| Identification |
|---|
| HMDB Protein ID
| CDBP04064 |
| Secondary Accession Numbers
| Not Available |
| Name
| Serine/threonine-protein kinase SMG1 |
| Description
| Not Available |
| Synonyms
|
- 61E3.4
- Lambda-interacting protein
- Lambda/iota protein kinase C-interacting protein
- SMG-1
- hSMG-1
|
| Gene Name
| SMG1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Acts as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, it phosphorylates UPF1/RENT1, triggering nonsense-mediated decay (NMD). Also acts as a genotoxic stress- activated protein kinase that displays some functional overlap with ATM. Can phosphorylate TP53/p53 and is required for optimal TP53/p53 activation after cellular exposure to genotoxic stress. Its depletion leads to spontaneous DNA damage and increased sensitivity to ionizing radiation (IR). May activate PRKCI but not PRKCZ |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| phosphotransferase activity, alcohol group as acceptor |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16p12.3 |
| SNPs
| SMG1 |
| Gene Sequence
|
>10974 bp
ATGAGCCGCAGAGCCCCGGGGTCTCGGCTGAGCAGCGGCGGCACCAACTATTCGCGGAGC
TGGAATGACTGGCAACCCAGAACTGATAGTGCATCAGCTGACCCAGGTAATTTAAAATAT
TCTTCATCCAGAGATAGAGGTGGTTCTTCCTCTTACGGACTGCAACCTTCAAATTCAGCT
GTGGTGTCTCGGCAAAGGCACGATGATACCAGAGTCCACGCTGACATACAGAATGACGAA
AAGGGTGGCTACAGTGTCAATGGAGGATCTGGGGAAAATACTTATGGTCGGAAGTCGTTG
GGGCAAGAGCTGAGGGTTAACAATGTGACCAGCCCTGAGTTCACCAGTGTTCAGCATGGC
AGTCGTGCTTTAGCCACCAAAGACATGAGGAAATCACAGGAGAGATCGATGTCTTATTCT
GATGAGTCTCGACTGTCGAATCTTCTTCGGAGGATCACCCGGGAAGACGACAGAGACCGA
AGATTGGCTACTGTAAAGCAGTTGAAAGAATTTATTCAGCAACCAGAAAATAAGCTGGTA
CTAGTTAAACAATTGGATAATATCTTGGCTGCTGTACATGACGTGCTTAATGAAAGTAGC
AAATTGCTTCAGGAGTTGAGACAGGAGGGAGCTTGCTGTCTTGGCCTTCTTTGTGCTTCT
CTGAGCTATGAGGCTGAGAAGATCTTCAAGTGGATTTTTAGCAAATTTAGCTCATCTGCA
AAAGATGAAGTTAAACTCCTCTACTTATGTGCCACCTACAAAGCACTAGAGACTGTAGGA
GAAAAGAAAGCCTTTTCATCTGTAATGCAGCTTGTAATGACCAGCCTGCAGTCTATTCTT
GAAAATGTGGATACACCAGAATTGCTTTGTAAATGTGTTAAGTGCATTCTTTTGGTGGCT
CGATGTTACCCTCATATTTTCAGCACTAATTTTAGGGATACAGTTGATATATTAGTTGGA
