| Identification |
|---|
| HMDB Protein ID
| CDBP04058 |
| Secondary Accession Numbers
| Not Available |
| Name
| PH domain leucine-rich repeat-containing protein phosphatase 2 |
| Description
| Not Available |
| Synonyms
|
- PH domain leucine-rich repeat-containing protein phosphatase-like
- PHLPP-like
|
| Gene Name
| PHLPP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
|
| GO Classification
|
| Biological Process |
| metabolic process |
| Cellular Component |
| cytoplasm |
| nucleus |
| membrane |
| Function |
| binding |
| catalytic activity |
| protein binding |
| Molecular Function |
| phosphoprotein phosphatase activity |
| metal ion binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | PI3K-Akt signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q22.2 |
| SNPs
| PHLPP2 |
| Gene Sequence
|
>3972 bp
ATGAAACGCAATGGGAGCAGAAATTGTTTGAATAGGAGAAGTAGGTTTGGTTCTCGAGAA
AGAGACTGGCTAAGAGAAGATGTAAAGAGAGGCTGTGTTTACCTTTATGGAGCAGACACT
ACCACTGCCACTACAACCACCACCACCTCCTCTTCCTCTTCCTCCTCCTCCTCTTCCTCT
GACTTACATCTCGTCCTTTGCACTGTAGAGACACCAGCATCAGAAATATGTGCTGGAGAG
GGAAGAGAAAGTCTTTATTTACAGCTTCATGGAGACCTGGTCAGGAGACTGGAACCTACT
GAACGACCTCTTCAGATCGTTTATGATTACTTATCCAGGCTGGGATTTGATGATCCTGTG
CGCATACAGGAGGAGGCTACAAATCCTGACCTCGGCTGTATGATTCGATTTTATGGTGAA
AAACCATGCCACATGGATCGTTTGGATCGAATCCTATTGTCTGGCATCTATAATGTACGC
AAGGGAAAGACCCAGCTGCATAAGTGGGCTGAGCGCCTAGTTGTCCTCTGTGGTACCTGC
CTTATCGTTTCCTCAGTGAAGGATTGTCAAACTGGAAAGATGCACATTTTGCCTCTGGTT
GGTGGAAAGATAGAAGAAGTGAAGCGACGGCAATACTCCCTTGCTTTCAGCTCAGCAGGA
GCCCAAGCTCAGACCTATCATGTCAGCTTCGAGACTTTGGCCGAGTACCAGCGATGGCAA
CGGCAAGCATCCAAGGTGGTGTCCCAGCGAATCAGTACCGTGGATCTCTCGTGTTACAGC
CTCGAGGAGGTTCCTGAGCATCTCTTCTATAGTCAAGATATTACCTACCTCAACTTGCGA
CACAACTTCATGCAGTTAGAAAGACCCGGAGGCCTCGATACACTCTACAAATTTTCTCAA
CTGAAGGGCCTGAACTTGTCCCATAATAAACTTGGGTTGTTTCCTATATTGTTATGCGAG
ATCTCTACCCTGACTGAGCTCAACCTTTCCTGTAATGGATTTCATGACCTACCAAGTCAA
ATTGGCAATCTGCTAAATCTTCAAACCCTCTGTCTTGATGGCAACTTTCTGACTACTTTA
CCTGAAGAATTGGGAAATCTACAACAGCTTTCCTCCTTGGGAATTTCCTTCAACAACTTT
AGTCAAATTCCTGAGGTTTATGAGAAACTCACTATGTTAGATAGAGTGGTTATGGCAGGA
AATTGCCTGGAAGTCCTGAACTTAGGGGTGCTGAATAGGATGAACCATATCAAGCATGTG
GATTTAAGGATGAACCATTTGAAAACCATGGTTATTGAAAATCTGGAGGGAAATAAACAC
ATCACCCACGTGGATCTGCGGGACAACCGACTGACTGACTTGGATCTTAGCTCCTTATGC
AGCTTGGAACAGCTGCACTGTGGGCGGAATCAGCTGAGGGAGCTAACACTCAGTGGCTTT
