Identification
HMDB Protein ID CDBP04139
Secondary Accession Numbers Not Available
Name Tyrosine-protein phosphatase non-receptor type 18
Description Not Available
Synonyms
  1. Brain-derived phosphatase
Gene Name PTPN18
Protein Type Enzyme
Biological Properties
General Function Involved in phosphatase activity
Specific Function Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
GO Classification
Cellular Component
cytoplasm
nucleus
Function
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
Molecular Function
non-membrane spanning protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location 2
Locus 2q21.1
SNPs PTPN18
Gene Sequence
>1377 bp
ATGAGCCGCAGCCTGGACTCGGCGCGGAGCTTCCTGGAGCGGCTGGAAGCGCGGGGCGGC
CGGGAGGGGGCAGTCCTCGCCGGCGAGTTCAGCGACATCCAGGCCTGCTCGGCCGCCTGG
AAGGCTGACGGCGTGTGCTCCACCGTGGCCGGCAGTCGGCCAGAGAACGTGAGGAAGAAC
CGCTACAAAGACGTGCTGCCTTATGATCAGACGCGAGTAATCCTCTCCCTGCTCCAGGAA
GAGGGACACAGCGACTACATTAATGGCAACTTCATCCGGGGCGTGGATGGAAGCCTGGCC
TACATTGCCACGCAAGGACCCTTGCCTCACACCCTGCTAGACTTCTGGAGACTGGTCTGG
GAGTTTGGGGTCAAGGTGATCCTGATGGCCTGTCGAGAGATAGAGAATGGGCGGAAAAGG
TGTGAGCGGTACTGGGCCCAGGAGCAGGAGCCACTGCAGACTGGGCTTTTCTGCATCACT
CTGATAAAGGAGAAGTGGCTGAATGAGGACATCATGCTCAGGACCCTCAAGGTCACATTC
CAGAAGGAGTCCCGTTCTGTGTACCAGCTACAGTATATGTCCTGGCCAGACCGTGGGGTC
CCCAGCAGTCCTGACCACATGCTCGCCATGGTGGAGGAAGCCCGTCGCCTCCAGGGATCT
GGCCCTGAACCCCTCTGTGTCCACTGCAGTGCGGGTTGTGGGCGAACAGGCGTCCTGTGC
ACCGTGGATTATGTGAGGCAGCTGCTCCTGACCCAGATGATCCCACCTGACTTCAGTCTC
TTTGATGTGGTCCTTAAGATGAGGAAGCAGCGGCCTGCGGCCGTGCAGACAGAGGAGCAG
TACAGGTTCCTGTACCACACGGTGGCTCAGATGTTCTGCTCCACACTCCAGAATGCCAGC
CCCCACTACCAGAACATCAAAGAGAATTGTGCCCCACTCTACGACGATGCCCTCTTCCTC
CGGACTCCCCAGGCACTTCTCGCCATACCCCGCCCACCAGGAGGGGTCCTCAGGAGCATC
TCTGTGCCCGGGTCCCCGGGCCACGCCATGGCTGACACCTACGCGGAGGAGCAGAAGCGC
GGGGCTCCAGCGGGCGCCGGGAGTGGGACGCAGACGGGGACGGGGACGGGGGCGCGCAGC
GCGGAGGAGGCGCCGCTCTACAGCAAGGTGACGCCGCGCGCCCAGCGACCCGGGGCGCAC
GCGGAGGACGCGAGGGGGACGCTGCCTGGCCGCGTTCCTGCTGACCAAAGTCCTGCCGGA
TCTGGCGCCTACGAGGACGTGGCGGGTGGAGCTCAGACCGGTGGGCTAGGTTTCAACCTG
CGCATTGGGAGGCCGAAGGGTCCCCGGGACCCGCCTGCTGAGTGGACCCGGGTGTAA
Protein Properties
Number of Residues 460
Molecular Weight 38475.43
Theoretical pI 8.591
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Tyrosine-protein phosphatase non-receptor type 18
MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKN
RYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVW
EFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTF
QKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLC
TVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNAS
PHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKR
GAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSP
AGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV
GenBank ID Protein 1871531
UniProtKB/Swiss-Prot ID Q99952
UniProtKB/Swiss-Prot Entry Name PTN18_HUMAN
PDB IDs
GenBank Gene ID X79568
GeneCard ID PTPN18
GenAtlas ID PTPN18
HGNC ID HGNC:9649
References
General References Not Available