TGGCATATAGATCATACTCAGAAACCTTCGCTCACGCAGCAGGTATCTGGGTGGTTGCAG
AGTTTGGAGCCATTTTGGGTAGCTGATCTTGCATTTTCTACTACTCTTCTTGGTCAGTTT
CTGGAAGACATGGAAGCATATGCTGAGGACCTCAGCCATGTGGCCTCTGGGGAATCAGTG
GATGAAGATGTCCCTCCTCCATCAGTGTCATTACCAAAGCTGGCTGCACTTCTCCGGGTA
TTTAGTACTGTGGTGAGGAGCATTGGGGAACGCTTCAGCCCAATTCGGGGTCCTCCAATT
ACTGAGGCATATGTAACAGATGTTCTGTACAGAGTAATGAGATGTGTGACGGCTGCAAAC
CAGGTGTTTTTTTCTGAGGCTGTGTTGACAGCTGCTAATGAGTGTGTTGGTGTTTTGCTC
GGCAGCTTGGATCCTAGCATGACTATACATTGTGACATGGTCATTACATATGGATTAGAC
CAACTGGAGAATTGCCAGACTTGTGGTACCGATTATATCATCTCAGTCTTGAATTTACTC
ACGCTGATTGTTGAACAGATAAATACGAAACTGCCATCATCATTTGTAGAAAAACTGTTT
ATACCATCATCTAAACTACTATTCTTGCGTTATCATAAAGAAAAAGAGGTTGTTGCTGTA
GCCCATGCTGTTTATCAAGCAGTGCTCAGCTTGAAGAATATTCCTGTTTTGGAGACTGCC
TATAAGTTAATATTGGGAGAAATGACTTGTGCCCTAAACAACCTCCTACACAGTCTACAA
CTTCCTGAGGCCTGTTCTGAAATAAAACATGAGGCTTTTAAGAATCATGTGTTCAATGTA
GACAATGCAAAATTTGTAGTTAAATTTGACCTCAGTGCCCTGACTACAATTGGAAATGCC
AAAAACTCACTAATAGGGATGTGGGCGCTATCTCCAACTGTCTTTGCACTTCTGAGTAAG
AATCTGATGATTGTGCACAGTGACCTGGCTGTTCACTTCCCTGCCATTCAGTATGCTGTG
CTCTACACATTGTATTCTCATTGTACCAGGCATGATCACTTTATCTCTAGTAGCCTCAGT
TCTGCCTCTCCTTCTTTGTTTGATGGAGCTGTGATTAGCACTGTAACTACGGCTACAAAG
AAACATTTCTCAATTATATTAAATCTTCTGGGAATATTACTTAAGAAAGATAACCTTAAC
CAGGACACGAGGAAACTGTTAATGACTTGGGCTTTGGAAGCAGCTGTTTTAATGAGGAAG
TCTGAAACATACGCACCTTTATTCTCTCTTCCGTCTTTCCATAAATTTTGCAAAGGCCTT
TTAGCCAACACTCTCGTTGAAGATGTGAATATCTGTCTGCAGGCATGCAGCAGTCTACAT
GCTCTGTCCTCTTCCTTGCCAGATGATCTTTTACAGAGATGTGTCGATGTTTGCCGTGTT
CAACTAGTGCACAGTGGAACTCGTATTCGACAAGCATTTGGAAAACTGTTGAAATCAATT
CCTTTAGATGTTGTCCTAAGCAATAACAATCACACAGAAATTCAAGAAATTTCTTTAGCA
TTAAGAAGTCACATGAGTAAAGCACCAAGTAATACATTCCACCCCCAAGATTTCTCTGAT
GTTATTAGTTTTATTTTGTATGGGAACTCTCATAGAACAGGGAAGGACAATTGGTTGGAA
AGACTGTTCTATAGCTGCCAGAGACTGGATAAGCGTGACCAGTCAACAATTCCACGCAAT
CTCCTGAAGACAGATGCTGTCCTTTGGCAGTGGGCCATATGGGAAGCTGCACAATTCACT
GTTCTTTCTAAGCTGAGAACCCCACTGGGCAGAGCTCAAGACACCTTCCAGACAATTGAA
GGTATCATTCGAAGTCTCGCAGCTCACACATTAAACCCTGATCAGGATGTTAGTCAGTGG
ACAACTGCAGACAATGATGAAGGCCATGGTAACAACCAACTTAGACTTGTTCTTCTTCTG
CAGTATCTGGAAAATCTGGAGAAATTAATGTATAATGCATACGAGGGATGTGCTAATGCA
TTAACTTCACCTCCCAAGGTCATTAGAACTTTTTTCTATACCAATCGCCAAACTTGTCAG
