| Identification |
|---|
| HMDB Protein ID
| CDBP04059 |
| Secondary Accession Numbers
| Not Available |
| Name
| PH domain leucine-rich repeat-containing protein phosphatase 1 |
| Description
| Not Available |
| Synonyms
|
- PH domain-containing family E member 1
- Pleckstrin homology domain-containing family E member 1
- Suprachiasmatic nucleus circadian oscillatory protein
- hSCOP
|
| Gene Name
| PHLPP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. May act as a negative regulator of K-Ras signaling in membrane rafts.
|
| GO Classification
|
| Biological Process |
| apoptotic process |
| phosphatidylinositol-mediated signaling |
| entrainment of circadian clock |
| circadian rhythm |
| epidermal growth factor receptor signaling pathway |
| fibroblast growth factor receptor signaling pathway |
| nerve growth factor receptor signaling pathway |
| Cellular Component |
| cytosol |
| nucleus |
| membrane |
| Function |
| binding |
| catalytic activity |
| protein binding |
| Molecular Function |
| phospholipid binding |
| protein serine/threonine phosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | PI3K-Akt signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| 18q21.33 |
| SNPs
| PHLPP1 |
| Gene Sequence
|
>5154 bp
ATGGAGCCCGCCGCCGCGGCCACGGTACAGCGACTCCCCGAGCTCGGCAGGGAGGACCGA
GCTTCGGCTCCGGCGGCCGCCGCTGCGGCAGCAGCAGCAGCAGCGGCGGCCGCGGCGGCT
CTGGCGGCGGCGGCCGGGGGCGGCCGGAGTCCGGAGCCCGCGCTGACCCCGGCGGCCCCG
AGCGGCGGGAACGGCAGCGGCAGCGGGGCGCGGGAAGAGGCCCCAGGCGAGGCGCCGCCG
GGGCCGCTGCCGGGCAGAGCGGGGGGTGCCGGGCGCAGGAGGCGGCGCGGGGCGCCCCAG
CCCATTGCCGGCGGGGCTGCCCCCGTACCCGGGGCCGGCGGCGGCGCCAACTCCCTCCTG
CTGAGGAGAGGGCGGCTGAAGAGGAATCTGTCCGCGGCCGCCGCGGCCGCCTCCTCGTCG
TCGTCGTCCTCGGCCGCTGCTGCCTCGCACTCCCCCGGCGCTGCCGGCCTCCCCGCCTCC
TGCTCGGCCTCGGCGTCGCTGTGCACCCGGAGCCTGGACAGGAAGACGCTGCTTCTGAAG
CACCGGCAGACGCTGCAGCTGCAGCCGTCGGACCGGGACTGGGTGAGGCACCAGCTCCAG
CGCGGCTGCGTGCACGTCTTCGACCGCCACATGGCCTCGACCTACCTGCGCCCGGTGCTC
TGCACACTGGACACCACGGCCGGCGAGGTGGCCGCCCGCCTGCTGCAGCTGGGCCACAAA
GGCGGCGGCGTGGTGAAGGTGCTGGGCCAGGGGCCCGGAGCCGCCGCCGCCCGGGAGCCC
GCTGAACCGCCCCCCGAGGCCGGCCCCCGGCTGGCGCCCCCGGAGCCGCGGGACTCGGAG
GTACCGCCCGCGAGGAGCGCGCCGGGTGCCTTCGGGGGGCCTCCGCGCGCGCCCCCCGCC
GACCTACCCCTGCCCGTCGGCGGCCCGGGCGGGTGGTCGCGCCGCGCCAGCCCAGCGCCC
