Cannabis Compound Database: Showing Protein Myotubularin-related protein 4 (CDBP04131)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04131

Secondary Accession Numbers

Not Available

Name

Myotubularin-related protein 4

Description

Not Available

Synonyms

FYVE domain-containing dual specificity protein phosphatase 2
FYVE-DSP2
Zinc finger FYVE domain-containing protein 11

Gene Name

MTMR4

Protein Type

Enzyme

Biological Properties

General Function

Involved in phosphatase activity

Specific Function

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

GO Classification

Biological Process
small molecule metabolic process
phosphatidylinositol biosynthetic process
negative regulation of transforming growth factor beta receptor signaling pathway
transforming growth factor beta receptor signaling pathway
Cellular Component
cytosol
early endosome membrane
Function
hydrolase activity, acting on ester bonds
binding
catalytic activity
hydrolase activity
transition metal ion binding
zinc ion binding
phosphoric ester hydrolase activity
phosphatase activity
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
ion binding
cation binding
metal ion binding
Molecular Function
protein serine/threonine phosphatase activity
metal ion binding
protein tyrosine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
metabolic process
cellular metabolic process

Cellular Location

Cytoplasm
Peripheral membrane protein
Membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

17q22-q23

SNPs

MTMR4

Gene Sequence

>3588 bp
ATGGGTGAGGAGGGGCCCCCCAGCCTGGAGTACATCCAAGCCAAGGATCTGTTCCCCCCC
AAGGAACTAGTGAAGGAGGAAGAGAATCTTCAGGTCCCCTTCACAGTGCTGCAGGGTGAG
GGAGTAGAGTTCCTGGGCCGGGCAGCCGATGCCCTCATTGCCATCTCTAACTACCGGCTG
CATATCAAATTCAAGGACTCTGTCATCAACGTCCCCCTCCGGATGATTGACAGTGTGGAG
AGCCGTGATATGTTCCAGTTGCACATTTCCTGCAAGGACTCCAAAGTGGTGAGGTGCCAC
TTCTCCACTTTTAAGCAGTGCCAAGAGTGGCTCTCACGGCTAAGCCGAGCCACAGCAAGA
CCTGCCAAGCCTGAAGACCTCTTTGCCTTTGCCTACCATGCCTGGTGCCTGGGGCTGACC
GAGGAGGACCAGCACACTCACCTATGTCAGCCAGGTGAGCACATACGTTGTCGACAGGAG
GCGGAGCTTGCAAGGATGGGCTTTGACGTGCAGAACGTCTGGAGAGTCTCACACATCAAC
AGCAACTACAAATTGTGCCCCAGTTACCCCCAGAAGCTGCTGGTTCCTGTGTGGATCACT
GACAAAGAGCTGGAGAACGTGGCTTCCTTCCGCTCCTGGAAGCGGATTCCCGTGGTTGTG
TATAGACACTTGCGCAATGGGGCTGCCATCGCCCGCTGCAGCCAGCCAGAGATCAGCTGG
TGGGGCTGGCGCAATGCTGATGATGAGTACCTGGTCACGTCCATTGCTAAAGCCTGTGCC
CTGGACCCGGGGACAAGGGCCACTGGGGGCTCCCTCAGCACCGGGAATAATGATACCAGC
GAGGCGTGTGATGCTGACTTTGATTCTTCTCTGACTGCGTGCTCTGGAGTGGAGAGCACA
GCAGCTCCTCAAAAGCTGCTGATCCTGGATGCGCGATCCTACACGGCAGCAGTGGCCAAC
CGGGCCAAGGGTGGAGGCTGTGAATGTGAAGAGTACTATCCCAACTGTGAGGTCGTGTTC
ATGGGAATGGCCAACATCCATGCCATCCGGAACAGCTTTCAGTACCTCCGGGCTGTGTGT
AGCCAGATGCCGGATCCTAGCAACTGGTTGTCGGCACTGGAGAGTACCAAATGGCTGCAG
CACTTGTCGGTGATGCTAAAAGCAGCTGTGCTGGTGGCTAATACAGTAGACCGGGAAGGC
CGGCCTGTGCTGGTACACTGCTCAGATGGCTGGGACCGCACACCGCAGATCGTAGCCCTG
GCCAAAATATTACTGGACCCATATTACAGGACGTTGGAGGGCTTCCAAGTGTTAGTGGAG
TCTGACTGGCTGGATTTTGGGCACAAGTTTGGAGATCGCTGTGGCCACCAAGAGAATGTG
GAGGACCAAAACGAACAATGCCCTGTGTTCCTCCAGTGGCTTGATTCTGTTCATCAGTTG
CTTAAGCAGTTCCCCTGCCTGTTTGAATTTAATGAAGCATTCCTGGTAAAACTGGTGCAA
CACACATACTCCTGCCTCTACGGCACCTTCCTGGCCAACAACCCCTGTGAGCGAGAGAAG
CGCAACATCTACAAGCGGACCTGCTCTGTGTGGGCGCTCCTTCGAGCTGGCAATAAAAAC
TTTCATAACTTCCTCTACACACCCAGCTCAGACATGGTCCTGCATCCTGTTTGTCATGTC
CGGGCCCTGCACCTCTGGACAGCTGTTTATCTGCCAGCATCATCTCCATGCACACTTGGG
GAAGAAAACATGGATCTTTACCTTTCCCCAGTGGCCCAGAGCCAGGAGTTCTCTGGCCGC
TCTCTGGACAGATTACCTAAAACCAGATCCATGGATGATCTTCTTTCTGCCTGTGACACA
