Identification
HMDB Protein ID CDBP04075
Secondary Accession Numbers Not Available
Name Nucleoredoxin
Description Not Available
Synonyms Not Available
Gene Name NXN
Protein Type Enzyme
Biological Properties
General Function Involved in antioxidant activity
Specific Function Functions as a redox-dependent negative regulator of the Wnt signaling pathway. May function as a transcriptional regulator. May regulate phosphatase 2A
GO Classification
Function
catalytic activity
antioxidant activity
oxidoreductase activity
Process
cellular process
cellular homeostasis
cell redox homeostasis
Cellular Location
  1. Nucleus
  2. Cytoplasm
  3. cytosol
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 17p13.3
SNPs NXN
Gene Sequence
>1308 bp
ATGTCGGGCTTCCTGGAGGAGCTGCTCGGCGAGAAGCTGGTGACGGGCGGCGGCGAGGAG
GTGGACGTGCACTCGCTGGGCGCCCGCGGCATCTCGCTGCTGGGTCTCTACTTCGGCTGC
AGCCTCAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGGCGCCTG
CGGGGGGACGCGGCGGCCGGGCCGGGGCCGGGAGCGGGGGCCGGGGCGGCGGCGGAGCCC
GAGCCGCGGCGGCGCCTGGAGATCGTCTTCGTGTCCTCGGACCAGGACCAGCGGCAGTGG
CAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTGCCCTACAAGGAGAAGCACAGGAAG
CTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCC
ACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAGGT
CTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGA
AACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTC
TCCGCACATTGGTGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGG
AAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAGGTCGGAG
GAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAG
GCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAGGCATCCCCACGCTCATCATG
CTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAG
GACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCC
GCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAGATTCTGAGGATGACGGAGAG
TCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAA
GCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAGGATGACATGACTGAC
TCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATG
TCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCC
TTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAG
Protein Properties
Number of Residues 435
Molecular Weight 48391.6
Theoretical pI 4.6
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Nucleoredoxin
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRL
RGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRK
LKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLR
NNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSE
ESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDE
DCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYK
AKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA
FVNDFLAEKLKPEPI
GenBank ID Protein 33149331
UniProtKB/Swiss-Prot ID Q6DKJ4
UniProtKB/Swiss-Prot Entry Name NXN_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022463.3
GeneCard ID NXN
GenAtlas ID NXN
HGNC ID HGNC:18008
References
General References Not Available