| Identification |
|---|
| HMDB Protein ID
| CDBP04122 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 6 |
| Description
| Not Available |
| Synonyms
|
- Dual specificity protein phosphatase PYST1
- MAP kinase phosphatase 3
- MKP-3
- Mitogen-activated protein kinase phosphatase 3
|
| Gene Name
| DUSP6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Inactivates MAP kinases. Has a specificity for the ERK family.
|
| GO Classification
|
| Biological Process |
| toll-like receptor 1 signaling pathway |
| toll-like receptor 2 signaling pathway |
| toll-like receptor 3 signaling pathway |
| toll-like receptor 4 signaling pathway |
| TRIF-dependent toll-like receptor signaling pathway |
| dorsal/ventral pattern formation |
| positive regulation of apoptotic process |
| regulation of endodermal cell fate specification |
| response to nitrosative stress |
| regulation of fibroblast growth factor receptor signaling pathway |
| response to drug |
| regulation of heart growth |
| innate immune response |
| response to growth factor stimulus |
| cell differentiation |
| nerve growth factor receptor signaling pathway |
| response to organic cyclic compound |
| peptidyl-tyrosine dephosphorylation |
| MyD88-dependent toll-like receptor signaling pathway |
| negative regulation of ERK1 and ERK2 cascade |
| stress-activated MAPK cascade |
| Toll signaling pathway |
| Cellular Component |
| cytosol |
| nucleoplasm |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| map kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| Molecular Function |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  | | Transcriptional misregulation in cancer | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q22-q23 |
| SNPs
| DUSP6 |
| Gene Sequence
|
>1146 bp
ATGATAGATACGCTCAGACCCGTGCCCTTCGCGTCGGAAATGGCGATCAGCAAGACGGTG
GCGTGGCTCAACGAGCAGCTGGAGCTGGGCAACGAGCGGCTGCTGCTGATGGACTGCCGG
CCGCAGGAGCTATACGAGTCGTCGCACATCGAGTCGGCCATCAACGTGGCCATCCCGGGC
ATCATGCTGCGGCGCCTGCAGAAGGGTAACCTGCCGGTGCGCGCGCTCTTCACGCGCGGC
GAGGACCGGGACCGCTTCACCCGGCGCTGTGGCACCGACACAGTGGTGCTCTACGACGAG
AGCAGCAGCGACTGGAACGAGAATACGGGCGGCGAGTCGTTGCTCGGGCTGCTGCTCAAG
AAGCTCAAGGACGAGGGCTGCCGGGCGTTCTACCTGGAAGGTGGCTTCAGTAAGTTCCAA
GCCGAGTTCTCCCTGCATTGCGAGACCAATCTAGACGGCTCGTGTAGCAGCAGCTCGCCG
CCGTTGCCAGTGCTGGGGCTCGGGGGCCTGCGGATCAGCTCTGACTCTTCCTCGGACATC
GAGTCTGACCTTGACCGAGACCCCAATAGTGCAACAGACTCGGATGGTAGTCCGCTGTCC
AACAGCCAGCCTTCCTTCCCAGTGGAGATCTTGCCCTTCCTCTACTTGGGCTGTGCCAAA
GACTCCACCAACTTGGACGTGTTGGAGGAATTCGGCATCAAGTACATCTTGAACGTCACC
CCCAATTTGCCGAATCTCTTTGAGAACGCAGGAGAGTTTAAATACAAGCAAATCCCCATC
TCGGATCACTGGAGCCAAAACCTGTCCCAGTTTTTCCCTGAGGCCATTTCTTTCATAGAT
GAAGCCCGGGGCAAGAACTGTGGTGTCTTGGTACATTGCTTGGCTGGCATTAGCCGCTCA
GTCACTGTGACTGTGGCTTACCTTATGCAGAAGCTCAATCTGTCGATGAACGATGCCTAT
GACATTGTCAAAATGAAAAAATCCAACATATCCCCTAACTTCAACTTCATGGGTCAGCTG
CTGGACTTCGAGAGGACGCTGGGACTCAGCAGCCCATGTGACAACAGGGTTCCAGCACAG
CAGCTGTATTTTACCACCCCTTCCAACCAGAATGTATACCAGGTGGACTCTCTGCAATCT
ACGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 381 |
| Molecular Weight
| 42319.27 |
| Theoretical pI
| 4.885 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 6
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPG
IMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLK
KLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI
ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT
PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS
VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQ
QLYFTTPSNQNVYQVDSLQST
|
| External Links |
|---|
| GenBank ID Protein
| 1418934 |
| UniProtKB/Swiss-Prot ID
| Q16828 |
| UniProtKB/Swiss-Prot Entry Name
| DUS6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X93920 |
| GeneCard ID
| DUSP6 |
| GenAtlas ID
| DUSP6 |
| HGNC ID
| HGNC:3072 |
| References |
|---|
| General References
| Not Available |