| Identification |
|---|
| HMDB Protein ID
| CDBP04060 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphoinositide 3-kinase regulatory subunit 4 |
| Description
| Not Available |
| Synonyms
|
- PI3-kinase p150 subunit
- PI3-kinase regulatory subunit 4
- Phosphoinositide 3-kinase adaptor protein
|
| Gene Name
| PIK3R4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| kinase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| protein kinase activity |
| protein serine/threonine kinase activity |
| Process |
| cellular metabolic process |
| protein amino acid phosphorylation |
| phosphorylation |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Phosphatidylinositol Phosphate Metabolism |    |  | | Joubert syndrome |    | Not Available | | Inositol Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q22.1 |
| SNPs
| PIK3R4 |
| Gene Sequence
|
>4077 bp
ATGGGAAATCAGCTTGCTGGCATTGCTCCCTCCCAGATCCTTTCTGTAGAGAGTTATTTT
TCAGATATTCATGACTTTGAATATGATAAAAGCCTGGGGAGTACTCGGTTTTTTAAAGTT
GCTCGAGCCAAGCACCGAGAAGGCCTGGTCGTTGTGAAGGTTTTTGCAATTCAGGATCCC
ACATTGCCTTTAACCAGCTATAAACAAGAGCTGGAGGAACTGAAAATCAGGCTTAATTCT
GCACAGAATTGTCTACCTTTCCAGAAAGCATCAGAAAAAGCATCTGAGAAAGCAGCTATG
CTCTTTAGGCAGTATGTGCGAGACAATCTCTATGATCGCATCAGTACCCGTCCATTCTTG
AATAACATTGAGAAGCGCTGGATTGCTTTCCAGATCCTGACAGCTGTGGACCAAGCACAC
AAATCTGGAGTTCGTCATGGGGACATCAAGACTGAGAATGTGATGGTCACCAGTTGGAAT
TGGGTTCTTCTAACTGATTTTGCCAGTTTTAAGCCCACTTATCTTCCAGAAGACAACCCG
GCAGATTTCAATTATTTCTTTGACACATCACGGAGGAGAACTTGCTATATTGCTCCTGAA
CGTTTTGTTGATGGTGGGATGTTTGCCACTGAGTTAGAATATATGAGAGATCCTTCAACT
CCGCTTGTAGACTTAAATAGCAATCAGAGAACAAGAGGAGAGTTGAAGAGAGCAATGGAC
ATCTTTTCAGCAGGTTGTGTGATAGCTGAGCTTTTTACAGAAGGTGTACCATTATTTGAT
CTCTCTCAACTTTTGGCTTATAGAAATGGACATTTTTTCCCTGAACAAGTGCTAAATAAA
ATTGAAGATCACAGTATCAGAGAATTGGTAACTCAGATGATTCACCGTGAGCCAGATAAA
CGTTTAGAGGCAGAAGATTACTTAAAACAGCAGCGTGGCAATGCCTTTCCTGAAATATTT
TACACTTTTCTTCAGCCCTACATGGCCCAGTTTGCCAAGGAAACGTTTCTTTCTGCAGAT
GAGCGTATTCTGGTTATACGGAAGGATTTGGGCAACATTATTCACAATCTCTGTGGACAT
GATCTGCCAGAAAAAGCCGAAGGAGAGCCTAAGGAAAATGGGCTGGTTATCTTGGTATCT
GTTATAACATCCTGCCTACAGACCCTTAAATACTGTGATTCCAAACTAGCTGCTTTGGAA
CTGATTCTTCATTTGGCTCCAAGATTAAGTGTTGAAATCCTTTTGGATCGTATTACTCCA
TATCTTTTGCATTTCAGCAATGACTCTGTTCCTAGGGTGAGGGCTGAAGCCTTGAGGACG
TTGACCAAAGTTCTTGCTCTCGTCAAAGAGGTTCCTCGTAATGATATCAATATTTATCCG
GAATACATTCTGCCAGGCATAGCCCACTTAGCCCAAGATGATGCTACTATCGTTAGACTA
