| Identification |
|---|
| HMDB Protein ID
| CDBP04119 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 3 |
| Description
| Not Available |
| Synonyms
|
- Dual specificity protein phosphatase VHR
- Vaccinia H1-related phosphatase
- VHR
|
| Gene Name
| DUSP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.
|
| GO Classification
|
| Biological Process |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of T cell activation |
| negative regulation of T cell receptor signaling pathway |
| stress-activated MAPK cascade |
| Toll signaling pathway |
| toll-like receptor 1 signaling pathway |
| toll-like receptor 2 signaling pathway |
| toll-like receptor 3 signaling pathway |
| toll-like receptor 4 signaling pathway |
| TRIF-dependent toll-like receptor signaling pathway |
| nerve growth factor receptor signaling pathway |
| positive regulation of mitotic cell cycle |
| in utero embryonic development |
| innate immune response |
| negative regulation of JNK cascade |
| MyD88-dependent toll-like receptor signaling pathway |
| Cellular Component |
| cytosol |
| nucleoplasm |
| immunological synapse |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| Molecular Function |
| protein tyrosine/serine/threonine phosphatase activity |
| MAP kinase phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q21 |
| SNPs
| DUSP3 |
| Gene Sequence
|
>558 bp
ATGTCGGGCTCGTTCGAGCTCTCGGTGCAGGATCTCAACGACCTGCTCTCGGACGGCAGC
GGCTGCTACAGCCTCCCGAGCCAGCCCTGCAACGAGGTCACCCCGCGGATCTACGTGGGC
AACGCGTCTGTGGCTCAGGACATCCCCAAGCTGCAGAAACTAGGCATCACCCATGTGCTG
AACGCGGCTGAGGGCAGGTCCTTCATGCACGTCAACACCAATGCCAACTTCTACAAGGAC
TCCGGCATCACATACCTGGGCATCAAGGCCAACGACACACAGGAGTTCAACCTCAGCGCT
TACTTTGAAAGGGCTGCCGACTTCATTGACCAGGCTTTGGCTCAAAAGAATGGCCGGGTG
CTCGTCCACTGCCGGGAAGGTTATAGCCGCTCCCCAACGCTAGTTATCGCCTACCTCATG
ATGCGGCAGAAGATGGACGTCAAGTCTGCCCTGAGCATCGTGAGGCAGAACCGTGAGATC
GGCCCCAACGATGGCTTCCTGGCCCAGCTCTGCCAGCTCAATGACAGACTAGCCAAGGAG
GGGAAGTTGAAACCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 185 |
| Molecular Weight
| 20478.1 |
| Theoretical pI
| 7.796 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 3
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVL
NAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRV
LVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE
GKLKP
|
| External Links |
|---|
| GenBank ID Protein
| 12803693 |
| UniProtKB/Swiss-Prot ID
| P51452 |
| UniProtKB/Swiss-Prot Entry Name
| DUS3_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC002682 |
| GeneCard ID
| DUSP3 |
| GenAtlas ID
| DUSP3 |
| HGNC ID
| HGNC:3069 |
| References |
|---|
| General References
| Not Available |