| Identification |
|---|
| HMDB Protein ID
| CDBP04024 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sulfiredoxin-1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| SRXN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase |
| GO Classification
|
| Function |
| oxidoreductase activity |
| sulfiredoxin activity |
| binding |
| catalytic activity |
| oxidoreductase activity, acting on a sulfur group of donors |
| nucleic acid binding |
| dna binding |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 20p13 |
| SNPs
| SRXN1 |
| Gene Sequence
|
>414 bp
ATGGGGCTGCGTGCAGGAGGAACGCTGGGCAGGGCCGGCGCGGGTCGGGGGGCGCCCGAG
GGGCCCGGGCCGAGCGGCGGCGCGCAGGGCGGCAGCATCCACTCGGGCCGCATCGCCGCG
GTGCACAACGTGCCGCTGAGCGTGCTCATCCGGCCGCTGCCGTCCGTGTTGGACCCCGCC
AAGGTGCAGAGCCTCGTGGACACGATCCGGGAGGACCCAGACAGCGTGCCCCCCATCGAT
GTCCTCTGGATCAAAGGGGCCCAGGGAGGTGACTACTTCTACTCCTTTGGGGGCTGCCAC
CGCTACGCGGCCTACCAGCAACTGCAGCGAGAGACCATCCCCGCCAAGCTTGTCCAGTCC
ACTCTCTCAGACCTAAGGGTGTACCTGGGAGCATCCACACCAGACTTGCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 137 |
| Molecular Weight
| 14259.0 |
| Theoretical pI
| 8.46 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Sulfiredoxin-1
MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPA
KVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQS
TLSDLRVYLGASTPDLQ
|
| External Links |
|---|
| GenBank ID Protein
| 189065267 |
| UniProtKB/Swiss-Prot ID
| Q9BYN0 |
| UniProtKB/Swiss-Prot Entry Name
| SRXN1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK312054 |
| GeneCard ID
| SRXN1 |
| GenAtlas ID
| SRXN1 |
| HGNC ID
| HGNC:16132 |
| References |
|---|
| General References
| Not Available |