Identification
HMDB Protein ID CDBP04102
Secondary Accession Numbers Not Available
Name Oxidoreductase HTATIP2
Description Not Available
Synonyms
  1. 30 kDa HIV-1 TAT-interacting protein
  2. HIV-1 TAT-interactive protein 2
Gene Name HTATIP2
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect
GO Classification
Component
cell part
intracellular part
cytoplasm
Function
binding
nucleotide binding
catalytic activity
nad or nadh binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors
oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
Process
metabolic process
cellular metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
Cellular Location
  1. Cytoplasm
  2. Nucleus envelope
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11p15.1
SNPs HTATIP2
Gene Sequence
>729 bp
ATGGCCGAAACAGAAGCCCTGTCGAAGCTTCGGGAAGACTTCAGGATGCAGAATAAATCC
GTCTTTATTTTGGGCGCCAGCGGAGAAACCGGCAGAGTGCTCTTAAAGGAAATCCTGGAG
CAGGGCCTGTTTTCCAAAGTCACGCTCATTGGCCGGAGGAAGCTCACCTTCGACGAGGAA
GCTTATAAAAATGTGAATCAAGAAGTGGTGGACTTTGAAAAGTTGGATGACTACGCCTCT
GCCTTTCAAGGTCATGATGTTGGATTCTGTTGCCTGGGTACCACCAGAGGGAAAGCTGGG
GCGGAGGGATTTGTTCGTGTTGACCGAGATTATGTGCTGAAGTCTGCAGAGCTGGCAAAA
GCTGGAGGGTGCAAACATTTCAACTTGCTATCCTCTAAAGGAGCTGATAAATCAAGCAAT
TTTTTATATCTACAAGTTAAGGGAGAAGTAGAAGCCAAGGTTGAAGAATTAAAATTTGAT
CGTTACTCTGTATTTAGGCCTGGAGTTCTGTTATGTGATAGGCAAGAATCTCGCCCAGGT
GAATGGCTGGTTAGAAAGTTCTTTGGCTCCTTACCAGACTCTTGGGCCAGTGGGCATTCT
GTGCCTGTGGTGACCGTGGTTAGAGCAATGCTGAACAATGTGGTGAGACCAAGAGACAAG
CAGATGGAACTGCTGGAGAACAAGGCCATCCATGACCTGGGGAAAGCGCATGGCTCTCTC
AAGCCATGA
Protein Properties
Number of Residues 242
Molecular Weight 27117.9
Theoretical pI 8.88
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Oxidoreductase HTATIP2
MAETEALSKLREDFRMQNKSVFILGASGETGRVLLKEILEQGLFSKVTLIGRRKLTFDEE
AYKNVNQEVVDFEKLDDYASAFQGHDVGFCCLGTTRGKAGAEGFVRVDRDYVLKSAELAK
AGGCKHFNLLSSKGADKSSNFLYLQVKGEVEAKVEELKFDRYSVFRPGVLLCDRQESRPG
EWLVRKFFGSLPDSWARGHSVPVVTVVRAMLNNVVRPRDKQMELLENKAIHDLGKAHGSL
KP
GenBank ID Protein 148728168
UniProtKB/Swiss-Prot ID Q9BUP3
UniProtKB/Swiss-Prot Entry Name HTAI2_HUMAN
PDB IDs
GenBank Gene ID NM_001098521.1
GeneCard ID HTATIP2
GenAtlas ID HTATIP2
HGNC ID HGNC:16637
References
General References Not Available