GACTGGCTAACGCGGATTCGACTCTCCATCATGAGGGTAGGATTGTTGGCAGGCCAGCCT
GCAGTGACAGTGAGACATGGCTTTGACTTGCTTACAGAGATGAAAACAACCAGCCTATCT
CAGGGGAATGAATTGGAAGTAACCATTATGATGGTGGTAGAAGCATTATGTGAACTTCAT
TGTCCTGAAGCTATACAGGGAATTGCTGTCTGGTCATCATCTATTGTTGGAAAAAATCTT
CTGTGGATTAACTCAGTGGCTCAACAGGCTGAAGGGAGGTTTGAAAAGGCCTCTGTGGAG
TACCAGGAACACCTGTGTGCCATGACAGGTGTTGATTGCTGCATCTCCAGCTTTGACAAA
TCGGTGCTCACCTTAGCCAATGCTGGGCGTAACAGTGCCAGCCCGAAACATTCTCTGAAT
GGTGAATCCAGAAAAACTGTGCTGTCCAAACCGACTGACTCTTCCCCTGAGGTTATAAAT
TATTTAGGAAATAAAGCATGTGAGTTCTACATCTCAATTGCCGATTGGGCTGCTGTGCAG
GAATGGCAGAACGCTATCCATGACTTGAAAAAGAGTACCAGTAGCACTTCCCTCAACCTG
AAAGCTGACTTCAACTATATAAAATCATTAAGCAGCTTTGAGTCTGGAAAATTTGTTGAA
TGTACCGAGCAGTTAGAATTGTTACCAGGAGAAAATATCAATCTACTTGCTGGAGGATCA
AAAGAAAAAATAGACATGAAAAAACTGCTTCCTAACATGTTAAGTCCGGATCCGAGGGAA
CTTCAGAAATCCATTGAAGTTCAATTGTTAAGAAGTTCTGTTTGTTTGGCAACTGCTTTA
AACCCGATAGAACAAGATCAGAAGTGGCAGTCTATAACTGAAAATGTGGTAAAGTACTTG
AAGCAAACATCCCGCATCGCTATTGGACCTCTGAGACTTTCTACTTTAACAGTTTCACAG
TCTTTGCCAGTTCTAAGTACCTTGCAGCTGTATTGCTCATCTGCTTTGGAGAACACAGTT
TCTAACAGACTTTCAACAGAGGACTGTCTTATTCCACTCTTCAGTGAAGCTTTACGTTCA
TGTAAACAGCATGACGTGAGGCCATGGATGCAGGCATTAAGGTATACTATGTACCAGAAT
CAGTTGTTGGAGAAAATTAAAGAACAAACAGTCCCAATTAGAAGCCATCTCATGGAATTA
GGTCTAACAGCAGCAAAATTTGCTAGAAAACGAGGGAATGTGTCCCTTGCAACAAGACTG
CTGGCACAGTGCAGTGAAGTTCAGCTGGGAAAGACCACCACTGCACAGGATTTAGTCCAA
CATTTTAAAAAACTATCAACCCAAGGTCAAGTGGATGAAAAATGGGGGCCCGAACTTGAT
ATTGAAAAAACCAAATTGCTTTATACAGCAGGCCAGTCAACACATGCAATGGAAATGTTG
AGTTCTTGTGCCATATCTTTCTGCAAGTCTGTGAAAGCTGAATATGCAGTTGCTAAATCA
ATTCTGACACTGGCTAAATGGATCCAGGCAGAATGGAAAGAGATTTCAGGACAGCTGAAA
CAGGTTTACAGAGCTCAGCACCAACAGAACTTCACAGGTCTTTCTACTTTGTCTAAAAAC
ATACTCACTCTAATAGAACTGCCATCTGTTAATACGATGGAAGAAGAGTATCCTCGGATC
GAGAGTGAATCTACAGTGCATATTGGAGTTGGAGAACCTGACTTCATTTTGGGACAGTTG
TATCACCTGTCTTCAGTACAGGCACCTGAAGTAGCCAAATCTTGGGCAGCGTTGGCCAGC
TGGGCTTATAGGTGGGGCAGAAAGGTGGTTGACAATGCCAGTCAGGGAGAAGGTGTTCGT
CTGCTGCCTAGAGAAAAATCTGAAGTTCAGAATCTACTTCCAGACACTATAACTGAGGAA
GAGAAAGAGAGAATATATGGTATTCTTGGACAGGCTGTGTGTCGGCCGGCGGGGATTCAG
GATGAAGATATAACACTTCAGATAACTGAGAGTGAAGACAACGAAGAAGATGACATGGTT
