| Identification |
|---|
| HMDB Protein ID
| CDBP04160 |
| Secondary Accession Numbers
| Not Available |
| Name
| Receptor-type tyrosine-protein phosphatase T |
| Description
| Not Available |
| Synonyms
|
- R-PTP-T
- RPTP-rho
- Receptor-type tyrosine-protein phosphatase rho
|
| Gene Name
| PTPRT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| May be involved in both signal transduction and cellular adhesion in the CNS.
|
| GO Classification
|
| Biological Process |
| homophilic cell adhesion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| Cellular Component |
| cell surface |
| plasma membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| thiolester hydrolase activity |
| alpha-catenin binding |
| gamma-catenin binding |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 20 |
| Locus
| 20q12-q13 |
| SNPs
| PTPRT |
| Gene Sequence
|
>4392 bp
ATGGCGAGCCTCGCCGCGCTCGCCCTCAGCCTGCTCCTGAGGCTGCAGCTGCCGCCACTG
CCCGGCGCCCGGGCTCAGAGCGCCCCAGGTGGCTGTTCCTTTGATGAGCACTACAGCAAC
TGTGGTTATAGTGTGGCTCTAGGGACCAATGGGTTCACCTGGGAGCAGATTAACACAACG
GAGAAACCAATGCTGGACCAGGCAGTGCCCACAGGATCTTTCATGATGGTGAACAGCTCT
GGGAGAGCCTCTGGCCAGAAGGCCCACCTTCTCCTGCCAACCCTGAAGGAGAATGACACC
CACTGCATCGACTTCCATTACTACTTCTCCAGCCGTGACAGGTCCAGCCCAGGGGCCTTG
AACGTCTACGTGAAGGTGAATGGTGGCCCCCAAGGGAACCCTGTGTGGAATGTGTCCGGG
GTCGTCACTGAGGGCTGGGTGAAGGCAGAGCTCGCCATCAGCACTTTCTGGCCACATTTC
TATCAGGTGATATTTGAATCCGTCTCATTGAAGGGTCATCCTGGCTACATCGCCGTGGAC
GAGGTCCGGGTCCTTGCTCATCCATGCAGAAAAGCACCTCATTTTCTGCGACTCCAAAAC
GTGGAGGTGAATGTGGGGCAGAATGCCACATTTCAGTGCATTGCTGGTGGGAAGTGGTCT
CAGCATGACAAGCTTTGGCTCCAGCAATGGAATGGCAGGGACACGGCCCTGATGGTCACC
CGTGTGGTCAACCACAGGCGCTTCTCAGCCACAGTCAGTGTGGCAGACACTGCCCAGCGG
AGCGTCAGCAAGTACCGCTGTGTGATCCGCTCTGATGGTGGGTCTGGTGTGTCCAACTAC
GCGGAGCTGATCGTGAAAGAGCCTCCCACGCCCATTGCTCCCCCAGAGCTGCTGGCTGTG
GGGGCCACATACCTGTGGATCAAGCCAAATGCCAACTCCATCATCGGGGATGGCCCCATC
ATCCTGAAGGAAGTGGAATATCGCACCACCACAGGCACGTGGGCAGAGACCCACATAGTC
GACTCTCCCAACTATAAGCTGTGGCATCTGGACCCCGATGTTGAGTATGAGATCCGAGTG
CTCCTCACACGACCAGGTGAGGGGGGTACGGGACCGCCAGGGGCTCCCCTCACCACCAGG
ACCAAGTGTGCAGATCCGGTACATGGCCCACAGAACGTGGAAATCGTAGACATCAGAGCC
CGGCAGCTGACCCTGCAGTGGGAGCCCTTCGGCTACGCGGTGACCCGCTGCCATAGCTAC
AACCTCACCGTGCAGTACCAGTATGTGTTCAACCAGCAGCAGTACGAGGCCGAGGAGGTC
ATCCAGACCTCCTCCCACTACACCCTGCGAGGCCTGCGCCCCTTCATGACCATCCGGCTG
CGACTCTTGCTGTCTAACCCCGAGGGCCGAATGGAGAGCGAGGAGCTGGTGGTGCAGACT
GAGGAAGACGTTCCAGGAGCTGTTCCTCTAGAATCCATCCAAGGGGGGCCCTTTGAGGAG
AAGATCTACATCCAGTGGAAACCTCCCAATGAGACCAATGGGGTCATCACGCTCTACGAG
ATCAACTACAAGGCTGTCGGCTCGCTGGACCCAAGTGCTGACCTCTCGAGCCAGAGGGGG