GCCTATGCTGAAAACATAGCTCTGCTGGCAGAAACAGCTCTGAGATTCCTGGAATTAGTA
CAGTTAAAAAATCTTAATATGGAAAATGACCCCAATAATGAAGAAATAGATGAGGTTACA
CATCCAAATGGAAATTATGACACAGAGCTCCAAGCCTTACATGAAATGGTCCAGCAGAAA
GTTGTTACTTTGCTAAGTGACCCTGAAAATATTGTAAAACAAACCTTGATGGAAAATGGA
ATAACACGGCTGTGTGTATTCTTTGGACGTCAGAAAGCCAACGATGTTTTGTTGTCCCAC
ATGATTACTTTCCTAAATGATAAGAATGATTGGCATCTACGTGGAGCATTTTTTGATAGT
ATAGTTGGTGTTGCTGCCTATGTTGGCTGGCAAAGCTCCTCAATTCTCAAGCCTCTGCTG
CAACAAGGTCTTAGTGATGCTGAGGAATTTGTCATTGTGAAAGCTCTTTATGCCCTTACT
TGTATGTGCCAGTTAGGACTGCTACAAAAACCCCATGTTTACGAATTTGCCAGTGATATT
GCCCCCTTCCTGTGTCATCCCAATTTATGGATACGTTATGGTGCCGTGGGATTTATCACA
GTGGTAGCTCGTCAAATAAGTACAGCTGATGTCTACTGTAAACTGATGCCTTATCTTGAC
CCATATATTACCCAACCAATAATACAGATTGAAAGAAAACTTGTTCTGCTCAGTGTTTTA
AAGGAACCAGTAAGTCGTTCTATATTTGATTATGCTTTGAGGTCTAAAGATATTACTAGC
TTGTTCAGACATCTTCACATGCGTCAGAAGAAACGAAATGGTTCTCTTCCCGACTGCCCT
CCGCCAGAGGATCCTGCCATAGCACAGCTTCTGAAGAAGTTGCTCTCACAGGGAATGACA
GAGGAAGAGGAAGACAAACTTCTGGCACTGAAAGACTTCATGATGAAATCTAATAAAGCA
AAGGCCAATATAGTGGACCAGAGCCATCTTCATGATAGTAGTCAGAAAGGTGTAATTGAC
TTGGCAGCTTTAGGCATAACTGGGAGACAAGTTGATCTTGTTAAAACCAAACAAGAACCA
GATGACAAACGGGCCAGAAAACATGTAAAACAAGACTCAAATGTAAATGAAGAATGGAAA
AGCATGTTTGGGTCACTGGACCCACCAAACATGCCACAGGCCCTACCTAAAGGGAGTGAT
CAGGAGGTGATTCAGACTGGGAAACCTCCTCGTTCCGAGTCCTCTGCTGGCATTTGTGTC
CCTTTGTCAACTTCTTCACAGGTTCCAGAAGTGACAACTGTCCAAAATAAAAAACCAGTA
ATACCGGTTTTAAGTAGTACAATCTTACCATCCACCTATCAGATTCGAATTACAACTTGT
AAAACTGAACTTCAGCAACTCATCCAGCAAAAGCGGGAGCAGTGCAATGCTGAGAGAATA
GCTAAGCAGATGATGGAAAATGCTGAATGGGAGAGTAAACCACCACCACCTGGATGGCGT
CCTAAAGGGCTGTTAGTTGCCCATCTTCATGAGCATAAATCTGCTGTGAATCGAATTAGA
GTCTCTGATGAACACTCACTTTTTGCAACATGTTCAAATGATGGCACAGTGAAAATCTGG
AACAGTCAAAAGATGGAGGGGAAGACCACCACTACCAGATCTATTCTTACATACAGCCGA
ATTGGAGGACGAGTCAAGACGCTCACATTCTGCCAAGGCTCCCACTATTTAGCCATAGCA
TCTGATAATGGTGCTGTCCAGCTTCTTGGAATTGAGGCTTCTAAGCTGCCCAAGTCTCCT
AAAATCCATCCTCTACAAAGCAGAATTCTAGATCAGAAGGAGGACGGTTGTGTTGTGGAT
ATGCATCACTTCAACTCTGGAGCACAGTCTGTTCTTGCCTATGCCACTGTGAATGGCTCT
CTGGTTGGCTGGGACCTTAGGTCTTCAAGCAATGCGTGGACTTTAAAGCATGATTTAAAG
TCGGGCCTCATCACTTCCTTTGCTGTGGACATCCACCAATGCTGGCTCTGCATTGGTACA
AGCAGTGGTACCATGGCTTGTTGGGACATGAGGTTCCAGTTGCCAATTTCAAGTCACTGT
CATCCTTCCAGGGCTCGAATCAGACGCCTCTCAATGCACCCTCTGTATCAGTCCTGGGTG
ATTGCAGCTGTTCAGGGCAACAACGAAGTGTCCATGTGGGACATGGAGACTGGTGACAGA
AGATTTACTCTCTGGGCCAGCAGTGCACCACCACTTTCTGAATTACAGCCTTCTCCTCAT
AGCGTCCATGGTATCTACTGTAGTCCTGCAGATGGAAATCCTATCCTACTAACAGCTGGC
