Identification |
HMDB Protein ID
| CDBP04075 |
Secondary Accession Numbers
| Not Available |
Name
| Nucleoredoxin |
Description
| Not Available |
Synonyms
|
Not Available
|
Gene Name
| NXN |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in antioxidant activity |
Specific Function
| Functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A |
GO Classification
|
Function |
catalytic activity |
antioxidant activity |
oxidoreductase activity |
Process |
cellular process |
cellular homeostasis |
cell redox homeostasis |
|
Cellular Location
|
- Nucleus
- Cytoplasm
- cytosol
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 17p13.3 |
SNPs
| NXN |
Gene Sequence
|
>1308 bp
ATGTCGGGCTTCCTGGAGGAGCTGCTCGGCGAGAAGCTGGTGACGGGCGGCGGCGAGGAG
GTGGACGTGCACTCGCTGGGCGCCCGCGGCATCTCGCTGCTGGGTCTCTACTTCGGCTGC
AGCCTCAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGGCGCCTG
CGGGGGGACGCGGCGGCCGGGCCGGGGCCGGGAGCGGGGGCCGGGGCGGCGGCGGAGCCC
GAGCCGCGGCGGCGCCTGGAGATCGTCTTCGTGTCCTCGGACCAGGACCAGCGGCAGTGG
CAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTGCCCTACAAGGAGAAGCACAGGAAG
CTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCC
ACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGT
CTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGA
AACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTC
TCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGG
AAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAG
GAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAG
GCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATG
CTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAG
GACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCC
GCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAG
TCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAA
GCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGAC
TCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATG
TCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCC
TTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAG
|
Protein Properties |
Number of Residues
| 435 |
Molecular Weight
| 48391.6 |
Theoretical pI
| 4.6 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Nucleoredoxin
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRL
RGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRK
LKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLR
NNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSE
ESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDE
DCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYK
AKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA
FVNDFLAEKLKPEPI
|
External Links |
GenBank ID Protein
| 33149331 |
UniProtKB/Swiss-Prot ID
| Q6DKJ4 |
UniProtKB/Swiss-Prot Entry Name
| NXN_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_022463.3 |
GeneCard ID
| NXN |
GenAtlas ID
| NXN |
HGNC ID
| HGNC:18008 |
References |
General References
| Not Available |