| Identification |
|---|
| HMDB Protein ID
| CDBP04111 |
| Secondary Accession Numbers
| Not Available |
| Name
| CTD nuclear envelope phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- Serine/threonine-protein phosphatase dullard
|
| Gene Name
| CTDNEP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at differents levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling.
|
| GO Classification
|
| Biological Process |
| positive regulation of triglyceride biosynthetic process |
| nuclear envelope organization |
| protein dephosphorylation |
| protein localization to nucleus |
| Cellular Component |
| endoplasmic reticulum membrane |
| nuclear membrane |
| integral to membrane |
| Nem1-Spo7 phosphatase complex |
| Function |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| protein serine/threonine phosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Single-pass membrane protein
- Single-pass membrane protein
- Nucleus membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17p13 |
| SNPs
| DULLARD |
| Gene Sequence
|
>735 bp
ATGATGCGGACGCAGTGTCTGCTGGGGCTGCGCACGTTCGTGGCCTTCGCCGCCAAGCTC
TGGAGCTTCTTCATTTACCTTCTGCGGAGGCAGATCCGCACGGTAATTCAGTACCAAACT
GTTCGATATGATATCCTCCCCTTATCTCCTGTGTCCCGGAATCGGCTAGCCCAGGTGAAG
AGGAAGATCCTGGTGCTGGATCTGGATGAGACACTTATTCACTCCCACCATGATGGGGTC
CTGAGGCCCACAGTCCGGCCTGGTACGCCTCCTGACTTCATCCTCAAGGTGGTAATAGAC
AAACATCCTGTCCGGTTTTTTGTACATAAGAGGCCCCATGTGGATTTCTTCCTGGAAGTG
GTGAGCCAGTGGTACGAGCTGGTGGTGTTTACAGCAAGCATGGAGATCTATGGCTCTGCT
GTGGCAGATAAACTGGACAATAGCAGAAGCATTCTTAAGAGGAGATATTACAGACAGCAC
TGCACTTTGGAGTTGGGCAGCTACATCAAGGACCTCTCTGTGGTCCACAGTGACCTCTCC
AGCATTGTGATCCTGGATAACTCCCCAGGGGCTTACAGGAGCCATCCAGACAATGCCATC
CCCATCAAATCCTGGTTCAGTGACCCCAGCGACACAGCCCTTCTCAACCTGCTCCCAATG
CTGGATGCCCTCAGGTTCACCGCTGATGTTCGTTCCGTGCTGAGCCGAAACCTTCACCAA
CATCGGCTCTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 28376.745 |
| Theoretical pI
| 9.766 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase dullard
MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVK
RKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEV
VSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLS
SIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQ
HRLW
|
| External Links |
|---|
| GenBank ID Protein
| 219555649 |
| UniProtKB/Swiss-Prot ID
| O95476 |
| UniProtKB/Swiss-Prot Entry Name
| DULRD_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001143775.1 |
| GeneCard ID
| DULLARD |
| GenAtlas ID
| DULLARD |
| HGNC ID
| HGNC:19085 |
| References |
|---|
| General References
| Not Available |