| Identification |
|---|
| HMDB Protein ID
| CDBP04124 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 8 |
| Description
| Not Available |
| Synonyms
|
- Dual specificity protein phosphatase hVH-5
|
| Gene Name
| DUSP8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (By similarity).
|
| GO Classification
|
| Cellular Component |
| cytoplasm |
| nucleus |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| map kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| Molecular Function |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| cellular metabolic process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.5 |
| SNPs
| DUSP8 |
| Gene Sequence
|
>1878 bp
ATGGCTGGGGACCGGCTCCCGAGGAAGGTGATGGATGCCAAGAAGCTGGCCAGCCTGCTG
CGGGGCGGGCCTGGGGGGCCGCTGGTCATCGACAGCCGCTCCTTCGTGGAGTACAACAGC
TGGCATGTGCTCAGCTCCGTCAACATCTGCTGCTCCAAGCTGGTGAAGCGGCGGCTGCAG
CAGGGCAAGGTGACCATTGCGGAGCTCATCCAGCCGGCTGCACGCAGCCAGGTGGAGGCT
ACGGAGCCACAGGACGTGGTGGTCTATGACCAGAGCACGCGGGACGCCAGCGTGCTGGCC
GCAGACAGCTTCCTCTCCATCCTGCTGAGCAAGCTGGACGGCTGCTTCGACAGCGTGGCC
ATCCTCACTGGGGGCTTCGCCACCTTCTCCTCCTGCTTCCCCGGCCTCTGCGAGGGCAAG
CCTGCTGCCCTGCTACCCATGAGCCTCTCCCAGCCCTGCCTGCCTGTGCCCAGCGTGGGC
CTGACCCGCATCCTGCCTCACCTCTACCTGGGCTCGCAGAAGGACGTCCTAAACAAGGAT
CTGATGACGCAAAATGGAATAAGCTACGTCCTCAACGCCAGCAACTCCTGCCCCAAGCCT
GACTTCATCTGCGAGAGCCGCTTCATGCGGGTCCCCATCAACGACAACTACTGTGAAAAA
CTGCTGCCCTGGCTGGACAAGTCCATCGAGTTCATCGATAAAGCCAAGCTCTCCAGCTGC
CAAGTCATCGTCCACTGTCTGGCTGGCATCTCCCGCTCTGCCACCATCGCCATCGCCTAC
ATCATGAAGACCATGGGCATGTCCTCCGACGACGCCTACAGGTTCGTGAAGGACAGGCGC
CCGTCCATCTCGCCCAACTTCAACTTCCTGGGCCAGCTGCTGGAGTACGAGCGCAGCCTG
AAGCTGCTGGCCGCCCTGCAGGGCGACCCGGGCACCCCCTCAGGGACGCCGGAGCCTCCG
CCCAGTCCTGCCGCCGGGGCCCCGCTGCCACGGCTGCCACCACCTACCTCAGAGAGCGCT
GCCACAGGGAATGCGGCTGCCAGGGAGGGCGGCCTGAGCGCGGGCGGGGAGCCCCCCGCG
CCCCCCACGCCCCCGGCGACCAGCGCACTGCAGCAGGGCCTGCGCGGCCTGCACCTCTCC
TCGGACCGCCTGCAGGACACTAACCGCCTCAAGCGCTCCTTCTCCCTGGACATCAAGTCT
GCCTACGCCCCTAGCAGGCGGCCCGACGGCCCCGGGCCCCCCGACCCCGGCGAGGCCCCG
AAGCTCTGCAAGCTGGACAGCCCGTCGGGGGCCGCGCTGGGCCTGTCCTCGCCCAGCCCG
GACAGCCCGGACGCCGCGCCTGAGGCGCGCCCACGGCCCCGCCGGCGGCCCCGGCCCCCC
GCCGGCTCCCCCGCGCGCTCCCCCGCGCACAGCCTCGGCCTGAACTTCGGCGATGCGGCC
CGGCAGACTCCGCGGCACGGCCTCTCGGCCCTGTCGGCGCCCGGGCTGCCCGGCCCTGGC
CAGCCGGCCGGCCCCGGGGCCTGGGCACCGCCGCTTGACTCCCCAGGCACGCCGTCGCCC
GACGGGCCCTGGTGCTTCAGCCCCGAGGGCGCACAGGGGGCGGGCGGGGTGCTGTTTGCG
CCCTTCGGCCGGGCGGGCGCCCCGGGACCAGGCGGCGGCAGCGACCTGCGGCGGCGGGAG
GCAGCGAGGGCTGAGCCCCGGGACGCGCGGACCGGCTGGCCCGAGGAGCCGGCCCCGGAG
ACGCAGTTCAAGCGCCGCAGCTGCCAGATGGAGTTCGAGGAGGGCATGGTGGAGGGGCGC
GCGCGCGGCGAGGAGCTGGCCGCCCTGGGCAAGCAGGCGAGCTTCTCGGGCAGCGTGGAG
GTCATCGAGGTGTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 625 |
| Molecular Weight
| 65825.96 |
| Theoretical pI
| 8.234 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 8
MAGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQ
QGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAADSFLSILLSKLDGCFDSVA
ILTGGFATFSSCFPGLCEGKPAALLPMSLSQPCLPVPSVGLTRILPHLYLGSQKDVLNKD
LMTQNGISYVLNASNSCPKPDFICESRFMRVPINDNYCEKLLPWLDKSIEFIDKAKLSSC
QVIVHCLAGISRSATIAIAYIMKTMGMSSDDAYRFVKDRRPSISPNFNFLGQLLEYERSL
KLLAALQGDPGTPSGTPEPPPSPAAGAPLPRLPPPTSESAATGNAAAREGGLSAGGEPPA
PPTPPATSALQQGLRGLHLSSDRLQDTNRLKRSFSLDIKSAYAPSRRPDGPGPPDPGEAP
KLCKLDSPSGAALGLSSPSPDSPDAAPEARPRPRRRPRPPAGSPARSPAHSLGLNFGDAA
RQTPRHGLSALSAPGLPGPGQPAGPGAWAPPLDSPGTPSPDGPWCFSPEGAQGAGGVLFA
PFGRAGAPGPGGGSDLRRREAARAEPRDARTGWPEEPAPETQFKRRSCQMEFEEGMVEGR
ARGEELAALGKQASFSGSVEVIEVS
|
| External Links |
|---|
| GenBank ID Protein
| 54887329 |
| UniProtKB/Swiss-Prot ID
| Q13202 |
| UniProtKB/Swiss-Prot Entry Name
| DUS8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC038231 |
| GeneCard ID
| DUSP8 |
| GenAtlas ID
| DUSP8 |
| HGNC ID
| HGNC:3074 |
| References |
|---|
| General References
| Not Available |