GATGTTATCTGGCGTCAGTTGATATCAAGCTGCCCATGGCTTTCAGAACTTGATGAAAGT
GCAACTGAAGGAGTTATTAAAGTGTGGAGGAAAGTTGTAGATAGAATATTCAGCCTGTAC
AAACTCTCTTGCAGTGCATACTTTACTTTCCTTAAACTCAACGCTGGTCAAATTCCTTTA
GATGAGGATGACCCTAGGCTGCATTTAAGTCACAGAGTGGAACAGAGCACTGATGACATG
ATTGTGATGGCCACATTGCGCCTGCTGCGGTTGCTCGTGAAGCATGCTGGTGAGCTTCGG
CAGTATCTGGAGCACGGCTTGGAGACAACACCCACTGCACCATGGAGGGGAATTATTCCG
CAACTTTTCTCACGCTTAAACCACCCTGAAGTGTATGTGCGCCAAAGTATTTGTAACCTT
CTCTGCCGTGTGGCTCAAGATTCCCCACATCTCATATTGTATCCTGCAATAGTGGGTACC
ATATCGCTTAGTAGTGAATCCCAGGCTTCAGGAAATAAATTTTCCACTGCAATTCCAACT
TTACTTGGCAATATTCAAGGAGAAGAATTGCTGGTTTCTGAATGTGAGGGAGGAAGTCCT
CCTGCATCTCAGGATAGCAATAAGGATGAACCTAAAAGTGGATTAAATGAAGACCAAGCC
ATGATGCAGGATTGTTACAGCAAAATTGTAGATAAGCTGTCCTCTGCAAACCCCACCATG
GTATTACAGGTTCAGATGCTCGTGGCTGAACTGCGCAGGGTCACTGTGCTCTGGGATGAG
CTCTGGCTGGGAGTTTTGCTGCAACAACACATGTATGTCCTGAGACGAATTCAGCAGCTT
GAAGATGAGGTGAAGAGAGTCCAGAACAACAACACCTTACGCAAAGAAGAGAAAATTGCA
ATCATGAGGGAGAGGCACACAGCTTTGATGAAGCCCATCGTATTTGCTTTGGAGCATGTG
AGGAGTATCACAGCGGCTCCTGCAGAAACACCTCATGAAAAATGGTTTCAGGATAACTAT
GGTGATGCCATTGAAAATGCCCTAGAAAAACTGAAGACTCCATTGAACCCTGCAAAGCCT
GGGAGCAGCTGGATTCCATTTAAAGAGATAATGCTAAGTTTGCAACAGAGAGCACAGAAA
CGTGCAAGTTACATCTTGCGTCTTGAAGAAATCAGTCCATGGTTGGCTGCCATGACTAAC
ACTGAAATTGCTCTTCCTGGGGAAGTCTCAGCCAGAGACACTGTCACAATCCATAGTGTG
GGCGGAACCATCACAATCTTACCGACTAAAACCAAGCCAAAGAAACTTCTCTTTCTTGGA
TCAGATGGGAAGAGCTATCCTTATCTTTTCAAAGGACTGGAGGATTTACATCTGGATGAG
AGAATAATGCAGTTCCTATCTATTGTGAATACCATGTTTGCTACAATTAATCGCCAAGAA
ACACCCCGGTTCCATGCTCGACACTATTCTGTAACACCACTAGGAACAAGATCAGGACTA
ATCCAGTGGGTAGATGGAGCCACACCCTTATTTGGTCTTTACAAACGATGGCAACAACGG
GAAGCTGCCTTACAAGCACAAAAGGCCCAAGATTCCTACCAAACTCCTCAGAATCCTGGA
ATTGTACCCCGTCCTAGTGAACTTTATTACAGTAAAATTGGCCCTGCTTTGAAAACAGTT
GGGCTTAGCCTGGATGTGTCCCGTCGGGATTGGCCTCTTCATGTAATGAAGGCAGTATTG
GAAGAGTTAATGGAGGCCACACCCCCGAATCTCCTTGCCAAAGAGCTCTGGTCATCTTGC
ACAACACCTGATGAATGGTGGAGAGTTACGCAGTCTTATGCAAGATCTACTGCAGTCATG
TCTATGGTTGGATACATAATTGGCCTTGGAGACAGACATCTGGATAATGTTCTTATAGAT
ATGACGACTGGAGAAGTTGTTCACATAGATTACAATGTTTGCTTTGAAAAAGGTAAAAGC
CTTAGAGTTCCTGAGAAAGTACCTTTTCGAATGACACAAAACATTGAAACAGCACTGGGT
GTAACTGGAGTAGAAGGTGTATTTAGGCTTTCATGTGAGCAGGTTTTACACATTATGCGG