TCGGACTCCAGCCCCGGCGAGCCGTTCGTTGGGGGCCCTGTCTCTTCGCCCCGCGCCCCA
CGGCCTGTGGTCTCCGACACCGAGAGCTTCAGTCTGAGTCCCAGCGCCGAGAGCGTGTCT
GACCGGTTGGACCCCTACAGCAGCGGCGGCGGCTCCTCGTCGTCGTCGGAAGAGCTCGAG
GCCGACGCAGCCTCGGCCCCGACGGGGGTCCCGGGCCAGCCCCGCCGTCCCGGCCACCCC
GCGCAGCCCCTCCCGCTTCCCCAGACGGCTTCCTCGCCTCAGCCGCAGCAGAAAGCCCCG
AGGGCCATTGACAGCCCGGGCGGGGCCGTCCGCGAGGGGTCGTGCGAGGAGAAGGCAGCG
GCAGCCGTGGCCCCGGGAGGCCTCCAGTCTACCCCCGGGAGGAGCGGGGTGACCGCGGAG
AAGGCGCCTCCGCCGCCCCCGCCGCCCACCCTGTACGTGCAGCTCCACGGAGAGACCACC
CGGCGCTTGGAGGCGGAGGAGAAGCCATTGCAGATCCAAAATGACTACCTCTTCCAACTG
GGATTTGGGGAGCTGTGGAGGGTGCAGGAGGAAGGCATGGACTCGGAGATTGGCTGCCTC
ATCCGCTTCTATGCAGGAAAACCTCACAGCACGGGTAGCTCTGAACGGATTCAGCTCTCA
GGAATGTATAATGTCCGTAAAGGCAAGATGCAGTTGCCAGTGAACCGATGGACAAGACGC
CAAGTCATCCTATGTGGGACCTGCCTGATAGTATCATCTGTGAAAGACAGCTTGACCGGA
AAGATGCATGTTCTGCCACTAATTGGTGGAAAAGTAGAAGAAGTGAAAAAGCACCAACAC
TGTTTAGCATTTAGCTCCTCTGGACCCCAAAGCCAGACTTACTACATTTGCTTTGATACT
TTCACAGAATACTTAAGGTGGCTGCGACAAGTCTCCAAGGTTGCATCCCAGCGCATTAGC
TCAGTGGACCTCTCGTGTTGTAGCCTGGAACATCTGCCTGCCAACCTCTTCTACAGCCAA
GACCTCACTCATCTCAATTTAAAACAAAACTTCCTAAGGCAGAACCCTAGCCTTCCAGCT
GCCAGGGGGCTTAATGAACTGCAAAGGTTCACCAAGTTGAAGAGTCTTAACCTTTCCAAT
AATCATTTAGGGGACTTCCCACTGGCAGTCTGCAGTATTCCAACCCTGGCAGAGCTGAAC
GTGTCCTGCAATGCCCTGCGATCAGTCCCGGCAGCCGTTGGAGTGATGCACAACTTACAG
ACATTTTTGTTGGATGGAAACTTTCTCCAATCCCTTCCTGCTGAGTTGGAGAACATGAAG
CAGCTTAGTTATCTGGGTCTTTCTTTCAATGAATTTACTGACATTCCCGAAGTATTGGAG
AAATTGACTGCTGTGGATAAACTTTGTATGTCTGGAAACTGTGTGGAGACCCTTAGGCTA
CAGGCTTTAAGAAAAATGCCTCACATTAAACATGTGGATCTAAGGTTGAACGTAATTAGG
AAGCTGATAGCAGATGAAGTGGACTTTCTACAGCATGTTACTCAGCTTGACCTACGAGAC
AATAAGCTTGGTGATCTAGATGCTATGATTTTCAACAACATTGAAGTTTTACACTGTGAA
AGGAATCAACTGGTCACATTAGACATCTGTGGCTATTTCCTAAAAGCGCTCTATGCCTCT
TCTAATGAACTTGTTCAACTTGATGTTTACCCAGTTCCAAATTATCTGTCCTACATGGAT
GTTTCAAGGAACCGCTTAGAAAATGTGCCTGAGTGGGTATGTGAAAGCCGAAAGCTAGAA
GTTTTGGATATTGGCCATAATCAAATATGTGAACTTCCTGCCCGCTTATTTTGTAATAGC
AGTCTCCGGAAACTACTGGCAGGACACAACCAGTTGGCAAGGCTGCCTGAAAGGCTAGAA
AGAACCTCGGTGGAGGTCTTGGATGTGCAACACAACCAGCTCCTTGAGCTCCCACCTAAC
CTTCTGATGAAGGCTGACAGCCTGAGATTCCTGAACGCCTCTGCGAACAAACTGGAAAGC
CTTCCTCCAGCCACGCTTTCCGAAGAGACAAACAGTATCTTACAAGAGTTGTATTTGACA
AATAACAGCCTCACAGACAAATGTGTGCCCTTGTTAACGGGACACCCCCATTTGAAGATC
CTTCACATGGCCTATAACCGACTTCAGAGTTTTCCAGCAAGTAAAATGGCGAAACTGGAG