AAAGTGTTCAAGCTCCGGAATGAAACCCACCACCTCTTTGTGGGTCTGTACCCAGGGACC
ACCTATTCCTTCACCATCAAGGCCAGCACAGCAAAGGGCTTTGGGCCCCCTGTCACCACT
CGGATTGCCACCAAAATTTCAGCTCCATCCATGCCTGAGTACGACACAGACACCCCATTG
AATGAGACAGACACGACCATCACAGTGATGCTGAAACCCGCTCAGTCCCGGGGAGCTCCT
GTCAGTGTTTATCAGCTGGTTGTCAAGGAGGAGCGACTTCAGAAGTCACGGAGGGCAGCT
GACATTATTGAGTGCTTTTCGGTGCCCGTGAGCTATCGGAATGCCTCCAGCCTCGATTCT
CTACACTACTTTGCTGCTGAGTTGAAGCCTGCCAACCTGCCTGTCACCCAGCCATTTACA
GTGGGTGACAATAAGACATACAATGGCTACTGGAACCCTCCTCTCTCTCCCCTGAAAAGC
TACAGCATCTACTTCCAGGCACTCAGCAAAGCCAATGGAGAGACCAAAATCAACTGTGTT
CGTCTGGCTACAAAAGCACCAATGGGCAGCGCCCAGGTGACCCCGGGGACTCCACTCTGC
CTCCTCACCACAGGTGCCTCCACCCAGAATTCTAACACTGTGGAGCCAGAGAAGCAGGTG
GACAACACCGTGAAGATGGCTGGCGTGATCGCTGGCCTCCTCATGTTCATCATCATTCTC
CTGGGCGTGATGCTCACCATCAAAAGGAGAAGAAATGCTTATTCCTACTCCTATTACTTG
TCCCAAAGGAAGCTGGCCAAGAAGCAGAAGGAGACCCAGAGTGGAGCCCAGAGGGAGATG
GGGCCTGTGGCCTCTGCCGACAAACCCACCACCAAGCTCAGCGCCAGCCGCAATGATGAA
GGCTTCTCTTCTAGTTCTCAGGACGTCAACGGATTCACAGATGGCAGCCGCGGGGAGCTT
TCCCAGCCCACCCTCACGATCCAGACTCATCCCTACCGCACCTGTGACCCTGTGGAGATG
AGCTACCCCCGGGACCAGTTCCAACTCGCCATCCGGGTGGCTGACTTGCTGCAGCACATC
ACGCAGATGAAGAGAGGCCAGGGCTACGGGTTCAAGGAGGAATACGAGGCCTTACCAGAG
GGGCAGACAGCTTCGTGGGACACAGCCAAGGAGGATGAAAACCGCAATAAGAATCGATAT
GGGAACATCATATCCTACGACCATTCCCGGGTGAGGCTGCTGGTGCTGGATGGAGACCCG
CACTCTGACTACATCAATGCCAACTACATTGACGGATACCATCGACCTCGGCACTACATT
GCGACTCAAGGTCCGATGCAGGAGACTGTAAAGGACTTTTGGAGAATGATCTGGCAGGAG
AACTCCGCCAGCATCGTCATGGTCACAAACCTGGTGGAAGTGGGCAGGGTGAAATGTGTG
CGATACTGGCCAGATGACACGGAGGTCTACGGAGACATTAAAGTCACCCTGATTGAAACA
GAGCCCCTGGCAGAATACGTCATACGCACCTTCACAGTCCAGAAGAAAGGCTACCATGAG
ATCCGGGAGCTCCGCCTCTTCCACTTCACCAGCTGGCCTGACCACGGCGTTCCCTGCTAT
GCCACTGGCCTTCTGGGCTTCGTCCGCCAGGTCAAGTTCCTCAACCCCCCGGAAGCTGGG
CCCATAGTGGTCCACTGCAGTGCTGGGGCTGGGCGGACTGGCTGCTTCATTGCCATTGAC
ACCATGCTTGACATGGCCGAGAATGAAGGGGTGGTGGACATCTTCAACTGCGTGCGTGAG
CTCCGGGCCCAAAGGGTCAACCTGGTACAGACAGAGGAGCAATATGTGTTTGTGCACGAT
GCCATCCTGGAAGCGTGCCTCTGTGGCAACACTGCCATCCCTGTGTGTGAGTTCCGTTCT
CTCTACTACAATATCAGCAGGCTGGACCCCCAGACAAACTCCAGCCAAATCAAAGATGAA
TTTCAGACCCTCAACATTGTGACACCCCGTGTGCGGCCCGAGGACTGCAGCATTGGGCTC
CTGCCCCGGAACCATGATAAGAATCGAAGTATGGACGTGCTGCCTCTGGACCGCTGCCTG
CCCTTCCTTATCTCAGTGGACGGAGAATCCAGCAATTACATCAACGCAGCACTGATGGAT
AGCCACAAGCAGCCTGCCGCCTTCGTGGTCACCCAGCACCCTCTACCCAACACCGTGGCA
GACTTCTGGAGGCTGGTGTTCGATTACAACTGCTCCTCTGTGGTGATGCTGAATGAGATG
GACACTGCCCAGTTCTGTATGCAGTACTGGCCTGAGAAGACCTCCGGGTGCTATGGGCCC
ATCCAGGTGGAGTTCGTCTCCGCAGACATCGACGAGGACATCATCCACAGAATATTCCGC
