| Identification |
|---|
| HMDB Protein ID
| CDBP04100 |
| Secondary Accession Numbers
| Not Available |
| Name
| Thioredoxin domain-containing protein 2 |
| Description
| Not Available |
| Synonyms
|
- Spermatid-specific thioredoxin-1
- Sptrx-1
|
| Gene Name
| TXNDC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nutrient reservoir activity |
| Specific Function
| Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase |
| GO Classification
|
| Process |
| cellular process |
| cellular homeostasis |
| cell redox homeostasis |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| TXNDC2 |
| Gene Sequence
|
>1662 bp
ATGGATGTAGACAAGGAACTAGGAATGGAAAGTGTTAAAGCTGGAGCCTCTGGAAAACCA
GAAATGAGGCTGGGCACTCAGGAAGAAACAAGTGAAGGTGATGCTAATGAAAGCTCATTA
CTAGTCCTGTCCAGCAACGTGCCTCTCCTGGCCCTAGAGTTCTTGGAAATAGCCCAGGCC
AAAGAGAAGGCCTTTCTCCCCATGGTCAGCCACACGTTCCACATGCGCACAGAGGAGTCT
GATGCCTCACAGGAGGGCGATGACCTACCCAAGTCCTCAGCAAACACCAGCCATCCCAAG
CAGGATGACAGCCCCAAGTCCTCAGAAGAAACCATCCAGCCCAAGGAGGGTGACATCCCC
AAGGCCCCAGAAGAAACCATCCAATCCAAGAAGGAGGACCTCCCCAAGTCCTCAGAAAAA
GCCATCCAGCCCAAAGAGAGTAACATCCCCAAGTCCTCAGCAAAACCCATCCAGCCCAAG
CTGGGCAATATTCCCAAGGCCTCAGTGAAGCCCAGCCAGCCCAAGGAGGGTGACATCCCC
AAGGCCCCAGAAGAAACCATCCAATCCAAGAAGGAGGACCTCCCCAAGTCCTCAGAAGAA
GCCATCCAGCCCAAAGAGGGTGACATCCCCAAGTCCTCAGCAAAACCCATCCAGCCCAAG
CTGGGCAATATTGCCAAGACCTCAGTGAAGCCCAGCCAGCCCAAGGAGAGTGATATCCCC
AAGTCCCCAGAAGAAACCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCTCAGCAAAG
CCCATCCAGCCCAAGCTGGGCAATATTCCCAAGGCCTCAGTGAAGCCCAGCCAGCCCAAG
GAGGGTGACATCTCCAAGTCCCCAGAAGAAGCCATCCAGCCCAAGGAGGGTGACCTCCCC
AAGTCCCTAGAGGAAGCCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCCCAGAAGAA
GCCATCCAGCCCAAGGAGGGTGACATCCCCAAGTCCCTAGAGGAAGCCATCCAGCCTAAG
GAGGGTGACATCCCCAAGTCCCCAGAAGAAACCATCCAGCCCAAGAAGGGTGACATCCCC
AAGTCCCCAGAAGAAGCCATCCAGCCCAAGGAGGGTGACATTCCCAAGTCTCCAAAACAA
GCCATCCAGCCCAAGGAGGGTGACATTCCCAAGTCCCTAGAGGAAGCCATCCCACCCAAG
GAGATTGACATCCCCAAGTCCCCAGAAGAAACCATCCAGCCCAAGGAGGATGACAGCCCC
AAGTCCCTAGAAGAAGCCACCCCATCCAAGGAGGGTGACATCCTAAAGCCTGAAGAAGAA
ACAATGGAGTTCCCGGAGGGGGACAAGGTGAAAGTGATCCTGAGCAAGGAGGACTTTGAG
GCATCACTGAAGGAGGCCGGGGAGAGGCTGGTGGCTGTGGACTTCTCGGCCACGTGGTGT
GGGCCCTGCAGGACCATCAGACCATTCTTCCATGCCCTGTCTGTGAAGCATGAGGATGTG
GTGTTCCTGGAGGTGGACGCTGACAACTGTGAGGAGGTGGTGAGAGAGTGCGCCATCATG
TGTGTCCCAACCTTTCAGTTTTATAAAAAAGAAGAAAAGGTGGATGAACTTTGCGGCGCC
CTTAAGGAAAAACTTGAAGCAGTCATTGCAGAATTAAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 553 |
| Molecular Weight
| 60461.5 |
| Theoretical pI
| 4.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Thioredoxin domain-containing protein 2
MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQA
KEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP
KAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIP
KAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIP
KSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLP
KSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKDDIP
KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSP
KSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWC
GPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGA
LKEKLEAVIAELK
|
| External Links |
|---|
| GenBank ID Protein
| 148727319 |
| UniProtKB/Swiss-Prot ID
| Q86VQ3 |
| UniProtKB/Swiss-Prot Entry Name
| TXND2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001098529.1 |
| GeneCard ID
| TXNDC2 |
| GenAtlas ID
| TXNDC2 |
| HGNC ID
| HGNC:16470 |
| References |
|---|
| General References
| Not Available |