| Identification |
|---|
| HMDB Protein ID
| CDBP04121 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 5 |
| Description
| Not Available |
| Synonyms
|
- Dual specificity protein phosphatase hVH3
|
| Gene Name
| DUSP5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Displays phosphatase activity toward several substrates. The highest relative activity is toward ERK1.
|
| GO Classification
|
| Biological Process |
| negative regulation of transcription, DNA-dependent |
| endoderm formation |
| Cellular Component |
| nucleoplasm |
| Function |
| map kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| Molecular Function |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Nucleus (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10q25 |
| SNPs
| DUSP5 |
| Gene Sequence
|
>1155 bp
ATGAAGGTCACGTCGCTCGACGGGCGCCAGCTGCGCAAGATGCTCCGCAAGGAGGCGGCG
GCGCGCTGCGTGGTGCTCGACTGCCGGCCCTATCTGGCCTTCGCTGCCTCGAACGTGCGC
GGCTCGCTCAACGTCAACCTCAACTCGGTGGTGCTGCGGCGGGCCCGGGGCGGCGCGGTG
TCGGCGCGCTACGTGCTGCCCGACGAGGCGGCGCGCGCGCGGCTCCTGCAGGAGGGCGGC
GGCGGCGTCGCGGCCGTGGTGGTGCTGGACCAGGGCAGCCGCCACTGGCAGAAGCTGCGA
GAGGAGAGCGCCGCGCGTGTCGTCCTCACCTCGCTACTCGCTTGCCTACCCGCCGGCCCG
CGGGTCTACTTCCTCAAAGGGGGATATGAGACTTTCTACTCGGAATATCCTGAGTGTTGC
GTGGATGTAAAACCCATTTCACAAGAGAAGATTGAGAGTGAGAGAGCCCTCATCAGCCAG
TGTGGAAAACCAGTGGTAAATGTCAGCTACAGGCCAGCTTATGACCAGGGTGGCCCAGTT
GAAATCCTTCCCTTCCTCTACCTTGGAAGTGCCTACCATGCATCCAAGTGCGAGTTCCTC
GCCAACCTGCACATCACAGCCCTGCTGAATGTCTCCCGACGGACCTCCGAGGCCTGCGCG
ACCCACCTACACTACAAATGGATCCCTGTGGAAGACAGCCACACGGCTGACATTAGCTCC
CACTTTCAAGAAGCAATAGACTTCATTGACTGTGTCAGGGAAAAGGGAGGCAAGGTCCTG
GTCCACTGTGAGGCTGGGATCTCCCGTTCACCCACCATCTGCATGGCTTACCTTATGAAG
ACCAAGCAGTTCCGCCTGAAGGAGGCCTTCGATTACATCAAGCAGAGGAGGAGCATGGTC
TCGCCCAACTTTGGCTTCATGGGCCAGCTCCTGCAGTACGAATCTGAGATCCTGCCCTCC
ACGCCCAACCCCCAGCCTCCCTCCTGCCAAGGGGAGGCAGCAGGCTCTTCACTGATAGGC
CATTTGCAGACACTGAGCCCTGACATGCAGGGTGCCTACTGCACATTCCCTGCCTCGGTG
CTGGCACCGGTGCCTACCCACTCAACAGTCTCAGAGCTCAGCAGAAGCCCTGTGGCAACG
GCCACATCCTGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 384 |
| Molecular Weight
| 42046.885 |
| Theoretical pI
| 8.346 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 5
MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGGAV
SARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPAGP
RVYFLKGGYETFYSEYPECCVDVKPISQEKIESERALISQCGKPVVNVSYRPAYDQGGPV
EILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPVEDSHTADISS
HFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAFDYIKQRRSMV
SPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQGAYCTFPASV
LAPVPTHSTVSELSRSPVATATSC
|
| External Links |
|---|
| GenBank ID Protein
| 55958676 |
| UniProtKB/Swiss-Prot ID
| Q16690 |
| UniProtKB/Swiss-Prot Entry Name
| DUS5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL355512 |
| GeneCard ID
| DUSP5 |
| GenAtlas ID
| DUSP5 |
| HGNC ID
| HGNC:3071 |
| References |
|---|
| General References
| Not Available |