TCAGATATGAAAATAAGGTTTTGGGACTTGGCTTACCCAGAAAGGTCCTATGTTGTTGCA
GGAAGTACTAGTTCCCCATCTGTGTCCTACTACAGGAAAATAATTGAAGGCACTGAAGTT
GTCCAGGAAATTCAGAATAAGCAGAAAGTAGGACCAAGTGATGACACCCCTCGAAGGGGC
CCAGAGTCCCTGCCCGTGGGACATCATGACATCATCACTGATGTCGCCACATTCCAGACC
ACACAGGGCTTCATCGTAACTGCTTCTAGAGATGGGATTGTGAAGGTGTGGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 1358 |
| Molecular Weight
| 153102.1 |
| Theoretical pI
| 7.17 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phosphoinositide 3-kinase regulatory subunit 4
MGNQLAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDP
TLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFL
NNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNP
ADFNYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMD
IFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDK
RLEAEDYLKQQRGNAFPEIFYTFLQPYMAQFAKETFLSADERILVIRKDLGNIIHNLCGH
DLPEKAEGEPKENGLVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITP
YLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDATIVRL
AYAENIALLAETALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQK
VVTLLSDPENIVKQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDS
IVGVAAYVGWQSSSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDI
APFLCHPNLWIRYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVL
KEPVSRSIFDYALRSKDITSLFRHLHMRQKKRNGSLPDCPPPEDPAIAQLLKKLLSQGMT
EEEEDKLLALKDFMMKSNKAKANIVDQSHLHDSSQKGVIDLAALGITGRQVDLVKTKQEP
DDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQALPKGSDQEVIQTGKPPRSESSAGICV
PLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQIRITTCKTELQQLIQQKREQCNAERI
AKQMMENAEWESKPPPPGWRPKGLLVAHLHEHKSAVNRIRVSDEHSLFATCSNDGTVKIW
NSQKMEGKTTTTRSILTYSRIGGRVKTLTFCQGSHYLAIASDNGAVQLLGIEASKLPKSP
KIHPLQSRILDQKEDGCVVDMHHFNSGAQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLK
SGLITSFAVDIHQCWLCIGTSSGTMACWDMRFQLPISSHCHPSRARIRRLSMHPLYQSWV
IAAVQGNNEVSMWDMETGDRRFTLWASSAPPLSELQPSPHSVHGIYCSPADGNPILLTAG
SDMKIRFWDLAYPERSYVVAGSTSSPSVSYYRKIIEGTEVVQEIQNKQKVGPSDDTPRRG
PESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
|
| External Links |
|---|
| GenBank ID Protein
| 83759166 |
| UniProtKB/Swiss-Prot ID
| Q99570 |
| UniProtKB/Swiss-Prot Entry Name
| PI3R4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC110318 |
| GeneCard ID
| PIK3R4 |
| GenAtlas ID
| PIK3R4 |
| HGNC ID
| HGNC:8982 |
| References |
|---|
| General References
| Not Available |