| Identification |
|---|
| HMDB Protein ID
| CDBP04112 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dual specificity protein phosphatase 10 |
| Description
| Not Available |
| Synonyms
|
- MAP kinase phosphatase 5
- MKP-5
- Mitogen-activated protein kinase phosphatase 5
|
| Gene Name
| DUSP10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily.
|
| GO Classification
|
| Biological Process |
| regulation of adaptive immune response |
| peptidyl-tyrosine dephosphorylation |
| response to lipopolysaccharide |
| JNK cascade |
| negative regulation of JNK cascade |
| negative regulation of JUN kinase activity |
| negative regulation of respiratory burst involved in inflammatory response |
| Cellular Component |
| Golgi apparatus |
| nucleus |
| Function |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| map kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine/serine/threonine phosphatase activity |
| Molecular Function |
| MAP kinase tyrosine/serine/threonine phosphatase activity |
| protein tyrosine phosphatase activity |
| Process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
| phosphorus metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q41 |
| SNPs
| DUSP10 |
| Gene Sequence
|
>1449 bp
ATGCCTCCGTCTCCTTTAGACGACAGGGTAGTAGTGGCACTATCTAGGCCCGTCCGACCT
CAGGATCTCAACCTTTGTTTAGACTCTAGTTACCTTGGCTCTGCCAACCCAGGCAGTAAC
AGCCACCCTCCTGTCATCGCCACCACCGTTGTGTCCCTCAAGGCTGCGAATCTGACGTAT
ATGCCCTCATCCAGCGGCTCTGCCCGCTCGCTGAATTGTGGATGCAGCAGTGCCAGCTGC
TGCACTGTGGCAACCTACGACAAGGACAATCAGGCCCAAACCCAAGCCATTGCCGCTGGC
ACCACCACCACTGCCATCGGAACCTCTACCACCTGCCCTGCTAACCAGATGGTCAACAAT
AATGAGAATACAGGCTCTCTAAGTCCATCAAGTGGGGTGGGCAGCCCTGTGTCAGGGACC
CCCAAGCAGCTAGCCAGCATCAAAATAATCTACCCCAATGACTTGGCAAAGAAGATGACC
AAATGCAGCAAGAGTCACCTGCCGAGTCAGGGCCCTGTCATCATTGACTGCAGGCCCTTC
ATGGAGTACAACAAGAGTCACATCCAAGGAGCTGTCCACATTAACTGTGCCGATAAGATC
AGCCGGCGGAGACTGCAGCAGGGCAAGATCACTGTCCTAGACTTGATTTCCTGTAGGGAA
GGCAAGGACTCTTTCAAGAGGATCTTTTCCAAAGAAATTATAGTTTATGATGAGAATACC
AATGAACCAAGCCGAGTGATGCCCTCCCAGCCACTTCACATAGTCCTCGAGTCCCTGAAG
AGAGAAGGCAAAGAACCTCTGGTGTTGAAAGGTGGACTTAGTAGTTTTAAGCAGAACCAT
GAAAACCTCTGTGACAACTCCCTCCAGCTCCAAGAGTGCCGGGAGGTGGGGGGCGGCGCA
TCCGCGGCCTCGAGCTTGCTACCTCAGCCCATCCCCACCACCCCTGACATCGAGAACGCT
GAGCTCACCCCCATCTTGCCCTTCCTGTTCCTTGGCAATGAGCAGGATGCTCAGGACCTG
GACACCATGCAGCGGCTGAACATCGGCTACGTCATCAACGTCACCACTCATCTTCCCCTC
TACCACTATGAGAAAGGCCTGTTCAACTACAAGCGGCTGCCAGCCACTGACAGCAACAAG
CAGAACCTGCGGCAGTACTTTGAAGAGGCTTTTGAGTTCATTGAGGAAGCTCACCAGTGT
GGGAAGGGGCTTCTCATCCACTGCCAGGCTGGGGTGTCCCGCTCCGCCACCATCGTCATC
GCTTACTTGATGAAGCACACTCGGATGACCATGACTGATGCTTATAAATTTGTCAAAGGC
AAACGACCAATTATCTCCCCAAACCTTAACTTCATGGGGCAGTTGCTAGAGTTCGAGGAA
GACCTAAACAACGGTGTGACACCGAGAATCCTTACACCAAAGCTGATGGGCGTGGAGACG
GTTGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 482 |
| Molecular Weight
| 52641.635 |
| Theoretical pI
| 7.736 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity protein phosphatase 10
MPPSPLDDRVVVALSRPVRPQDLNLCLDSSYLGSANPGSNSHPPVIATTVVSLKAANLTY
MPSSSGSARSLNCGCSSASCCTVATYDKDNQAQTQAIAAGTTTTAIGTSTTCPANQMVNN
NENTGSLSPSSGVGSPVSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPF
MEYNKSHIQGAVHINCADKISRRRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENT
NEPSRVMPSQPLHIVLESLKREGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGA
SAASSLLPQPIPTTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPL
YHYEKGLFNYKRLPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVI
AYLMKHTRMTMTDAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVET
VV
|
| External Links |
|---|
| GenBank ID Protein
| 5138995 |
| UniProtKB/Swiss-Prot ID
| Q9Y6W6 |
| UniProtKB/Swiss-Prot Entry Name
| DUS10_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB026436 |
| GeneCard ID
| DUSP10 |
| GenAtlas ID
| DUSP10 |
| HGNC ID
| HGNC:3065 |
| References |
|---|
| General References
| Not Available |