TCCCTTCGGACCCTCTATGCCAGTTCCAACAGGCTGACAGCAGTGAACGTCTATCCAGTA
CCCAGCCTGCTCACTTTCTTGGATCTCTCCCGAAACCTGCTAGAGTGTGTCCCTGACTGG
GCCTGTGAAGCAAAGAAGATAGAAGTATTAGATGTGAGCTATAATCTTCTCACAGAGGTT
CCCGTGAGAATTCTGAGTAGCTTGAGTCTTAGAAAACTGATGCTGGGACACAATCATGTG
CAAAACCTTCCAACACTGGTAGAGCACATCCCCCTCGAGGTGCTGGATCTTCAGCATAAT
GCACTCACGAGGCTGCCAGACACCCTCTTCTCCAAGGCCTTAAATCTCAGATACTTGAAT
GCATCTGCAAATAGTCTGGAGTCTTTACCATCCGCCTGCACTGGAGAGGAGAGTTTGAGT
ATGCTGCAGCTGCTTTATCTGACCAACAATCTCCTGACGGATCAGTGCATACCTGTCCTG
GTAGGGCACCTGCACCTGCGAATCTTGCACCTTGCAAACAATCAGTTACAGACCTTTCCT
GCAAGCAAACTAAATAAATTGGAGCAATTGGAGGAACTGAACCTAAGTGGCAACAAGCTT
AAAACCATTCCCACAACCATAGCAAACTGTAAAAGGCTGCACACCCTTGTTGCACACTCC
AACAACATCAGCATTTTCCCAGAAATACTGCAGTTGCCTCAGATCCAGTTTGTAGACCTA
AGTTGCAACGACTTGACAGAAATCCTGATTCCAGAGGCTTTGCCTGCTACATTACAAGAC
CTTGACCTGACTGGAAATACAAATCTGGTTCTGGAACACAAGACACTGGACATATTTAGC
CATATCACAACCCTGAAAATTGATCAGAAACCTTTGCCAACCACAGATTCTACAGTTACG
TCAACCTTCTGGAGCCATGGACTGGCTGAGATGGCAGGGCAGAGAAATAAGCTGTGTGTC
TCAGCACTTGCTATGGATAGCTTTGCAGAGGGGGTGGGAGCTGTGTATGGCATGTTTGAT
GGAGACCGAAATGAGGAGCTCCCGCGCCTGCTGCAGTGTACGATGGCAGATGTGCTTTTA
GAAGAGGTACAGCAGTCAACTAATGACACAGTTTTCATGGCTAACACCTTCTTGGTATCT
CACAGGAAATTAGGAATGGCTGGCCAGAAGTTGGGCTCCTCCGCTCTCCTGTGCTACATC
CGCCCTGACACTGCCGATCCAGCAAGTAGCTTTAGCTTGACTGTAGCCAATGTTGGCACG
TGCCAAGCAGTCCTGTGCCGAGGTGGGAAGCCAGTGCCCCTCTCTAAAGTCTTCAGCCTG
GAGCAGGACCCAGAGGAGGCTCAAAGGGTGAAGGACCAAAAAGCCATCATCACAGAGGAC
AACAAAGTGAATGGGGTAACCTGCTGTACCCGGATGCTGGGCTGTACATACCTCTACCCT
TGGATCCTCCCCAAGCCCCACATATCTTCCACTCCGCTGACCATTCAAGATGAGTTGCTG
ATTCTGGGAAACAAAGCATTGTGGGAACACTTGTCCTACACAGAAGCTGTCAATGCTGTA
CGTCACGTACAAGACCCATTAGCAGCTGCTAAGAAGCTGTGCACATTAGCGCAGAGCTAT
GGCTGTCAGGACAATGTAGGGGCGATGGTAGTTTATTTGAATATTGGTGAGGAAGGCTGC
ACTTGTGAAATGAATGGGCTCACCCTCCCAGGTCCTGTGGGATTTGCTTCAACCACCACT
ATCAAGGATGCCCCTAAGCCAGCCACTCCATCCTCTAGCAGTGGGATTGCCTCTGAGTTC
AGCAGTGAGATGTCCACCTCAGAGGTGAGCAGTGAAGTGGGGTCCACTGCTTCTGATGAG
CATAATGCTGGGGGCCTGGACACTGCCTTGCTTCCGAGGCCAGAGCGGCGCTGCAGCCTC
CACCCAACACCCACCTCTGGGCTGTTTCAGCGCCAGCCTTCTTCTGCTACCTTCTCCAGT
AACCAGTCTGACAACGGCCTGGACAGTGATGATGACCAGCCCGTTGAGGGGGTCATAACC
AATGGCAGCAAGGTAGAGGTGGAAGTAGACATCCACTGCTGCAGGGGGAGGGATCTGGAG
AACTCACCCCCTCTCATAGAGAGTTCTCCTACCCTGTGTTCTGAGGAACATGCTAGAGGG
TCGTGTTTTGGGATCCGAAGACAGAACAGTGTGAATAGTGGCATGCTCCTGCCAATGAGC
AAGGACAGGATGGAGTTACAGAAGTCTCCCTCCACCTCCTGCCTCTATGGGAAGAAACTC
