| Identification |
|---|
| HMDB Protein ID
| CDBP04161 |
| Secondary Accession Numbers
| Not Available |
| Name
| Receptor-type tyrosine-protein phosphatase U |
| Description
| Not Available |
| Synonyms
|
- PCP-2
- PTP pi
- PTP-J
- PTP-RO
- Pancreatic carcinoma phosphatase 2
- Protein-tyrosine phosphatase J
- Protein-tyrosine phosphatase pi
- Protein-tyrosine phosphatase receptor omicron
- R-PTP-U
- R-PTP-psi
- Receptor-type protein-tyrosine phosphatase psi
- hPTP-J
|
| Gene Name
| PTPRU |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
|
| GO Classification
|
| Biological Process |
| homotypic cell-cell adhesion |
| transmembrane receptor protein tyrosine phosphatase signaling pathway |
| canonical Wnt receptor signaling pathway |
| protein localization to cell surface |
| cell differentiation |
| negative regulation of cell migration |
| cell-cell adhesion |
| negative regulation of cell proliferation |
| Cellular Component |
| cell-cell junction |
| integral to plasma membrane |
| Component |
| cell part |
| membrane |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| transmembrane receptor protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p35.3 |
| SNPs
| PTPRU |
| Gene Sequence
|
>4341 bp
ATGGCCCGTGCCCAGGCGCTCGTGCTGGCACTCACCTTCCAGCTCTGCGCGCCGGAGACC
GAGACTCCGGCAGCTGGCTGCACCTTCGAGGAGGCAAGTGACCCAGCAGTGCCCTGCGAG
TACAGCCAGGCCCAGTACGATGACTTCCAGTGGGAGCAAGTGCGAATCCACCCTGGCACC
CGGGCACCTGCGGACCTGCCCCACGGCTCCTACTTGATGGTCAACACTTCCCAGCATGCC
CCAGGCCAGCGAGCCCATGTCATCTTCCAGAGCCTGAGCGAGAATGATACCCACTGTGTG
CAGTTCAGCTACTTCCTGTACAGCCGGGACGGGCACAGCCCGGGCACCCTGGGCGTCTAC
GTGCGCGTTAATGGGGGCCCCCTGGGCAGTGCTGTGTGGAATATGACTGGATCCCACGGC
CGTCAGTGGCACCAGGCTGAGCTGGCTGTCAGCACTTTCTGGCCCAATGAATATCAGGTG
CTGTTTGAGGCCCTCATCTCCCCAGACCGCAGGGGCTACATGGGCCTAGATGACATCCTG
CTTCTCAGCTACCCCTGCGCAAAGGCCCCACACTTCTCCCGCCTGGGCGACGTGGAGGTC
AACGCGGGCCAGAACGCGTCGTTCCAGTGCATGGCCGCGGGCAGAGCGGCCGAGGCCGAA
CGCTTCCTCTTGCAACGGCAGAGCGGGGCGCTGGTGCCGGCGGCGGGCGTGCGGCACATC
AGCCACCGGCGCTTCCTGGCCACTTTCCCGCTGGCTGCCGTGAGCCGCGCCGAGCAGGAC
CTGTACCGCTGTGTGTCCCAGGCCCCGCGCGGCGCGGGCGTCTCTAACTTCGCGGAGCTC
ATCGTCAAGGAGCCCCCAACTCCCATCGCGCCCCCACAGCTGCTGCGTGCTGGCCCCACC
TACCTCATCATCCAGCTCAACACCAACTCCATCATTGGCGACGGGCCGATCGTGCGCAAG
GAGATTGAGTACCGCATGGCGCGCGGGCCCTGGGCTGAGGTGCACGCCGTCAGCCTGCAG
ACCTACAAGCTGTGGCACCTCGACCCCGACACAGAGTATGAGATCAGCGTGCTGCTCACG
CGTCCCGGAGACGGCGGCACTGGCCGCCCTGGGCCACCCCTCATCAGCCGCACCAAATGC
GCAGAGCCCATGAGGGCCCCCAAAGGCCTGGCTTTTGCTGAGATCCAGGCCCGTCAGCTG
ACCCTGCAGTGGGAACCACTGGGCTACAACGTGACGCGTTGCCACACCTATACTGTGTCG