CGTGGCAGAGAGACCCTGCTGACGCTGCTGGAGGCCTTTGTGTACGACCCTCTGGTGGAC
TGGACAGCAGGAGGCGAGGCTGGGTTTGCTGGTGCTGTCTATGGTGGAGGTGGCCAGCAG
GCCGAGAGCAAGCAGAGCAAGAGAGAGATGGAGCGAGAGATCACCCGCAGCCTGTTTTCT
TCTAGAGTAGCTGAGATTAAGGTGAACTGGTTTAAGAATAGAGATGAGATGCTGGTTGTG
CTTCCCAAGTTGGACGGTAGCTTAGATGAATACCTAAGCTTGCAAGAGCAACTGACAGAT
GTGGAAAAACTGCAGGGCAAACTACTGGAGGAAATAGAGTTTCTAGAAGGAGCTGAAGGG
GTGGATCATCCTTCTCATACTCTGCAACACAGGTATTCTGAGCACACCCAACTACAGACT
CAGCAAAGAGCTGTTCAGGAAGCAATCCAGGTGAAGCTGAATGAATTTGAACAATGGATA
ACACATTATCAGGCTGCATTCAATAATTTAGAAGCAACACAGCTTGCAAGCTTGCTTCAA
GAGATAAGCACACAAATGGACCTTGGTCCTCCAAGTTACGTGCCAGCAACAGCCTTTCTG
CAGAATGCTGGTCAGGCCCACTTGATTAGCCAGTGCGAGCAGCTGGAGGGGGAGGTTGGT
GCTCTCCTGCAGCAGAGGCGCTCCGTGCTCCGTGGCTGTCTGGAGCAACTGCATCACTAT
GCAACCGTGGCCCTGCAGTATCCGAAGGCCATATTTCAGAAACATCGAATTGAACAGTGG
AAGACCTGGATGGAAGAGCTCATCTGTAACACCACAGTAGAGCGTTGTCAAGAGCTCTAT
AGGAAATATGAAATGCAATATGCTCCCCAGCCACCCCCAACAGTGTGTCAGTTCATCACT
GCCACTGAAATGACCCTGCAGCGATACGCAGCAGACATCAACAGCAGACTTATTAGACAA
GTGGAACGCTTGAAACAGGAAGCTGTCACTGTGCCAGTTTGTGAAGATCAGTTGAAAGAA
ATTGAACGTTGCATTAAAGTTTTCCTTCATGAGAATGGAGAAGAAGGATCTTTGAGTCTA
GCAAGTGTTATTATTTCTGCCCTTTGTACCCTTACAAGGCGTAACCTGATGATGGAAGGT
GCAGCGTCAAGTGCTGGAGAACAGCTGGTTGATCTGACTTCTCGGGATGGAGCCTGGTTC
TTGGAGGAACTCTGCAGTATGAGCGGAAACGTCACCTGCTTGGTTCAGTTACTGAAGCAG
TGCCACCTGGTGCCACAGGACTTAGATATCCCGAACCCCATGGAAGCGTCTGAGACAGTT
CACTTAGCCAATGGAGTGTATACCTCACTTCAGGAATTGAATTCGAATTTCCGGCAAATC
ATATTTCCAGAAGCACTTCGATGTTTAATGAAAGGGGAATACACGTTAGAAAGTATGCTG
CATGAACTGGACGGTCTTATTGAGCAGACCACCGATGGCGTTCCCCTGCAGACTCTAGTG
GAATCTCTTCAGGCCTACTTAAGAAACGCAGCTATGGGACTGGAAGAAGAAACACATGCT
CATTACATCGATGTTGCCAGACTACTACATGCTCAGTACGGTGAATTAATCCAACCGAGA
AATGGTTCAGTTGATGAAACACCCAAAATGTCAGCTGGCCAGATGCTTTTGGTAGCATTC
GATGGCATGTTTGCTCAAGTTGAAACTGCTTTCAGCTTATTAGTTGAAAAGTTGAACAAG
ATGGAAATTCCCATAGCTTGGCGAAAGATTGACATCATAAGGGAAGCCAGGAGTACTCAA
GTTAATTTTTTTGATGATGATAATCACCGGCAGGTGCTAGAAGAGATTTTCTTTCTAAAA
AGACTACAGACTATTAAGGAGTTCTTCAGGCTCTGTGGTACCTTTTCTAAAACATTGTCA
GGATCAAGTTCACTTGAAGATCAGAATACTGTGAATGGGCCTGTACAGATTGTCAATGTG
AAAACCCTTTTTAGAAACTCTTGTTTCAGTGAAGACCAAATGGCCAAACCTATCAAGGCA
