TACAAGGAGATGATCCGCATTGATCCTCAGAGTAATTCCTCCCAGCTGCGGGAAGAGTTC
CAGACGCTGAACTCGGTCACCCCGCCGCTGGACGTGGAGGAGTGCAGCATCGCCCTGTTG
CCCCGGAACCGCGACAAGAACCGCAGCATGGACGTCCTGCCGCCCGACCGCTGCCTGCCC
TTCCTCATCTCCACTGATGGGGACTCCAACAACTACATTAATGCAGCCCTGACTGACAGC
TACACACGGAGTGCGGCCTTCATCGTGACCCTGCACCCGCTGCAGAGCACCACGCCCGAC
TTCTGGCGGCTGGTCTACGATTACGGGTGCACCTCCATCGTCATGCTCAACCAGCTGAAC
CAGTCCAACTCCGCCTGGCCCTGCCTGCAGTACTGGCCAGAGCCAGGCCGGCAGCAATAT
GGCCTCATGGAGGTGGAGTTTATGTCGGGCACAGCTGATGAAGACTTAGTGGCTCGAGTC
TTCCGGGTGCAGAACATCTCTCGGTTGCAGGAGGGGCACCTGCTGGTGCGGCACTTCCAG
TTCCTGCGCTGGTCTGCATACCGGGACACACCTGACTCCAAGAAGGCCTTCTTGCACCTG
CTGGCTGAGGTGGACAAGTGGCAGGCCGAGAGTGGGGATGGGCGCACCATCGTGCACTGC
CTAAACGGGGGAGGACGCAGCGGCACCTTCTGCGCCTGCGCCACGGTCCTGGAGATGATC
CGCTGCCACAACTTGGTGGACGTTTTCTTTGCTGCCAAAACCCTCCGGAACTACAAACCC
AACATGGTGGAGACCATGGATCAGTACCACTTTTGCTACGATGTGGCCCTGGAGTACTTG
GAGGGGCTGGAGTCAAGATAG
Protein Properties
Number of Residues 1446
Molecular Weight 160793.34
Theoretical pI 6.861
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Receptor-type tyrosine-protein phosphatase U
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS
YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
EGLESR
GenBank ID Protein 110735402
UniProtKB/Swiss-Prot ID Q92729
UniProtKB/Swiss-Prot Entry Name PTPRU_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005704.4
GeneCard ID PTPRU
GenAtlas ID PTPRU
HGNC ID HGNC:9683
References
General References Not Available