| Identification |
|---|
| HMDB Protein ID
| CDBP04110 |
| Secondary Accession Numbers
| Not Available |
| Name
| RNA polymerase II subunit A C-terminal domain phosphatase |
| Description
| Not Available |
| Synonyms
|
- TFIIF-associating CTD phosphatase
|
| Gene Name
| CTDP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphoprotein phosphatase activity |
| Specific Function
| Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation.
|
| GO Classification
|
| Biological Process |
| transcription elongation from RNA polymerase II promoter |
| protein dephosphorylation |
| cell division |
| viral reproduction |
| exit from mitosis |
| mitosis |
| positive regulation of viral transcription |
| Cellular Component |
| centrosome |
| actin cytoskeleton |
| cytoplasm |
| nucleoplasm |
| midbody |
| spindle midzone |
| spindle pole |
| Component |
| cell part |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| intracellular |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| phosphoprotein phosphatase activity |
| Molecular Function |
| CTD phosphatase activity |
| DNA-directed RNA polymerase activity |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q23 |
| SNPs
| CTDP1 |
| Gene Sequence
|
>2886 bp
ATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCCGAGGGCGCCCCGACGGCGGCTGTGGCC
GAGGTGCGCTGCCCGGGGCCCGCGCCGCTGCGCCTGCTGGAGTGGAGGGTGGCGGCGGGC
GCGGCCGTGCGCATCGGCTCGGTGCTGGCCGTGTTCGAGGCCGCCGCCTCCGCGCAGTCC
TCCGGGGCCTCTCAGTCCCGTGTAGCCTCCGGGGGCTGCGTGCGCCCCGCGCGGCCGGAA
CGCAGGCTGAGGTCGGAGCGCGCGGGCGTGGTGCGGGAGCTGTGCGCGCAGCCGGGCCAG
GTGGTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCACCCGGTTGTCATG
AAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAG
CAGCAGGTGCCGCTGTCCACGGCGACCGTGTCCATGGTGCACAGCGTGCCGGAGTTGATG
GTGAGCTCCGAGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAAC
CGGAAGCTGGTGCTCATGGTGGACTTGGACCAGACGTTGATTCACACAACCGAGCAGCAC
TGTCAGCAGATGTCGAATAAAGGCATCTTTCACTTCCAGCTGGGCCGGGGTGAGCCCATG
CTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAGAAGATCGCCAAGCTGTAC
GAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGCAGGCTTTTTA
GACCCCGAGAAGAAGCTTTTTTCTCACCGAATATTATCAAGGGATGAATGTATTGACCCA
TTTTCTAAAACGGGAAACCTTAGAAATCTCTTTCCTTGTGGAGACTCAATGGTTTGCATT
ATTGATGATCGAGAAGATGTCTGGAAGTTTGCCCCCAATCTGATAACTGTGAAGAAATAT
GTATACTTCCAGGGCACGGGTGATATGAATGCGCCCCCTGGGTCCCGAGAATCTCAGACG
AGAAAGAAAGTAAATCATTCTCGAGGCACTGAGGTCTCAGAGCCATCTCCGCCCGTGAGA
GACCCTGAGGGGGTAACGCAGGCCCCTGGAGTGGAGCCCAGCAATGGCCTGGAGAAGCCT
GCACGGGAGCTGAACGGCAGCGAGGCCGCCACCCCGCGGGACTCACCCCGCCCCGGGAAG
CCAGACGAGAGGGACATCTGGCCCCCTGCCCAGGCCCCCACCAGCAGCCAAGAGCTGGCA
GGCGCTCCTGAGCCCCAGGGATCCTGTGCGCAGGGTGGCCGGGTGGCACCGGGACAGCGG
CCTGCCCAGGGTGCCACGGGCACTGACCTGGACTTTGACTTATCCAGCGACAGCGAGAGC
AGCAGTGAGTCCGAGGGCACGAAGTCCTCCTCCTCCGCCTCTGATGGCGAAAGCGAGGGG
AAAAGAGGCCGGCAGAAGCCGAAGGCTGCCCCAGAGGGAGCCGGGGCGCTGGCACAGGGC
AGTTCCCTGGAGCCGGGGCGGCCTGCAGCACCGAGTCTCCCCGGAGAGGCCGAGCCTGGC
GCGCATGCCCCGGACAAGGAGCCTGAGCTGGGTGGGCAGGAGGAGGGCGAGCGGGATGGC