TTCACAGCTGACTTTGTGAGGCAGCTCTTGATAGGGCTACCCAACCAAGCCCTCGGACTC
ACACTGTGCAGTTTTATCAGTGCTCTGGGTGTAGACATCATTGCTCAAGTAGAGGCAAAG
GACTTTGGTGCCGAAAGCAAAGTTTCTGTTGATGATCTCTGTAAGAAAGCGGTGGAACAT
AACATCCAGATAGGGAAGTTCTCTCAGCTGGTTATGAACAGGGCAACTGTGTTAGCAAGT
TCTTACGACACTGCCTGGAAGAAGCATGACTTGGTGCGAAGGCTAGAAACCAGTATTTCT
TCTTGTAAGACAAGCCTGCAGCGGGTTCAGCTGCATATTGCCATGTTTCAGTGGCAACAT
GAAGATCTACTTATCAATAGACCACAAGCCATGTCAGTCACACCTCCCCCACGGTCTGCT
ATCCTAACCAGCATGAAAAAGAAGCTGCATACCCTGAGCCAGATTGAAACTTCTATTGCG
ACAGTTCAGGAGAAGCTAGCTGCACTTGAATCAAGTATTGAACAGCGACTCAAGTGGGCA
GGTGGTGCCAACCCTGCATTGGCCCCTGTACTACAAGATTTTGAAGCAACGATAGCTGAA
AGAAGAAATCTTGTCCTTAAAGAGAGCCAAAGAGCAAGTCAGGTCACATTTCTCTGCAGC
AATATCATTCATTTTGAAAGTTTACGAACAAGAACTGCAGAAGCCTTAAACCTGGATGCG
GCGTTATTTGAACTAATCAAGCGATGTCAGCAGATGTGTTCGTTTGCATCACAGTTTAAC
AGTTCAGTGTCTGAGTTAGAGCTTCGTTTATTACAGAGAGTGGACACTGGTCTTGAACAT
CCTATTGGCAGCTCTGAATGGCTTTTGTCAGCACACAAACAGTTGACCCAGGATATGTCT
ACTCAGAGGGCAATTCAGACAGAGAAAGAGCAGCAGATAGAAACGGTCTGTGAAACAATT
CAGAATCTGGTTGATAATATAAAGACTGTGCTCACTGGTCATAACCGACAGCTTGGAGAT
GTCAAACATCTCTTGAAAGCTATGGCTAAGGATGAAGAAGCTGCTCTGGCAGATGGTGAA
GATGTTCCCTATGAGAACAGTGTTAGGCAGTTTTTGGGTGAATATAAATCATGGCAAGAC
AACATTCAAACAGTTCTATTTACATTAGTCCAGGCTATGGGTCAGGTTCGAAGTCAAGAA
CACGTTGAAATGCTCCAGGAAATCACTCCCACCTTGAAAGAACTGAAAACACAAAGTCAG
AGTATCTATAATAATTTAGTGAGTTTTGCATCACCCTTAGTCACCGATGCAACAAATGAA
TGTTCGAGTCCAACGTCATCTGCTACTTATCAGCCATCCTTCGCTGCAGCAGTCCGGAGT
AACACTGGCCAGAAGACTCAGCCTGATGTCATGTCACAGAATGCTAGAAAGCTGATCCAG
AAAAATCTTGCTACATCAGCTGATACTCCACCAAGCACCGTTCCAGGAACTGGCAAGAGT
GTTGCTTGTAGTCCTAAAAAGGCAGTCAGAGACCCTAAAACTGGGAAAGCGGTGCAAGAG
AGAAACTCCTATGCAGTGAGTGTGTGGAAGAGAGTGAAAGCCAAGTTAGAGGGCCGAGAT
GTTGATCCGAATAGGAGGATGTCAGTTGCTGAACAGGTTGACTATGTCATTAAGGAAGCA
ACTAATCTAGATAACTTGGCTCAGCTGTATGAAGGTTGGACAGCCTGGGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 3657 |
| Molecular Weight
| 410257.6 |
| Theoretical pI
| 6.43 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine/threonine-protein kinase SMG1
MSRRAPGSRLSSGGTNYSRSWNDWQPRTDSASADPGNLKYSSSRDRGGSSSYGLQPSNSA
VVSRQRHDDTRVHADIQNDEKGGYSVNGGSGENTYGRKSLGQELRVNNVTSPEFTSVQHG