CTGTGCTATCACTACACCCTGGGCAGCAGCCACAACCAGACCATCCGAGAGTGTGTGAAG
ACAGAGCAAGGTGTCAGCCGCTACACCATCAAGAACCTGCTGCCCTATCGGAACGTTCAC
GTGAGGCTTGTCCTCACTAACCCTGAGGGGCGCAAAGAGGGCAAGGAGGTCACTTTCCAG
ACGGATGAGGATGTGCCCAGTGGGATTGCAGCCGAGTCCCTGACCTTCACTCCACTGGAG
GACATGATCTTCCTCAAGTGGGAGGAGCCCCAGGAGCCCAATGGTCTCATCACCCAGTAT
GAGATCAGCTACCAGAGCATCGAGTCATCAGACCCGGCAGTGAACGTGCCAGGCCCACGA
CGTACCATCTCCAAGCTCCGCAATGAGACCTACCATGTCTTCTCCAACCTGCACCCAGGC
ACCACCTACCTGTTCTCCGTGCGGGCCCGCACAGGCAAAGGCTTCGGCCAGGCGGCACTC
ACTGAGATAACCACTAACATCTCTGCTCCCAGCTTTGATTATGCCGACATGCCGTCACCC
CTGGGCGAGTCTGAGAACACCATCACCGTGCTGCTGAGGCCGGCACAGGGCCGCGGTGCG
CCCATCAGTGTGTACCAGGTGATTGTGGAGGAGGAGCGGGCGCGGAGGCTGCGGCGGGAG
CCAGGTGGACAGGACTGCTTCCCAGTGCCATTGACCTTCGAGGCGGCGCTGGCCCGAGGC
CTGGTGCACTACTTCGGGGCCGAACTGGCGGCCAGCAGTCTACCTGAGGCCATGCCCTTT
ACCGTGGGTGACAACCAGACCTACCGAGGCTTCTGGAACCCACCACTTGAGCCTAGGAAG
GCCTATCTCATCTACTTCCAGGCAGCAAGCCACCTGAAGGGGGAGACCCGGCTGAATTGC
ATCCGCATTGCCAGGAAAGCTGCCTGCAAGGAAAGCAAGCGGCCCCTGGAGGTGTCCCAG
AGATCGGAGGAGATGGGGCTTATCCTGGGCATCTGTGCAGGGGGGCTTGCTGTCCTCATC
CTTCTCCTGGGTGCCATCATTGTCATCATCCGCAAAGGGAGAGACCACTATGCCTACTCC
TACTACCCGAAGCCGGTGAACATGACCAAGGCCACCGTCAACTACCGCCAGGAGAAGACA
CACATGATGAGCGCCGTGGACCGCAGCTTCACAGACCAGAGCACCCTGCAGGAGGACGAG
CGGCTGGGCCTGTCCTTCATGGACACCCATGGCTACAGCACCCGGGGAGACCAGCGCAGC
GGTGGGGTCACTGAGGCCAGCAGCCTCCTGGGGGGCTCCCCGAGGCGTCCCTGTGGCCGG
AAGGGCTCCCCATACCACACGGGGCAGCTGCACCCTGCGGTGCGTGTCGCAGACCTTCTG
CAGCACATCAACCAGATGAAGACGGCCGAGGGTTACGGCTTCAAGCAGGAGTATGAGAGC
TTCTTTGAAGGCTGGGACGCCACAAAGAAGAAAGACAAGGTCAAGGGCAGCCGGCAGGAG
CCAATGCCTGCCTATGATCGGCACCGAGTGAAACTGCACCCGATGCTGGGAGACCCCAAT
GCCGACTACATTAATGCCAACTACATAGATGGTTACCACAGGTCAAACCACTTCATAGCC
ACTCAAGGGCCGAAGCCTGAGATGGTCTATGACTTCTGGCGTATGGTGTGGCAGGAGCAC
TGTTCCAGCATCGTCATGATCACCAAGCTGGTCGAGGTGGGCAGGGTGAAATGCTCACGG
TACTGGCCGGAGGACTCAGACACCTACGGGGACATCAAGATTATGCTGGTGAAGACAGAG
ACCCTGGCTGAGTATGTCGTGCGCACTTTTGCCCTGGAGCGGAGAGGCTACTCTGCCCGG
CACGAGGTCCGCCAGTTCCACTTCACAGCGTGGCCAGAGCATGGCGTCCCCTACCATGCC
ACGGGGCTGCTGGCTTTCATCCGGCGCGTGAAGGCCTCCACCCCACCTGATGCCGGGCCC
ATTGTCATCCACTGCAGCGCGGGCACCGGCCGCACAGGTTGCTATATCGTCCTGGATGTG
ATGCTGGACATGGCAGAGTGTGAGGGCGTCGTGGACATTTACAACTGTGTGAAGACTCTC
TGCTCCCGGCGTGTCAACATGATCCAGACTGAGGAGCAGTACATCTTCATTCATGATGCA
ATCCTGGAGGCCTGCCTGTGTGGGGAGACCACCATCCCTGTCAGTGAGTTCAAGGCCACC
TACAAGGAGATGATCCGCATTGATCCTCAGAGTAATTCCTCCCAGCTGCGGGAAGAGTTC
CAGACGCTGAACTCGGTCACCCCGCCGCTGGACGTGGAGGAGTGCAGCATCGCCCTGTTG
CCCCGGAACCGCGACAAGAACCGCAGCATGGACGTCCTGCCGCCCGACCGCTGCCTGCCC
TTCCTCATCTCCACTGATGGGGACTCCAACAACTACATTAATGCAGCCCTGACTGACAGC
TACACACGGAGTGCGGCCTTCATCGTGACCCTGCACCCGCTGCAGAGCACCACGCCCGAC