GAACTTGAAGAAATTGATCTCAGTGGGAATAAGCTGAAAGCCATCCCAACAACGATCATG
AATTGCAGGCGCATGCACACCGTGATTGCTCACTCCAACTGCATCGAGGTCTTTCCCGAA
GTTATGCAGCTCCCAGAGATCAAGTGTGTGGACCTGAGCTGTAATGAGCTAAGTGAAGTC
ACATTACCAGAAAACCTGCCTCCCAAACTGCAGGAGCTAGACCTGACTGGAAACCCGCGC
CTTGTCCTTGATCACAAAACCCTGGAACTACTGAATAATATCCGCTGTTTCAAGATTGAT
CAGCCTTCTACAGGAGACGCTTCCGGAGCCCCAGCTGTATGGAGTCATGGTTACACTGAA
GCTTCGGGGGTAAAAAACAAGTTGTGTGTCGCAGCCCTGTCGGTGAATAACTTCTGTGAC
AACCGCGAAGCCCTGTATGGTGTGTTTGACGGAGACCGGAATGTGGAGGTGCCCTACCTT
CTCCAGTGCACTATGAGTGACATTTTGGCTGAAGAGCTGCAAAAAACAAAAAACGAAGAA
GAATACATGGTCAATACATTCATTGTCATGCAAAGGAAACTTGGAACTGCTGGGCAGAAG
CTTGGTGGTGCCGCTGTCCTTTGTCATATCAAGCATGACCCTGTGGATCCAGGAGGATCC
TTCACCTTGACCTCTGCTAATGTGGGCAAGTGCCAAACAGTTCTCTGTCGAAATGGAAAG
CCGCTGCCTCTGTCCAGATCTTACATCATGAGCTGTGAAGAAGAGCTGAAGAGGATTAAA
CAGCACAAGGCCATTATCACTGAGGATGGCAAGGTGAACGGAGTGACTGAGTCCACGCGC
ATCCTGGGCTACACCTTCCTCCATCCCAGTGTGGTGCCTCGCCCCCACGTGCAGTCCGTG
CTCCTGACTCCCCAGGATGAGTTCTTCATCCTAGGCAGTAAGGGGTTGTGGGACAGCCTG
TCCGTCGAGGAGGCCGTGGAAGCCGTGCGCAACGTGCCCGATGCCCTGGCTGCTGCCAAG
AAGCTGTGTACCCTGGCCCAGAGCTACGGCTGCCACGACAGCATCAGCGCTGTGGTGGTG
CAGCTCAGTGTCACTGAGGACAGCTTCTGCTGCTGCGAGCTCAGCGCCGGTGGGGCTGTG
CCACCACCCAGTCCTGGCATCTTTCCTCCCTCAGTGAACATGGTGATCAAGGATCGGCCC
TCAGATGGGCTGGGCGTGCCGTCCTCCAGCAGCGGCATGGCTTCCGAGATTAGCAGTGAG
CTCTCCACTTCTGAGATGAGCAGCGAGGTGGGGTCAACAGCCTCCGATGAGCCCCCGCCC
GGAGCCCTAAGCGAGAACAGCCCTGCCTACCCCAGTGAGCAGCGCTGCATGCTCCACCCC
ATCTGTCTGTCCAACTCCTTCCAGCGCCAGCTATCCAGCGCCACGTTCTCTAGCGCCTTC
TCCGACAACGGCCTTGACAGTGACGATGAGGAGCCCATCGAGGGCGTCTTCACCAACGGC
AGCCGGGTGGAGGTGGAGGTGGACATCCACTGCAGCCGGGCCAAGGAGAAGGAGAAACAG
CAGCACCTGCTTCAGGTGCCAGCAGAGGCCAGTGATGAGGGCATTGTCATCAGCGCCAAC
GAGGATGAGCCAGGTCTGCCCAGGAAGGCAGACTTCTCTGCCGTTGGGACCATTGGGCGC
CGGAGGGCCAATGGCTCTGTTGCGCCCCAGGAAAGGAGCCACAATGTGATAGAGGTGGCT
ACAGACGCACCTCTTCGAAAGCCTGGAGGCTATTTTGCTGCCCCGGCTCAGCCGGATCCT
GATGATCAGTTTATCATACCCCCGGAGCTGGAAGAGGAGGTCAAAGAAATCATGAAGCAT
CACCAGGAGCAACAGCAGCAGCAGCAGCCGCCACCACCCCCTCAGCTCCAGCCGCAGCTG
CCGCGGCACTACCAGCTGGACCAGCTGCCAGATTATTACGACACGCCACTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1717 |
| Molecular Weight
| 184670.48 |
| Theoretical pI
| 6.281 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>PH domain leucine-rich repeat-containing protein phosphatase 1