SRALATKDMRKSQERSMSYSDESRLSNLLRRITREDDRDRRLATVKQLKEFIQQPENKLV
LVKQLDNILAAVHDVLNESSKLLQELRQEGACCLGLLCASLSYEAEKIFKWIFSKFSSSA
KDEVKLLYLCATYKALETVGEKKAFSSVMQLVMTSLQSILENVDTPELLCKCVKCILLVA
RCYPHIFSTNFRDTVDILVGWHIDHTQKPSLTQQVSGWLQSLEPFWVADLAFSTTLLGQF
LEDMEAYAEDLSHVASGESVDEDVPPPSVSLPKLAALLRVFSTVVRSIGERFSPIRGPPI
TEAYVTDVLYRVMRCVTAANQVFFSEAVLTAANECVGVLLGSLDPSMTIHCDMVITYGLD
QLENCQTCGTDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAV
AHAVYQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNV
DNAKFVVKFDLSALTTIGNAKNSLIGMWALSPTVFALLSKNLMIVHSDLAVHFPAIQYAV
LYTLYSHCTRHDHFISSSLSSASPSLFDGAVISTVTTATKKHFSIILNLLGILLKKDNLN
QDTRKLLMTWALEAAVLMRKSETYAPLFSLPSFHKFCKGLLANTLVEDVNICLQACSSLH
ALSSSLPDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSIPLDVVLSNNNHTEIQEISLA
LRSHMSKAPSNTFHPQDFSDVISFILYGNSHRTGKDNWLERLFYSCQRLDKRDQSTIPRN
LLKTDAVLWQWAIWEAAQFTVLSKLRTPLGRAQDTFQTIEGIIRSLAAHTLNPDQDVSQW
TTADNDEGHGNNQLRLVLLLQYLENLEKLMYNAYEGCANALTSPPKVIRTFFYTNRQTCQ
DWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQGNELEVTIMMVVEALCELH
CPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQEHLCAMTGVDCCISSFDK
SVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINYLGNKACEFYISIADWAAVQ
EWQNAIHDLKKSTSSTSLNLKADFNYIKSLSSFESGKFVECTEQLELLPGENINLLAGGS
KEKIDMKKLLPNMLSPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENVVKYL
KQTSRIAIGPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALRS
CKQHDVRPWMQALRYTMYQNQLLEKIKEQTVPIRSHLMELGLTAAKFARKRGNVSLATRL
LAQCSEVQLGKTTTAQDLVQHFKKLSTQGQVDEKWGPELDIEKTKLLYTAGQSTHAMEML
SSCAISFCKSVKAEYAVAKSILTLAKWIQAEWKEISGQLKQVYRAQHQQNFTGLSTLSKN
ILTLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAALAS
WAYRWGRKVVDNASQGEGVRLLPREKSEVQNLLPDTITEEEKERIYGILGQAVCRPAGIQ
DEDITLQITESEDNEEDDMVDVIWRQLISSCPWLSELDESATEGVIKVWRKVVDRIFSLY
KLSCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKHAGELR
QYLEHGLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVGT
ISLSSESQASGNKFSTAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNEDQA
MMQDCYSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQL
EDEVKRVQNNNTLRKEEKIAIMREKHTALMKPIVFALEHVRSITAAPAETPHEKWFQDNY