TTCTGGCGGCTGGTCTACGATTACGGGTGCACCTCCATCGTCATGCTCAACCAGCTGAAC
CAGTCCAACTCCGCCTGGCCCTGCCTGCAGTACTGGCCAGAGCCAGGCCGGCAGCAATAT
GGCCTCATGGAGGTGGAGTTTATGTCGGGCACAGCTGATGAAGACTTAGTGGCTCGAGTC
TTCCGGGTGCAGAACATCTCTCGGTTGCAGGAGGGGCACCTGCTGGTGCGGCACTTCCAG
TTCCTGCGCTGGTCTGCATACCGGGACACACCTGACTCCAAGAAGGCCTTCTTGCACCTG
CTGGCTGAGGTGGACAAGTGGCAGGCCGAGAGTGGGGATGGGCGCACCATCGTGCACTGC
CTAAACGGGGGAGGACGCAGCGGCACCTTCTGCGCCTGCGCCACGGTCCTGGAGATGATC
CGCTGCCACAACTTGGTGGACGTTTTCTTTGCTGCCAAAACCCTCCGGAACTACAAACCC
AACATGGTGGAGACCATGGATCAGTACCACTTTTGCTACGATGTGGCCCTGGAGTACTTG
GAGGGGCTGGAGTCAAGATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1446 |
| Molecular Weight
| 160793.34 |
| Theoretical pI
| 6.861 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase U
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGT
RAPADLPHGSYLMVNTSQHAPGQRAHVIFQSLSENDTHCVQFSYFLYSRDGHSPGTLGVY
VRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHI
SHRRFLATFPLAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPT
YLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVS
LCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQ
TDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPR
RTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSP
LGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAALARG
LVHYFGAELAASSLPEAMPFTVGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNC
IRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAVLILLLGAIIVIIRKGRDHYAYS
YYPKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMDTHGYSTRGDQRS
GGVTEASSLLGGSPRRPCGRKGSPYHTGQLHPAVRVADLLQHINQMKTAEGYGFKQEYES
FFEGWDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDGYHRSNHFIA
TQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSDTYGDIKIMLVKTE
TLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGP
IVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDA
ILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALL
PRNRDKNRSMDVLPPDRCLPFLISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPD
FWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARV
FRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHC
LNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL
EGLESR
|
| External Links |
|---|
| GenBank ID Protein
| 110735402 |
| UniProtKB/Swiss-Prot ID
| Q92729 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRU_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005704.4 |
| GeneCard ID
| PTPRU |
| GenAtlas ID
| PTPRU |
| HGNC ID
| HGNC:9683 |
| References |
|---|
| General References
| Not Available |