CTCTGCGGCCTGGGCAACGGCTGTGCCGACAGGAAGGAGGCGGAGACCGAGTCACAGAAC
AGCGAGCTGTCGGGGGTCACTGCGGGTGAGTCCCTGGACCAGAGCATGGAGGAGGAGGAG
GAGGAGGACACGGATGAGGATGACCACCTCATCTACCTGGAGGAGATCCTGGTCCGTGTA
CACACTGACTACTATGCCAAGTATGACCGCTACCTCAACAAGGAGATCGAGGAGGCGCCG
GACATCCGCAAGATCGTGCCGGAGCTCAAGAGCAAGGTGCTGGCAGACGTGGCCATAATT
TTCAGTGGGCTACACCCGACAAACTTCCCGATAGAGAAGACGCGGGAGCATTACCACGCC
ACGGCGCTGGGAGCGAAGATCCTCACTCGGCTGGTGCTGAGCCCCGACGCCCCTGACAGG
GCCACGCACCTGATCGCCGCGCGAGCTGGCACAGAGAAGGTGCTGCAGGCACAGGAGTGC
GGACACCTGCACGTGGTCAACCCTGACTGGCTGTGGAGCTGCCTGGAGCGCTGGGACAAG
GTGGAGGAGCAGCTCTTCCCGCTCAGGGACGATCACACCAAGGCACAGAGGGAGAACAGC
CCTGCGGCCTTTCCCGACCGGGAGGGTGTGCCCCCCACCGCCTTGTTCCACCCGATGCCG
GTTCTTCCCAAGGCCCAGCCTGGCCCCGAGGTTCGGATCTACGACTCCAACACGGGGAAG
CTCATCAGGACGGGCGCCCGGGGGCCCCCAGCACCCTCCAGCTCCCTACCCATCCGCCAG
GAGCCCTCTTCCTTCAGAGCGGTTCCGCCACCCCAGCCGCAGATGTTTGGTGAAGAGCTG
CCTGACGCTCAGGACGGAGAGCAGCCTGGCCCTTCTAGAAGAAAGCGACAGCCCAGTATG
TCTGAGACAATGCCGCTGTACACTCTTTGTAAGGAGGATTTAGAGAGTATGGACAAAGAG
GTGGACGACATCCTTGGAGAAGGCAGCGACGACAGCGACAGCGAGAAGAGGAGGCCTGAG
GAGCAGGAGGAGGAGCCCCAGCCCCGGAAGCCAGGGACCCGCAGGGAGCGGACGCTCGGG
GCACCTGCGTCCAGCGAGAGGAGCGCGGCAGGGGGCCGGGGGCCCAGAGGCCACAAGAGG
AAGCTGAATGAAGAGGACGCCGCCAGCGAGTCCAGCAGGGAGTCCAGCAACGAGGATGAG
GGCAGCAGCTCCGAGGCCGACGAGATGGCCAAGGCGCTGGAGGCGGAGCTCAACGACCTC
ATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 961 |
| Molecular Weight
| 92376.475 |
| Theoretical pI
| 5.112 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>RNA polymerase II subunit A C-terminal domain phosphatase
MEVPAAGRVPAEGAPTAAVAEVRCPGPAPLRLLEWRVAAGAAVRIGSVLAVFEAAASAQS
AGASQSRVASGGCVRPARPERRLRSERAGVVRELCAQPGQVVAPGAVLVRLEGCSHPVVM
KGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRN
RKLVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLY
ELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDECIDPFSKTGNLRNLFPCGDSMVCI
IDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPGSRESQTRKKVNHSRGTEVSEPSPPVR
DPEGVTQAPGVEPSNGLEKPARELNGSEAATPRDSPRPGKPDERDIWPPAQAPTSSQELA
GAPEPQGSCAQGGRVAPGQRPAQGATGTDLDFDLSSDSESSSESEGTKSSSSASDGESEG
KRGRQKPKAAPEGAGALAQGSSLEPGRPAAPSLPGEAEPGAHAPDKEPELGGQEEGERDG
LCGLGNGCADRKEAETESQNSELSGVTAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRV
HTDYYAKYDRYLNKEIEEAPDIRKIVPELKSKVLADVAIIFSGLHPTNFPIEKTREHYHA
TALGAKILTRLVLSPDAPDRATHLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDK
VEEQLFPLRDDHTKAQRENSPAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGK
LIRTGARGPPAPSSSLPIRQEPSSFRAVPPPQPQMFGEELPDAQDGEQPGPSRRKRQPSM
SETMPLYTLCKEDLESMDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRGADAR
APASSERSAAGGRGPRGHKRKLNEEDAASESSRESSNEDEGSSSEADEMAKALEAELNDL
M
|
| External Links |
|---|
| GenBank ID Protein
| 67188445 |
| UniProtKB/Swiss-Prot ID
| Q9Y5B0 |
| UniProtKB/Swiss-Prot Entry Name
| CTDP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_004715.3 |
| GeneCard ID
| CTDP1 |
| GenAtlas ID
| CTDP1 |
| HGNC ID
| HGNC:2498 |
| References |
|---|
| General References
| Not Available |