TCCAATGGCTCTATTGTGCCCCTAGAGGACAGCCTGAACCTCATTGAAGTGGCCACAGAA
GTGCCCAAGAGGAAAACTGGCTATTTTGCTGCCCCCACTCAGATGGAACCAGAGGACCAG
TTTGTTGTGCCTCATGACCTGGAAGAAGAAGTGAAGGAACAAATGAAACAGCACCAGGAC
AGCCGGCTCGAGCCTGAGCCCCATGAAGAGGATCGGACCGAGCCCCCGGAGGAGTTCGAC
ACAGCACTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1323 |
| Molecular Weight
| 146749.61 |
| Theoretical pI
| 5.707 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>PH domain leucine-rich repeat-containing protein phosphatase 2
MKRNGSRNCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTTTSSSSSSSSSSS
DLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPTERPLQIVYDYLSRLGFDDPV
RIQEEATNPDLGCMIRFYGEKPCHMDRLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTC
LIVSSVKDCQTGKMHILPLVGGKIEEVKRRQYSLAFSSAGAQAQTYHVSFETLAEYQRWQ
RQASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQ
LKGLNLSHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTL
PEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHV
DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGF
SLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEV
PVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLN
ASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFP
ASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDL
SCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDIFSHITTLKIDQKPLPTTDSTVT
STFWSHGLAEMAGQRNKLCVSALAMDSFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLL
EEVQQSTNDTVFMANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPASSFSLTVANVGT
CQAVLCRGGKPVPLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYP
WILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSY
GCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEF
SSEMSTSEVSSEVGSTASDEHNAGGLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSS
NQSDNGLDSDDDQPVEGVITNGSKVEVEVDIHCCRGRDLENSPPLIESSPTLCSEEHARG
SCFGIRRQNSVNSGMLLPMSKDRMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATE
VPKRKTGYFAAPTQMEPEDQFVVPHDLEEEVKEQMKQHQDSRLEPEPHEEDRTEPPEEFD
TAL
|
| External Links |
|---|
| GenBank ID Protein
| 65301141 |
| UniProtKB/Swiss-Prot ID
| Q6ZVD8 |
| UniProtKB/Swiss-Prot Entry Name
| PHLP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015020.2 |
| GeneCard ID
| PHLPP2 |
| GenAtlas ID
| PHLPP2 |
| HGNC ID
| HGNC:29149 |
| References |
|---|
| General References
| Not Available |