ATCTGTAACATGGCCCGGCCACAGGATGGTTATCGTATAGTCCAGCACCTCCAGTACATT
GGCTGGCCTGCCTACCGGGACACGCCCCCCTCCAAGCGCTCTCTGCTCAAAGTGGTCCGA
CGACTGGAGAAGTGGCAGGAGCAGTATGACGGGAGGGAGGGACGTACTGTGGTCCACTGC
CTAAATGGGGGAGGCCGTAGTGGAACCTTCTGTGCCATCTGCAGTGTGTGTGAGATGATC
CAGCAGCAAAACATCATTGACGTGTTCCACATCGTGAAAACACTGCGTAACAACAAATCC
AACATGGTGGAGACCCTGGAACAGTATAAATTTGTATACGAGGTGGCACTGGAATATTTA
AGCTCCTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1463 |
| Molecular Weight
| 162132.92 |
| Theoretical pI
| 6.893 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Receptor-type tyrosine-protein phosphatase T
MASLAALALSLLLRLQLPPLPGARAQSAAGGCSFDEHYSNCGYSVALGTNGFTWEQINTW
EKPMLDQAVPTGSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRSSPGAL
NVYVKVNGGPQGNPVWNVSGVVTEGWVKAELAISTFWPHFYQVIFESVSLKGHPGYIAVD
EVRVLAHPCRKAPHFLRLQNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVT
RVVNHRRFSATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPPELLAV
GATYLWIKPNANSIIGDGPIILKEVEYRTTTGTWAETHIVDSPNYKLWHLDPDVEYEIRV
LLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEPFGYAVTRCHSY
NLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQT
EEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRG
KVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFGPPVTTRIATKISAPSMPEYDTDTPL
NETDTTITVMLKPAQSRGAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDS
LHYFAAELKPANLPVTQPFTVGDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINCV
RLATKAPMGSAQVTPGTPLCLLTTGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIIL
LGVMLTIKRRRNAYSYSYYLSQRKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDE
GFSSSSQDVNGFTDGSRGELSQPTLTIQTHPYRTCDPVEMSYPRDQFQPAIRVADLLQHI
TQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDP
HSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCV
RYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCY
ATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRE
LRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDE
FQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMD
SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCYGP
IQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVR
RLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKS
NMVETLEQYKFVYEVALEYLSSF
|
| External Links |
|---|
| GenBank ID Protein
| 6554165 |
| UniProtKB/Swiss-Prot ID
| O14522 |
| UniProtKB/Swiss-Prot Entry Name
| PTPRT_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF043644 |
| GeneCard ID
| PTPRT |
| GenAtlas ID
| PTPRT |
| HGNC ID
| HGNC:9682 |
| References |
|---|
| General References
| Not Available |