GDAIENALEKLKTPLNPAKPGSSWIPFKEIMLSLQQRAQKRASYILRLEEISPWLAAMTN
TEIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDE
RIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQR
EAALQAQKAQDSYQTPQNPGIVPRPSELYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVL
EELMEATPPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLID
MTTGEVVHIDYNVCFEKGKSLRVPEKVPFRMTQNIETALGVTGVEGVFRLSCEQVLHIMR
RGRETLLTLLEAFVYDPLVDWTAGGEAGFAGAVYGGGGQQAESKQSKREMEREITRSLFS
SRVAEIKVNWFKNRDEMLVVLPKLDGSLDEYLSLQEQLTDVEKLQGKLLEEIEFLEGAEG
VDHPSHTLQHRYSEHTQLQTQQRAVQEAIQVKLNEFEQWITHYQAAFNNLEATQLASLLQ
EISTQMDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLHHY
ATVALQYPKAIFQKHRIEQWKTWMEELICNTTVERCQELYRKYEMQYAPQPPPTVCQFIT
ATEMTLQRYAADINSRLIRQVERLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSL
ASVIISALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTCLVQLLKQ
CHLVPQDLDIPNPMEASETVHLANGVYTSLQELNSNFRQIIFPEALRCLMKGEYTLESML
HELDGLIEQTTDGVPLQTLVESLQAYLRNAAMGLEEETHAHYIDVARLLHAQYGELIQPR
NGSVDETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKIDIIREARSTQ
VNFFDDDNHRQVLEEIFFLKRLQTIKEFFRLCGTFSKTLSGSSSLEDQNTVNGPVQIVNV
KTLFRNSCFSEDQMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAK
DFGAESKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLASSYDTAWKKHDLVRRLETSIS
SCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKKLHTLSQIETSIA
TVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKESQRASQVTFLCS
NIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELELRLLQRVDTGLEH
PIGSSEWLLSAHKQLTQDMSTQRAIQTEKEQQIETVCETIQNLVDNIKTVLTGHNRQLGD
VKHLLKAMAKDEEAALADGEDVPYENSVRQFLGEYKSWQDNIQTVLFTLVQAMGQVRSQE
HVEMLQEITPTLKELKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAVRS
NTGQKTQPDVMSQNARKLIQKNLATSADTPPSTVPGTGKSVACSPKKAVRDPKTGKAVQE
RNSYAVSVWKRVKAKLEGRDVDPNRRMSVAEQVDYVIKEATNLDNLAQLYEGWTAWV
|
| External Links |
|---|
| GenBank ID Protein
| 16506130 |
| UniProtKB/Swiss-Prot ID
| Q96Q15 |
| UniProtKB/Swiss-Prot Entry Name
| SMG1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB061371 |
| GeneCard ID
| SMG1 |
| GenAtlas ID
| SMG1 |
| HGNC ID
| HGNC:30045 |
| References |
|---|
| General References
| Not Available |