MEPAAAATVQRLPELGREDRASAPAAAAAAAAAAAAAAAALAAAAGGGRSPEPALTPAAP
SGGNGSGSGAREEAPGEAPPGPLPGRAGGAGRRRRRGAPQPIAGGAAPVPGAGGGANSLL
LRRGRLKRNLSAAAAAASSSSSSSAAAASHSPGAAGLPASCSASASLCTRSLDRKTLLLK
HRQTLQLQPSDRDWVRHQLQRGCVHVFDRHMASTYLRPVLCTLDTTAGEVAARLLQLGHK
GGGVVKVLGQGPGAAAAREPAEPPPEAGPRLAPPEPRDSEVPPARSAPGAFGGPPRAPPA
DLPLPVGGPGGWSRRASPAPSDSSPGEPFVGGPVSSPRAPRPVVSDTESFSLSPSAESVS
DRLDPYSSGGGSSSSSEELEADAASAPTGVPGQPRRPGHPAQPLPLPQTASSPQPQQKAP
RAIDSPGGAVREGSCEEKAAAAVAPGGLQSTPGRSGVTAEKAPPPPPPPTLYVQLHGETT
RRLEAEEKPLQIQNDYLFQLGFGELWRVQEEGMDSEIGCLIRFYAGKPHSTGSSERIQLS
GMYNVRKGKMQLPVNRWTRRQVILCGTCLIVSSVKDSLTGKMHVLPLIGGKVEEVKKHQH
CLAFSSSGPQSQTYYICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYSQ
DLTHLNLKQNFLRQNPSLPAARGLNELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELN
VSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNEFTDIPEVLE
KLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLRLNVIRKLIADEVDFLQHVTQLDLRD
NKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQLDVYPVPNYLSYMD
VSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLAGHNQLARLPERLE
RTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYLT
NNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIM
NCRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPKLQELDLTGNPR
LVLDHKTLELLNNIRCFKIDQPSTGDASGAPAVWSHGYTEASGVKNKLCVAALSVNNFCD
NREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNTFIVMQRKLGTAGQK
LGGAAVLCHIKHDPVDPGGSFTLTSANVGKCQTVLCRNGKPLPLSRSYIMSCEEELKRIK
QHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFILGSKGLWDSL
SVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAV
PPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP
GALSENSPAYPSEQRCMLHPICLSNSFQRQLSSATFSSAFSDNGLDSDDEEPIEGVFTNG
SRVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANEDEPGLPRKADFSAVGTIGR
RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFIIPPELEEEVKEIMKH
HQEQQQQQQPPPPPQLQPQLPRHYQLDQLPDYYDTPL
|
| External Links |
|---|
| GenBank ID Protein
| 291219891 |
| UniProtKB/Swiss-Prot ID
| O60346 |
| UniProtKB/Swiss-Prot Entry Name
| PHLP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_194449.2 |
| GeneCard ID
| PHLPP1 |
| GenAtlas ID
| PHLPP1 |
| HGNC ID
| HGNC:20610 |
| References |
|---|
| General References
| Not Available |