Cannabis Compound Database: Showing Protein M-phase inducer phosphatase 3 (CDBP04130)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP04130

Secondary Accession Numbers

Not Available

Name

M-phase inducer phosphatase 3

Description

Not Available

Synonyms

Dual specificity phosphatase Cdc25C

Gene Name

CDC25C

Protein Type

Enzyme

Biological Properties

General Function

Involved in protein tyrosine phosphatase activity

Specific Function

Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

GO Classification

Biological Process
mitosis
cell division
M phase of mitotic cell cycle
traversing start control point of mitotic cell cycle
G2/M transition of mitotic cell cycle
cell proliferation
DNA replication
cell cycle checkpoint
regulation of cyclin-dependent protein kinase activity
virus-host interaction
regulation of mitosis
Cellular Component
cytosol
nucleoplasm
Component
cell part
intracellular
Function
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
Molecular Function
protein tyrosine phosphatase activity
Process
dephosphorylation
m phase of mitotic cell cycle
protein amino acid dephosphorylation
metabolic process
cellular process
cellular metabolic process
cell cycle process
cell cycle phase
phosphorus metabolic process
phosphate metabolic process
m phase

Cellular Location

Nucleus

Pathways

Name	SMPDB/Pathwhiz	KEGG
Cell cycle	Not Available
Oocyte meiosis	Not Available
Progesterone-mediated oocyte maturation	Not Available

Gene Properties

Chromosome Location

Locus

5q31

SNPs

CDC25C

Gene Sequence

>1422 bp
ATGTCTACGGAACTCTTCTCATCCACAAGAGAGGAAGGAAGCTCTGGCTCAGGACCCAGT
TTTAGGTCTAATCAAAGGAAAATGTTAAACCTGCTCCTGGAGAGAGACACTTCCTTTACC
GTCTGTCCAGATGTCCCTAGAACTCCAGTGGGCAAATTTCTTGGTGATTCTGCAAACCTA
AGCATTTTGTCTGGAGGAACCCCAAAACGTTGCCTCGATCTTTCGAATCTTAGCAGTGGG
GAGATAACTGCCACTCAGCTTACCACTTCTGCAGACCTTGATGAAACTGGTCACCTGGAT
TCTTCAGGACTTCAGGAAGTGCATTTAGCTGGGATGAATCATGACCAGCACCTAATGAAA
TGTAGCCCAGCACAGCTTCTTTGTAGCACTCCGAATGGTTTGGACCGTGGCCATAGAAAG
AGAGATGCAATGTGTAGTTCATCTGCAAATAAAGAAAATGACAATGGAAACTTGGTGGAC
AGTGAAATGAAATATTTGGGCAGTCCCATTACTACTGTTCCAAAATTGGATAAAAATCCA
AACCTAGGAGAAGACCAGGCAGAAGAGATTTCAGATGAATTAATGGAGTTTTCCCTGAAA
GATCAAGAAGCAAAGGTGAGCAGAAGTGGCCTATATCGCTCCCCGTCGATGCCAGAGAAC
TTGAACAGGCCAAGACTGAAGCAGGTGGAAAAATTCAAGGACAACACAATACCAGATAAA
GTTAAAAAAAAGTATTTTTCTGGCCAAGGAAAGCTCAGGAAGGGCTTATGTTTAAAGAAG
ACAGTCTCTCTGTGTGACATTACTATCACTCAGATGCTGGAGGAAGATTCTAACCAGGGG
CACCTGATTGGTGATTTTTCCAAGGTATGTGCGCTGCCAACCGTGTCAGGGAAACACCAA
GATCTGAAGTATGTCAACCCAGAAACAGTGGCTGCCTTACTGTCGGGGAAGTTCCAGGGT
CTGATTGAGAAGTTTTATGTCATTGATTGTCGCTATCCATATGAGTATCTGGGAGGACAC
ATCCAGGGAGCCTTAAACTTATATAGTCAGGAAGAACTGTTTAACTTCTTTCTGAAGAAG
CCCATCGTCCCTTTGGACACCCAGAAGAGAATAATCATCGTGTTCCACTGTGAATTCTCC
TCAGAGAGGGGCCCCCGAATGTGCCGCTGTCTGCGTGAAGAGGACAGGTCTCTGAACCAG
TATCCTGCATTGTACTACCCAGAGCTATATATCCTTAAAGGCGGCTACAGAGACTTCTTT
CCAGAATATATGGAACTGTGTGAACCACAGAGCTACTGCCCTATGCATCATCAGGACCAC
AAGACTGAGTTGCTGAGGTGTCGAAGCCAGAGCAAAGTGCAGGAAGGGGAGCGGCAGCTG
CGGGAGCAGATTGCCCTTCTGGTGAAGGACATGAGCCCATGA

Protein Properties

Number of Residues

473

Molecular Weight

53364.17

Theoretical pI

6.784

Pfam Domain Function

Rhodanese (PF00581 )
M-inducer_phosp (PF06617 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>M-phase inducer phosphatase 3
MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANL
SILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMK
CSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNP
NLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDK
VKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQ
DLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKK
PIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFF
PEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP

External Links

GenBank ID Protein

125625350

UniProtKB/Swiss-Prot ID

P30307

UniProtKB/Swiss-Prot Entry Name

MPIP3_HUMAN

PDB IDs