AGCAGCCCCCTGACTCGTACATCCAGTGACCCTAACCTGAATAACCACTGTCAGGAGGTC
AGGGTAGGCCTGGAGCCCTGGCACAGCAATCCTGAGGGATCAGAGACAAGCTTTGTGGAC
TCTGGGGTAGGAGGGCCTCAGCAAACTGTAGGAGAAGTGGGTCTTCCTCCTCCTCTGCCC
AGCAGCCAGAAAGACTACTTGAGCAATAAACCTTTCAAGAGTCACAAAAGCTGTTCTCCA
AGTTACAAACTGCTTAATACCGCAGTGCCTCGGGAAATGAAGAGCAACACCTCTGATCCT
GAGATCAAAGTCCTAGAAGAGACTAAGGGACCAGCTCCAGACCCTTCTGCCCAGGATGAG
CTGGGTAGGACTTTAGATGGCATAGGGGAGCCACCTGAACATTGTCCTGAAACAGAAGCT
GTCAGTGCACTCTCCAAGGTCATTTCTAACAAGTGTGATGGAGTTTGTAATTTTCCTGAG
TCTTCCCAGAACTCTCCTACAGGTACGCCCCAACAGGCCCAGCCAGACTCCATGCTAGGT
GTGCCCTCCAAGTGTGTTCTTGATCACAGCCTCAGCACCGTTTGCAACCCACCGAGTGCT
GCCTGCCAAACTCCTCTAGACCCAAGCACTGACTTCCTCAACCAAGATCCCTCAGGGTCT
GTGGCAAGTATCTCCCACCAGGAACAACTGAGTTCTGTGCCGGATCTGACCCATGGGGAG
GAAGACATTGGTAAAAGAGGAAATAATAGGAATGGGCAGTTATTGGAAAATCCTCGCTTT
GGGAAAATGCCATTGGAATTGGTCCGGAAGCCAATTTCTCAGAGCCAGATCAGTGAGTTC
TCTTTTCTAGGGTCCAACTGGGACAGCTTCCAAGGGATGGTGACTTCATTCCCAAGTGGG
GAGGCCACCCCTCGGCGGCTGCTTTCCTATGGCTGTTGTAGCAAGAGGCCAAACAGTAAG
CAGATGCGGGCCACAGGGCCCTGCTTTGGGGGCCAGTGGGCTCAGAGAGAAGGTGTGAAG
TCACCTGTCTGTTCTAGTCATTCCAATGGACATTGTACTGGCCCAGGAGGAAAGAACCAG
ATGTGGTTGTCCAGTCATCCAAAGCAAGTCTCTAGCACAAAGCCCGTTCCACTGAACTGC
CCTTCTCCAGTGCCTCCTCTGTATTTGGATGATGATGGACTCCCCTTTCCCACGGATGTG
ATCCAGCATAGGTTACGGCAAATCGAAGCAGGGTACAAACAAGAGGTGGAGCAGCTACGT
CGACAGGTGCGTGAGCTTCAGATGAGGCTGGACATCCGTCACTGCTGTGCCCCTCCAGCA
GAGCCCCCCATGGACTATGAGGATGATTTTACATGTTTGAAGGAGTCAGATGGCAGTGAT
ACTGAGGATTTTGGCTCTGATCACAGTGAAGACTGCCTTTCAGAAGCAAGCTGGGAACCT
GTTGATAAGAAAGAGACTGAGGTGACTCGCTGGGTTCCAGACCATATGGCATCACACTGC
TATAACTGTGACTGTGAATTCTGGTTGGCCAAACGAAGACACCATTGCAGAAATTGTGGG
AATGTATTTTGTGCTGGATGCTGCCACCTGAAGCTGCCCATTCCTGATCAGCAACTCTAT
GACCCAGTTCTCGTCTGTAACTCATGTTACGAACACATTCAAGTCTCTCGTGCCAGGGAA
CTCATGAGCCAACAGCTGAAGAAACCCATTGCTACAGCTTCCAGTTGA

Protein Properties

Number of Residues

1195

Molecular Weight

133352.17

Theoretical pI

6.043

Pfam Domain Function

FYVE (PF01363 )
Myotub-related (PF06602 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Myotubularin-related protein 4
MGEEGPPSLEYIQAKDLFPPKELVKEEENLQVPFTVLQGEGVEFLGRAADALIAISNYRL
HIKFKDSVINVPLRMIDSVESRDMFQLHISCKDSKVVRCHFSTFKQCQEWLSRLSRATAR
PAKPEDLFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHIN
SNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISW
WGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVEST
AAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC
SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVAL
AKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQL
LKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKN
FHNFLYTPSSDMVLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGR
SLDRLPKTRSMDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVD
SGVGGPQQTVGEVGLPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDP
EIKVLEETKGPAPDPSAQDELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPE
SSQNSPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGS
VASISHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEF
SFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREGVK
SPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPFPTDV
IQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLKESDGSD
TEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKRRHHCRNCG
NVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPIATASS

External Links

GenBank ID Protein

20521119

UniProtKB/Swiss-Prot ID

Q9NYA4

UniProtKB/Swiss-Prot Entry Name

MTMR4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB014547

GeneCard ID